NINDS Stroke Trials Network - Regional Coordinating Center

NINDS 中风试验网络 - 区域协调中心

• 批准号: 10306038
• 负责人: KAMAKSHI LAKSHMINARAYAN
• 金额: $ 30.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10306038
• 关键词: Address; Affect; Age; Award; Caring; Cessation of life; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Development; Disease; Education; Emergency Care; Emergency Medicine; Emergency research; Environment; Fostering; Funding; Goals; Hospitals; Incubators; Individual; Infrastructure; Intervention; Medicine; Minnesota; Mission; Multi-Institutional Clinical Trial; Multicenter Trials; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Patient Recruitments; Patients; Population; Prevention; Public Health; Recovery; Research; Research Personnel; Research Training; Role; Science; Site; Stroke; Stroke prevention; StrokeNet clinical trials; Time; Training; United States National Institutes of Health; Universities; Work; career; career development; design; disability; experience; follow-up; human subject protection; improved; innovation; investigator-initiated trial; medical specialties; member; mortality; nervous system disorder; programs; recruit; research and development; stroke clinical trials; stroke therapy; stroke trials; trend

Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number four cause of none-accidental death in the U.S. It is still the leading cause of major disability, and as the population ages and becomes more diverse, the number of affected individuals is expected to significantly grow. The mission of NINDS is to reduce the burden of neurological disease and stroke. Multicenter clinical trials are key in advancing the science and practice of stroke treatment. National Institutes of Health funded clinical trials have often suffered from long start up time and delays in completing the research. Disease specific research consortiums are part of a national trend to improve these deficiencies by providing a common infrastructure that will facilitate the design, startup, and conduct of multicenter trials, streamlining site selection, research team organization, and human subject protection. It will minimize the need to reorganize the research team for every new trial. Enhanced collaboration will result from such a network, and will function as an incubator for new research and provide a rich environment for research training. The StrokeNET network was created in 2013 to achieve those goals. The University of Minnesota (UMN) and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It has extensive experience in implementing research networks, proven as a current member in StrokeNet, and collaboration with the University of Minnesota hub of SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network, the NINDS/NHLBI emergency medicine research network), as well as the previous experience and relationships built by being part of the two previous funding cycles of the NINDS Neurological Emergency Research Network (NETT). The leaders for this application are experienced in stroke clinical research, managing research networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Within the previous cycle of StrokeNET, our regional center contributed significantly to the network, participating in seven clinical trials with the total number of subjects recruited within the top tier of all RCC’s, a very high rate of patient retention, subject follow-up and document completion. We have actively engaged with 13 hospitals regionally that have recruited patients into network trials. We have brought two proposals for investigator initiated trials and served on several key committees within the network. We have trained four StrokeNet fellows and a team member served on the education committee. Overall, the current stroke program at the University of Minnesota is an excellent candidate to renew its role as an NIH StrokeNet Regional Coordinating Center.

中风是一种常见的神经疾病，是日益严重的公共卫生问题。虽然死亡率是 在下降，它仍然是美国无事故死亡的第四个原因，它仍然是 主要残疾，随着人口的年龄和变化的年龄，受影响的个体的数量是 预计会显着增长。 Ninds的使命是减少神经系统疾病的燃烧和 中风。多中心临床试验是推进中风治疗的科学和实践的关键。国家的 卫生研究院资助的临床试验经常遭受较长的启动时间和延误完成 研究。特定于疾病的研究联盟是改善这些缺陷的国家趋势的一部分 通过提供一个共同的基础设施，该基础设施将促进多中心试验的设计，启动和行为， 简化现场选择，研究团队组织和人类主题保护。它将最小化需求 为每个新试验重组研究团队。加强协作将由这样的网络产生 并将充当新研究的孵化器，并为研究培训提供丰富的环境。这 Strokenet Network于2013年创建以实现这些目标。明尼苏达大学（UMN）及其 中风计划具有独特的资格，可以为区域协调中心服务。它可以访问一组 与该领域相关的学术研究人员，在临床研究的各个领域中具有深度。它有广泛的 实施研究网络的经验，被证明是Strotenet中的现有成员和协作 与明尼苏达大学的警笛枢纽（创新急诊临床试验的策略 网络，Ninds/NHLBI急诊医学研究网络）以及以前的经验和 通过成为Ninds神经紧急事件的前两个资金周期的一部分建立的关系 研究网络（NETT）。该应用的领导者在中风临床研究中经历了 管理研究网络，并且是该主题的专家。所需的各种专业 成功实施试验的协作已经在行政上与协作单位保持一致 超越传统部门。在Strotenet的上一个周期内，我们的区域中心贡献了 网络非常重要，参加了七项临床试验，并参与了受试者总数 在所有RCC的最高层中，患者保留率很高，主题随访和文件 完成。我们已经积极与13家地区的医院互动，这些医院已将患者招募到网络 试验。我们为调查员提出了两项​​提案，并在几个关键委员会中任职 在网络中。我们已经培训了四名街头人群，一名团队成员在教育中任职 委员会。总体而言，明尼苏达大学目前的中风计划是 更新其作为NIH Strokenet区域协调中心的作用。