NYU Collaborative Center In Children's Environmental Health Research and Translation

纽约大学儿童环境健康研究与翻译合作中心

• 批准号: 10307276
• 负责人: CHAU TRINH-SHEVRIN
• 金额: $ 84.75万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-17 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10307276
• 关键词: Adoption; Asian Americans; Behavior; Behavior Therapy; Biological Markers; Centers for Disease Control and Prevention (U.S.); Chemicals; Child; Child Health; Clinical Sciences; Communities; Community Health; Consumption; Development; Diet; Disease; Environment; Environmental Hazards; Environmental Health; Evidence based intervention; Expenditure; Exposure to; Flame Retardants; Funding; Guidelines; Health; Home; Hospitals; Household; Human; Infrastructure; Institutes; Intervention; Investigation; Knowledge; Laboratories; Lead; Low income; Mentors; Methods; Minority; Modeling; Modification; Multiple Birth Offspring; Muslim religion; National Institute of Environmental Health Sciences; National Institute on Minority Health and Health Disparities; Organophosphates; Outcome; Pesticides; Pilot Projects; Policies; Poly-fluoroalkyl substances; Population; Population Heterogeneity; Prevention Research; Procedures; Public Health; Public Health Practice; Research; Research Personnel; Resources; System; Testing; Time; Training; Translational Research; Translations; Work; bisphenol A; brief prevention intervention; built environment; cohort; design; dietary; disability; disorder prevention; dissemination research; economic evaluation; evidence base; hazard; health communication; health economics; health equity; health literacy; implementation science; improved; innovation; obesity in children; obesogenic; phthalates; preventive intervention; ranpirnase; repository; success; therapy design; tool; uptake

PROJECT SUMMARY (OVERALL) The NIEHS/EPA Children's Environmental Health (CEH) and Disease Prevention Centers have rapidly unraveled the contribution of chemical hazards to disease and disability. Substantial progress has been made to develop interventions that reduce exposure, yet uptake and adoption of interventions remains limited at the community and systems levels, in public health practice, and nationally. Most interventions have not been adapted for diverse populations or settings, nor are they typically designed to scale, especially for low-income, minority and low health literacy populations with disproportionate exposure. And few studies have rigorously quantified the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. To achieve higher population-wide impact, CEH researchers require expertise on dissemination research, implementation science methods and public health practice frameworks to cross the translational bridge and achieve success in scaling evidence-based interventions across communities for maximum impact. The objective of our proposed NYU Collaborative Center in Children's Environmental Health Research and Translation (CEHRT) is to serve as a Resource for the CEH community by: (1) developing meaningful prevention and intervention strategies that have promise to scale, (2) adapting these strategies for diverse populations or settings, to achieve higher population-wide impact, and (3) rigorously quantifying the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. NYU CEHRT unites the expertise of four existing translational Centers to meet these urgent challenges and protect children from environmental hazards. The cross-cutting themes of NYU CEHRT include: intervention testing, implementation science, health equity and economic evaluation. NYU CEHRT is also home to two Environmental Influences on Child Health Outcomes (ECHO) cohort centers (UH3OD023305 and UH3OD023332), and therefore extremely well-poised to integrate new knowledge about emerging exposures likely to emerge from ECHO and the broader CEH community. It leverages the expertise of a world-class analytical chemist, Kurunthachalam Kannan, whose NIEHS Human Health Exposure Analysis Resource laboratory (U2CES026452) can support and stimulate innovative pilot projects to rigorously examine changes in biomarkers of exposure resulting from modifications in diet, behavior and household factors. NYU CEHRT will create a robust, mentored training environment that stimulates and supports innovation by early stage investigators in promising time-sensitive, applied or interventional CEH research. It will advance translational CEH research through innovative pilot projects to test and adapt promising or evidence-based interventions in diverse settings, and utilize implementation science and dissemination research frameworks to improve uptake and adoption of CEH research findings.

项目摘要（总体） NIEHS/EPA儿童环境健康（CEH）和疾病预防中心迅速 解散了化学危害对疾病和残疾的贡献。已经取得了重大进展 为了制定减少暴露量的干预措施，但采用和采用干预措施仍在 社区和系统水平，公共卫生实践和全国。大多数干预措施不是 适用于不同的人群或设置，也不是通常设计的，尤其是针对低收入的人群 少数民族和低健康素养人群，暴露不成比例。很少有研究严格 量化了制造变化，政策干预或饮食和其他行为的影响 旨在减少暴露的干预措施。为了获得更高人口的影响，CEH研究人员 需要有关传播研究，实施科学方法和公共卫生实践的专业知识 越过翻译桥并取得成功的框架 在整个社区中，最大程度地影响。我们拟议的纽约大学合作中心的目的 儿童环境健康研究与翻译（CEHRT）将作为CEH的资源 社区作者：（1）制定有望扩大规模的有意义的预防和干预策略，（2） 为各种人群或环境调整这些策略，以实现较高的人口影响，（3） 严格量化制造业变化，政策干预或饮食和其他的影响 旨在减少暴露的行为干预措施。 NYU CEHRT团结了四个现有的专业知识 转化中心应对这些紧急挑战，并保护儿童免受环境危害。这 NYU CEHRT的跨切割主题包括：干预测试，实施科学，卫生公平和 经济评估。 NYU CEHRT也有两个环境影响对儿童健康成果的影响 （Echo）队列中心（UH3OD023305和UH3OD023332），因此非常齐全以集成 关于新兴暴露的新知识可能会从Echo和CEH社区中出现。它 利用世界一流的分析化学家Kurunthachalam Kannan的专业知识，他的Niehs人 健康暴露分析资源实验室（U2CES026452）可以支持和刺激创新的飞行员 严格检查因饮食修改而导致的暴露生物标志物变化的项目 和家庭因素。 NYU CEHRT将创造一个强大的指导的培训环境，以刺激和 支持早期研究人员的创新，以有希望的时间敏感，应用或介入的CEH 研究。它将通过创新的试点项目来进步CEH转化研究，以测试和适应 在各种环境中采取有希望或基于证据的干预措施，并利用实施科学和 分发研究框架以改善CEH研究结果的吸收和采用。