Bronchoscope-guided microwave ablation of early-stage lung tumors

支气管镜引导下早期肺部肿瘤微波消融

基本信息

批准号：
10312004
负责人：
Punit Prakash
金额：
$ 20.09万
依托单位：
KANSAS STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-01-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10312004
关键词：
Ablation Address Animal Model Animals British Columbia Bronchoscopes Bronchoscopy Clinical Clinical Research Computer Models Coupled Data Deposition Development Devices Ensure Environment Evaluation Feedback Goals Growth Heating Human Incineration Industrialization Industry Interstitial Lung Diseases Kansas Kidney Liver Lung Lung Neoplasms Lung diseases Machine Learning Malignant neoplasm of lung Medical Modality Monitor Nodule Non-Small-Cell Lung Carcinoma Nonionizing Radiation Operative Surgical Procedures Organ Outcome Patients Pattern Physicians Pilot Projects Pneumothorax Positioning Attribute Procedures Pulmonary Emphysema Radiation therapy Research Research Support Risk Safety Survival Rate System Techniques Technology Thermal Ablation Therapy Time Tissues Toxic effect Translating Translational Research Translations Treatment Efficacy Treatment outcome Universities Unresectable Work animal data base computerized cost cost effective cost effective treatment design effective therapy efficacious treatment efficacy outcomes electric impedance experience experimental study first-in-human flexibility image guided improved in vivo innovation lung preservation microwave ablation microwave electromagnetic radiation minimal risk minimally invasive novel optimal treatments pre-clinical pulmonary function real time monitoring safety and feasibility simulation tool treatment planning tumor tumor ablation virtual

项目摘要

PROJECT SUMMARY In this Industry-Academic partnership R01 research plan, we propose the development, optimization, and pilot first-in-human evaluation of a bronchoscope-guided microwave ablation (MWA) system for rapid and conformal thermal ablation of early stage pulmonary tumors. Minimally-invasive, image- guided MWA is a cost-effective treatment for thermal destruction of unresectable tumors in the liver, lung, kidney, and other organs. Current MWA technology for pulmonary tumors is limited to a percutaneous approach, which precludes treatment of central tumors and has a high associated risk of pneumothorax. Furthermore, limited intra-procedural feedback and lack of guidance and treatment planning tools places a substantial burden on the physician to precisely position applicators and ensure adequate ablation of the target, while limiting damage to non-targets. Virtual bronchoscopy and navigation, pioneered by Broncus Medical (industrial partner), affords accurate, minimally-invasive access to early-stage pulmonary tumors, with minimal risk of pneumothorax, compared to a percutaneous approach. The team at Kansas State University (academic partner) will develop optimized flexible microwave applicators for delivering localized thermal ablation to pulmonary tumors via a bronchoscopic approach. The proposed MWA devices include antennas with directional control of microwave power deposition for precise ablation of small targets, and will be extensively evaluated with computational models and experimentally, on the benchtop, and in an in vivo animal model. Transient changes in antenna impedance matching will be exploited as a feedback parameter for assessing ablation progress. A machine-learning based treatment planning and guidance platform will be developed and integrated with Broncus’ Archimedes planning and virtual bronchoscopy platform to guide the selection of optimal treatment parameters. The integrated system will be translated for first-in- human studies to evaluate the feasibility and safety of bronchoscopically delivering MWA for targeting pulmonary tumors (subaward with University of British Columbia, through Broncus Medical). The central hypothesis of this research is that a bronchoscopic MWA system integrating: (1) applicators with directional control of ablation profiles; (2) impedance-based intra-procedural feedback; and (3) bronchoscopic guidance and treatment planning tools, will afford the safe and effective treatment of localized early-stage pulmonary tumors. The proposed research will lead to the development of an integrated system for bronchoscopic ablation of pulmonary tumors, and its pilot feasibility assessment in human patients. If successful, this work will considerably expand the range of patients with lung tumors that can be treated with a cost-effective, minimally-invasive approach.

项目摘要在这个行业 - 学术伙伴关系R01研究计划中，我们提出了开发，优化，以及对支气管镜指导的微波消融（MWA）系统的先验性第一名评估早期肺肿瘤的快速和共形热消融。微不足道的图像 - 指导MWA是一种具有成本效益的治疗方法肺，肾脏和其他器官。当前用于肺部肿瘤的MWA技术仅限于经皮方法，它排除了中枢肿瘤的治疗，并且具有很高的相关风险气胸。此外，限制了术中反馈以及缺乏指导和治疗规划工具对物理至精确的位置施用者进行了大量燃烧，并确保适当的目标消融，同时限制对非目标的损害。虚拟支气管镜检查和由Broncus Medical（工业合作伙伴）开创的导航提供准确的，微不足道的与A相比经皮方法。堪萨斯州立大学（学术合作伙伴）的团队将发展优化的柔性微波涂抹器，用于向肺部肿瘤输送局部热消融通过支气管镜方法。提出的MWA设备包括具有方向控制的天线微波功率沉积以精确消融小目标，并将通过广泛评估计算模型和实验，在台式上以及体内动物模型中。瞬态天线阻抗匹配的变化将作为评估的反馈参数探讨消融进展。基于机器学习的治疗计划和指导平台将是与野马的Archimedes计划和虚拟支气管镜平台开发并集成到指导最佳治疗参数的选择。集成系统将被翻译成首次人类研究以评估支气管计提供MWA的可行性和安全性肺部肿瘤（与不列颠哥伦比亚大学的亚武力，通过野马医学）。这项研究的中心假设是支气管镜MWA系统集成：（1）消融曲线的定向控制；（2）基于阻抗内部反馈反馈；（3）支气管镜指导和治疗计划工具，将提供安全有效的治疗局部的早期肺部肿瘤。拟议的研究将导致发展用于肺肿瘤的支气管镜消融的综合系统及其试验可行性评估在人类患者中。如果成功，这项工作将考虑到肺的患者范围可以通过具有成本效益的微创方法治疗的肿瘤。