Stroke Trials Network-Regional Coordinating Center University of Pittsburgh (STN-UP)

中风试验网络-匹兹堡大学区域协调中心 (STN-UP)

• 批准号: 10306019
• 负责人: MARCELO ROCHA
• 金额: $ 31.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10306019
• 关键词: Accident and Emergency department; Admission activity; Adopted; Adult; Advisory Committees; Agreement; Area; Cause of Death; Cessation of life; Childhood; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Communities; Community Outreach; Community Physician; Development; Devices; Education; Embolectomy; Enrollment; Ensure; Evaluation; Faculty; Fellowship; Fibrinolytic Agents; Fostering; Funding; Healthcare; Hospitals; Industry; Infrastructure; Institutes; Institution; Institutional Review Boards; Intervention; Leadership; Maryland; Measures; Mechanics; Medical; Medical center; Mission; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neuroprotective Agents; Neurosciences; Patient Recruitments; Patients; Pennsylvania; Pharmaceutical Preparations; Phase; Physicians; Population; Presbyterian Church; Public Health; Recovery; Rehabilitation therapy; Research; Research Personnel; Resources; Stroke; Stroke prevention; Structure; Support Groups; Telemedicine; Telephone; Training; Translational Research; United States; United States National Institutes of Health; Universities; acute stroke; base; career development; clinical care; community clinic; community partnership; cost; data management; design; education research; experience; innovation; lost earning; member; natural hypothermia; nervous system disorder; next generation; novel; outreach program; participant enrollment; participant retention; patient population; pre-clinical; programs; recruit; research study; robotic device; stem cell therapy; stroke clinical trials; stroke risk; stroke survivor; stroke therapy; stroke trials; success; telestroke; therapeutic development; treatment trial

The NIH Stroke Trials Network (StrokeNet) is designed to maximize efficiencies to prioritize, harmonize and streamline the development of high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery. The StrokeNet Regional Coordinating Center (RCC) at the University of Pittsburgh (STN-UP) plans to continue its successful clinical trials structure with improvements based upon our experiences during the initial term of RCC funding. The aims of this proposal to continue as STN-UP are: 1: To continue to build on our strengths as a dynamic, collaborative and sustainable administrative structure to rapidly implement stroke clinical trials and enroll patients across a wide range of adult and pediatric populations. 2: To foster participation of physicians, patients and patient support groups in the STN-UP. 3: To promote career development of young clinician-investigators in the neurosciences STN-UP will be led by the Program Director, Lawrence Wechsler, MD, co-Program Director Tudor Jovin, MD. Strengths of the STN-UP to continue participation as an RCC in the NIH StrokeNet are: 1) Consistent track record of high enrollment in NINDS and industry clinical trials. 2) Over 2000 yearly stroke admissions at three University of Pittsburgh Medical Center (UPMC) core hospitals (UPMC Presbyterian, UPMC Shadyside, and UPMC Mercy) 3) Large telestroke network including 28 hospitals in western Pennsylvania and Maryland with prior experience recruiting patients into stroke trials after telemedicine evaluation. 4) Extensive regional referral network with phone support to hospitals throughout the tri-state area. 5) Participation in StrokeNet, NETT and NeuroNEXT networks, and institutional support for tier-1 federated IRB and master clinical trial agreements. To continue the commitment of training the “next generation” of qualified stroke researchers, the STN-UP will: 1) Maintain our dedicated clinician researcher-oriented fellowship. 2) Recruit trainees to the Advisory Committee on a rotating basis. 3) Provide clinical trials education and experience for residents, fellows and junior faculty.

NIH 中风试验网络 (StrokeNet) 旨在最大限度地提高效率，以优先考虑、协调和 简化专注于中风关键干预措施的高质量、多中心临床试验的开发 预防、治疗和康复。 匹兹堡 (STN-UP) 计划继续其成功的临床试验结构，并根据我们的经验进行改进 RCC 资助初期的经验 本提案继续作为 STN-UP 的目的是： 1：继续发挥我们作为一个充满活力、协作和可持续的管理结构的优势， 快速实施中风临床试验并招募各种成人和儿童患者 人口。 2：促进医生、患者和患者支持团体参与 STN-UP。 3：促进神经科学领域年轻临床医生研究员的职业发展 STN-UP 将由项目总监 Lawrence Wechsler 医学博士、联合项目总监 Tudor Jovin 领导 MD. STN-UP 作为 RCC 继续参与 NIH StrokeNet 的优势包括： 1) NINDS 和行业临床试验的高注册率的一致记录。 2) 匹兹堡大学医学中心 (UPMC) 三个核心中心每年收治超过 2000 例中风患者 医院（UPMC Presbyterian、UPMC Shadyside 和 UPMC Mercy） 3) 大型远程中风网络，包括宾夕法尼亚州西部和马里兰州西部的 28 家医院 在远程医疗评估后招募患者参加中风试验的经验。 4) 广泛的区域转诊网络，为整个三州地区的医院提供电话支持。 5) 参与 StrokeNet、NETT 和 NeuroNEXT 网络，并为一级联合 IRB 提供机构支持 并掌握临床试验协议。 为了继续致力于培训“下一代”合格的卒中研究人员，STN-UP 将： 1) 维持我们专门的以临床医生研究人员为导向的奖学金。 2) 轮流招募实习生加入顾问委员会。 3) 为住院医师、研究员和初级教师提供临床试验教育和经验。