Culturally relevant contributors to cognitive and MRI changes in older Latinos

老年拉丁裔认知和 MRI 变化的文化相关因素

• 批准号: 10316218
• 负责人: Melissa Lamar
• 金额: $ 74.18万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10316218
• 关键词: Acculturation; Address; Adopted; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Behavior; Blood Vessels; Brain; Cognition; Cognitive; Cohort Studies; Crime; Data; Demyelinations; Diabetes Mellitus; Family; Future; Goals; Health; High Prevalence; Hypertension; Impaired cognition; Individual; Informatics; Infrastructure; Intervention Studies; Investigation; Iron; Knowledge; Language; Latino; Latino Population; Link; Literature; Magnetic Resonance Imaging; Measures; Minority Groups; Modification; Motor; Neighborhoods; Nerve Degeneration; Outcome; Pattern; Population; Prevalence; Process; Public Health; Reaction Time; Research; Risk Factors; Sampling; Smoking; Social Environment; Societies; Study of Latinos; Time; Work; aging brain; brain magnetic resonance imaging; cardiovascular disorder risk; cognitive change; cohort; data acquisition; dementia risk; digital; experience; follow-up; health disparity; indexing; member; multimodal neuroimaging; multimodality; neuroimaging; perceived discrimination; preference; stressor; theories

PROJECT SUMMARY/ABSTRACT Latinos are one of the fastest growing minority populations in the US, and they are 1.5 times as likely to develop Alzheimer’s dementia as older non-Latino Whites. Culturally relevant factors such as acculturation, the process by which Latinos adapt to the US and potentially adopt its values and practices, may contribute to health disparities in brain aging and Alzheimer’s dementia in Latinos. While levels of acculturation have been linked to a number of health outcomes in Latinos, less work has been done in cognition and brain aging. Newer theories of acculturation suggest it is not a static, linear process but a dynamic exchange between Latinos and other members of society that emerges from and is reinforced by broader socioenvironmental determinants vital to a process now called ‘acculturation in context’ (AIC). Thus, in addition to traditional acculturation factors (e.g., language preference and/or years in the US), individual-level (e.g., perceived discrimination, family and/or cultural stressors) and neighborhood-level (e.g., crime rates) socioenvironmental determinants need to be integrated into research in older Latinos. We will incorporate advances in geospatial informatics to quantify neighborhood-level determinants of AIC, longitudinal multi-modal neuroimaging, and the digital capture of behavior in a well-characterized cohort of Latinos 60 years and older for the most comprehensive study of AIC as it relates to brain aging in Latinos. By 2030, the Latino population 65 and older will increase by ~225% compared to a 65% increase in non-Latino Whites; rates for Alzheimer’s dementias will also disproportionately increase for older Latinos. This R01, with its focus on AIC and brain aging in Latinos, may provide a more comprehensive understanding of the reasons for this disproportionate increase. To achieve the overall goal of the study – to investigate the relationship of AIC to changes in cognition and brain MRI indices in older Latinos and determine whether these factors affect the well-documented relationships between other risk factors and changes in cognition or brain MRI indices – we will conduct a comprehensive assessment of the AIC framework including the geocoding of neighborhood factors, repeat multi-modal MRI, and the digital capture of behavior in 350 older Latinos. We will leverage the infrastructure of two cohort studies at the Rush Alzheimer’s Disease Center to incorporate ongoing longitudinal data acquisition of cognition and other risk factors into this R01. When combined, this information will allow us to examine the relationship of AIC to change in cognition (Aim 1) and brain MRI indices (Aim 2) in older Latinos, and determine if levels of AIC modify the relationship of cardiovascular disease risk factor profiles to changes in cognition or brain MRI indices in this same population (Aim 3). Given that rates of Alzheimer’s dementia are disproportionately increasing for Latinos in the US, understanding modifiable contributors to this health disparity that may be specific to this population is critical.

项目摘要/摘要 拉丁美洲人是美国增长最快的少数族裔之一，它们的可能性是1.5倍 将阿尔茨海默氏症的痴呆作为较老的非拉丁裔白人发展。具有文化相关因素，例如适应， 拉丁美洲人适应美国并可能采用其价值和实践的过程，可能有助于 拉丁美洲人的大脑衰老和阿尔茨海默氏症的痴呆症的健康差异。虽然培养水平已经 与拉丁美洲人的许多健康结果有关，在认知和大脑衰老方面做了更少的工作。较新 培养理论表明，它不是一个静态的线性过程，而是拉丁美洲和拉丁裔之间的动态交流 更广泛的社会环境决定者从并加强了社会的其他成员 对于现在称为“上下文中的适应性”的过程至关重要（AIC）。除了传统的培养因素外 （例如，在美国的语言偏好和/或年份），个人级别（例如，感知的歧视，家庭 和/或文化压力源）和社区级别（例如犯罪率）社会环境决定者需要 纳入较旧的拉丁裔研究中。我们将纳入地理空间信息的进步来量化 AIC，纵向多模式神经影像学的邻里级别的决定者以及数字捕获 最全面的AIC研究，在60岁及以上的拉丁美洲人群体中的行为中 与拉丁美洲人的大脑衰老有关。到2030年，拉丁裔人口65岁及以上的人口将增加约225％ 与非拉丁裔白人增加65％相比；阿尔茨海默氏痴呆症的率也将不成比例 较旧的拉丁美洲人增加。这款R01侧重于拉丁美洲人的AIC和大脑衰老，可能会提供更多 对这种不成比例增加的原因的全面理解。 为了实现研究的总体目标 - 调查AIC与认知变化的关系 较旧拉丁裔的大脑MRI指数，并确定这些因素是否影响有据可查 其他风险因素与认知或大脑MRI指数的变化之间的关系 - 我们将进行 对AIC框架的全面评估，包括邻里因素的地理编码，重复 多模式MRI以及350个较旧的拉丁裔行为的数字捕获。我们将利用 在阿尔茨海默氏病中心的两项队列研究中，纳入了正在进行的纵向数据获取 R01的认知和其他风险因素。合并后，此信息将使我们能够检查 AIC与认知（AIM 1）和大脑MRI指数（AIM 2）的关系在较旧的拉丁裔和 确定AIC的水平是否修改了心血管疾病危险因素概况与变化的关系 在同一人群中的认知或大脑MRI指数（AIM 3）。鉴于阿尔茨海默氏痴呆症的比率是 美国拉丁美洲人的不成比例增加，了解对这种健康的可修改贡献者 可能特定于该人群的差异至关重要。