Linking sensory uncertainty with motivation and memory

将感觉不确定性与动机和记忆联系起来

基本信息

批准号：
10315376
负责人：
Michael Cohanpour
金额：
$ 4.6万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10315376
关键词：
Address Affect Animals Anterior Anxiety Area Attention Automobile Driving Behavior Behavioral Brain Categories Decision Making Delayed Memory Dorsal Environment Food Functional Magnetic Resonance Imaging Future Goals Hippocampus (Brain)Hour Human Image Incentives Influentials Knowledge Laboratories Learning Link Literature Measures Mediating Mediation Memory Methods Midbrain structure Modeling Mood Disorders Motivation Neurons Participant Pathologic Pathway interactions Population Prevalence Proxy Reporting Rewards Semantics Sensory Short-Term Memory Signal Transduction Source Stimulus Temporal Lobe Testing Therapeutic Intervention Time Training Uncertainty Visual Visual system structure Work career cingulate cortex clinically relevant cognitive function cost design information processing innovation insight intrinsic motivation motivated behavior neuromechanism novel response sensory input tool visual information visual memory

项目摘要

Abstract: Processing information that reduces uncertainty is a key role of the brain. Emerging evidence shows that, in addition to using information that is given to them, animals actively seek to obtain information about future rewards or semantic (trivia) questions. Information demand (ID) is robust even when it is non-instrumental (cannot be exploited to increase reward gains). Moreover, non-instrumental ID activates the reward-sensitive dopaminergic midbrain and enhances memory, suggesting that uncertainty, independently of reward gains, is a source of motivation for decision making and cognitive function. However, little is known about the neural mechanisms mediating these effects of uncertainty. I will address this question by designing a new task that measures perceptual ID and allows me to examine how signals of sensory uncertainty relate to those of motivation and memory. I identified visual images – “texforms” – that reliably activate human ventral temporal cortex (VTC) and can be distorted in a controlled fashion to parametrically manipulate the uncertainty about animate/ inanimate stimulus categories. Second, I will use a generative model to decode trial-by-trial sensory uncertainty from stimulus-evoked multi-voxel activity in the VTC. Finally, I show preliminary evidence that perceptual ID (the desire to reveal the identity of an ambiguous image) is related to behavioral reports of confidence (a proxy of uncertainty). In Aim 1, I will examine the hypothesis that sensory uncertainty in VTC relates to midbrain activity either directly or mediated by univariate responses to confidence (such as those in the dorsal anterior cingulate cortex). In Aim 2, I will examine the hypothesis that VTC uncertainty modulates the hippocampus and generates ID-related memory enhancements. Furthermore, I will explore the possibility that distinct network interactions mediate the effect of ID on immediate and delayed memory. Together, the findings will bring significant new insights into the pathways through which multivariate and univariate signals of uncertainty motivate actions that reduce uncertainty and affect memory. In addition, the results will expand our understanding of pathways that produce maladaptive effects of uncertainty in disorders of mood and anxiety.

抽象的：处理减少不确定性的信息是大脑的关键作用。除了使用给他们的信息外，动物积极寻求获取有关未来的信息奖励或语义（Trivia）问题（ID）也很健壮（不能利用增加奖励GARS）。多巴胺能中脑并增强记忆，表明不确定性独立于奖励收益，是一个决策和认知功能的动机来源。介导不确定性影响的机制。衡量感知ID，并允许我检查感官不确定性与动机和记忆。皮质（VTC），可以以受控的方式扭曲，以操纵有关的不确定性动画/无生命的刺激类别。 VTC中刺激诱发的多素活性活性的不确定性。感知ID（揭示模棱两可图像的身份的愿望）与行为报告有关置信度（AIM 1的不确定性）。与中间脑活动直接或通过单变量对信心的反应介导的有关）在AIM 2中，我将检查VTC不确定性调节您的假设海马并生成与ID相关的内存增强。不同的网络交互介导ID对立即和延迟内存的影响将为jltivarialials off的途径带来重要的新见解不确定性激发了减少不确定性并影响记忆的动作。了解在情绪和焦虑症的情绪障碍中产生不确定性不确定性的途径。