India - Factors of CKDu in Uddanam Study (India-FOCUS)

印度 - Uddanam 研究中 CKDu 的因素 (India-FOCUS)

• 批准号: 10300864
• 负责人: Vivekanand Jha
• 金额: $ 56.56万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-25 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10300864
• 关键词: Address; Adult; Affect; Age; Agriculture; Air; Alcohols; Analgesics; Area; Biological Markers; Biopsy; Blood; Chronic Kidney Failure; Clinical; Cohort Studies; Collaborations; Collection; Communities; Country; Coupled; Cross-Sectional Studies; Data; Development; Diabetes Mellitus; Disease; Disease Progression; Dose; Ecology; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Risk Factor; Environmental and Occupational Exposure; Etiology; Evaluation; Family; First Degree Relative; Frequencies; Future; Gender; General Population; Genes; Genetic; Genetic Predisposition to Disease; Glomerular Filtration Rate; Hair; Health system; Healthcare Systems; Heat Stress Disorders; Hematuria; Heterogeneity; Household; Hypertension; India; Individual; Infection; Injury; Injury to Kidney; Intervention; Kidney Diseases; Leadership; Location; Longitudinal Studies; Manuals; Measurement; Measures; Medical; Medical History; Nail plate; Non-Steroidal Anti-Inflammatory Agents; Occupational; Occupations; Participant; Pathway interactions; Patients; Pattern; Perception; Pesticides; Phenotype; Poison; Population; Prevalence; Prevention; Preventive; Proteinuria; Protocols documentation; Public Health; Questionnaires; Recording of previous events; Renal function; Research; Resources; Risk Factors; Sample Size; Sampling; Seasonal Variations; Silicones; Soil; Spouses; Standardization; State Government; Sustainable Development; Testing; Time; Tobacco smoking behavior; Translating; Urine; Visit; Water; Work; age group; agricultural community; case control; clinical examination; cohort; community engagement; design; disability; epidemiology study; experience; follow-up; genetic pedigree; genetic risk factor; kidney biopsy; longitudinal analysis; low socioeconomic status; member; mortality; multidisciplinary; patient subsets; phenotypic data; pollutant; programs; prospective; public health intervention; recruit; sample collection; sex; therapy design

Summary This proposal describes the formation of an experienced multidisciplinary team that is well equipped to complete a comprehensive field epidemiology study of chronic kidney disease of uncertain etiology (CKDu) in the endemic region of Uddanam in South India. This India-FOCUS (India- Factors of CKDu in Uddanam Study) team represents well-established experts in kidney disease, epidemiology environmental science, and project management as well as extensive experience in field work in low resource settings. The India-FOCUS team, who have long standing prior collaborations, will facilitate the successful establishment of a case control longitudinal study that includes 400 participants with CKDu and 800 controls with repeated visits every 9 months. The recruitment strategy for participants with CKDu is designed to allow for careful study of the known familial clustering by the inclusion of at least 100 families with 2 or more affected individuals. Recruited controls will be matched to cases by age, sex, location and occupation. Study participants will undergo careful phenotyping including a detailed medical history, exposure history, standardized validated questionnaires, detailed family pedigree charts, clinical examination. The study will collect biospecimens (blood, urine, hair, nails) from all participants at regular prespecified intervals to measure kidney function, biomarkers of kidney injury, and biomarkers of various environmental exposures (Aim 1a & 1b). A subset of patients will undergo detailed evaluation of heat stress and additional precise measurements of glomerular filtration rate. We will also implement a detailed environmental sample (air, water, soil, silicone bands) collection protocol that will parallel biospecimen collection to facilitate targeted and untargeted analyses of environmental exposures (Aim 2). The results of individual testing and environmental samples will be appropriately returned to the study participants and the community at appropriate time points to help inform the development of effective preventive and interventive measures (Aim 3). Study participants will be followed longitudinally and incident CKDu cases will be identified among the controls. Our study is designed to identify the genetics, exposome and gene-environmental interactions that represent the underlying etiology and risk factors for progression of CKDu. Community engagement will allow the development of sustainable interventions to reduce the burden of CKDu in these communities.

概括 该建议描述了一支经验丰富的多学科团队的形成 完成一项全面的现场流行病学研究，对不确定病因的慢性肾脏疾病（CKDU） 印度南部的乌达南特有地区。这项印度对焦（uddanam研究中CKDU的因素） 团队代表肾脏疾病，流行病学环境科学和项目的完善专家 在低资源设置中的管理以及在现场工作方面的丰富经验。印度对焦团队， 长期以来一直在先前的合作，将促进成功建立案件控制 纵向研究包括400名具有CKDU的参与者和800个对照，每9次反复访问一次 月份。 CKDU参与者的招聘策略旨在仔细研究已知的 通过包含至少100个患有2个或更多受影响的人的家庭聚类。招募控件 将符合年龄，性别，位置和职业的案件。学习参与者会谨慎 表型包括详细的病史，暴露历史，标准化的经过验证的问卷， 详细的家庭血统图，临床检查。这项研究将收集生物测量（血液，尿液，头发， 指甲）来自所有参与者的定期预定时间间隔，以测量肾脏功能，肾脏的生物标志物 伤害和各种环境暴露的生物标志物（AIM 1A和1B）。一部分患者将经历 详细评估热应力和肾小球过滤率的其他精确测量。我们将 还实施详细的环境样本（空气，水，土壤，硅胶带）的收集协议 并行生物循环收集，以促进对环境暴露的有针对性和非目标的分析（AIM 2）。个人测试和环境样本的结果将适当地返回研究 参与者和社区在适当的时间点，以帮助开发有效 预防和干预措施（目标3）。研究参与者将纵向遵循和事件 CKDU病例将在对照之间确定。我们的研究旨在识别遗传学，杂物组 以及代表潜在的病因和风险因素的基因环境相互作用 ckdu。社区参与将允许发展可持续干预措施，以减轻 这些社区中的CKDU。