Validation of a New Stroke Simulation Model for Evaluating Stroke Prevention and Treatment Policies in Type 2 Diabetes Patients

验证用于评估 2 型糖尿病患者中风预防和治疗政策的新中风模拟模型

基本信息

批准号：
10302406
负责人：
Wen Ye
金额：
$ 42.9万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10302406
关键词：
Acute Address Adult Atherosclerosis Brain hemorrhage Caring Clinical Clinical Trials Computer Simulation Computers Cost Analysis Coupled Diabetes Mellitus Diagnosis Direct Costs Disease model Early treatment Economics Effectiveness Evaluation Facilities and Administrative Costs Future Goals Head Health Care Costs Health Care Reform Health Policy Healthcare Intervention Ischemia Ischemic Stroke Knowledge Longitudinal Studies Methods Michigan Modeling Modernization Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Outcome Patients Policies Policy Maker Population Prevalence Prevention Prevention strategy Preventive treatment Primary Prevention Probability Procedures Quality of life Reperfusion Therapy Research Personnel Resources Scientific Advances and Accomplishments Stroke Stroke prevention Structure Time United States Update Validation base comorbidity comparative comparative effectiveness cost cost effective cost effectiveness cost-effectiveness evaluation diabetes control discrete time economic evaluation functional outcomes health management improved model design models and simulation mortality patient population perfusion imaging prevent preventive intervention stroke intervention stroke model stroke patient stroke therapy tool treatment as usual treatment guidelines treatment strategy

项目摘要

Stroke is one of the atherosclerotic cardiovascular diseases that are the leading cause of morbidity and mortality for people with type 2 diabetes (T2DM) and are the largest contributor to the direct and indirect costs of T2MD. Despite improvements in the management of type T2MD, the implementation level of these preventive interventions and treatment for T2MD complications is still suboptimal. Substantial opportunity exists to further improve diabetes control to prevent primary stroke and improve early management to reduce stroke related morbidity, mortality, and cost. We will first validate a new stroke microsimulation model for T2DM that reflects the modern paradigm of diabetes progression, stroke management, and treatment. This model will then be used to evaluate the cost-effectiveness of enhanced levels of implementing seven primary prevention strategies and expanding the current acute ischemic stroke treatment guideline to include selected wake-up stroke patients based on perfusion imaging for stroke in T2DM patients from a national perspective. The results of the evaluation will advance scientific knowledge and will have major implications for health policies for stroke prevention and treatments in type 2 diabetes patients.

中风是动脉粥样硬化性心血管疾病之一，是导致中风的主要原因 2 型糖尿病 (T2DM) 患者的发病率和死亡率，是导致 2 型糖尿病 (T2DM) 的最大因素 T2MD 的直接和间接成本。尽管 T2MD 型的管理有所改善， T2MD 预防干预和治疗的实施水平并发症仍然不理想。进一步改善糖尿病存在大量机会控制以预防原发性中风并改善早期管理以减少中风相关发病率、死亡率和费用。我们将首先验证新的中风微观模拟模型 T2DM 反映了糖尿病进展、中风管理和治疗的现代模式治疗。然后，该模型将用于评估增强水平的成本效益实施七项一级预防策略，扩大当前急性缺血性中风治疗指南将根据灌注情况纳入选定的清醒中风患者从全国角度对 T2DM 患者中风进行影像学检查。评估结果将推进科学知识并对中风卫生政策产生重大影响 2型糖尿病患者的预防和治疗。