Neuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural Interfaces

Neuro-CROWN：用于 3D、低噪声神经接口的优化超灵活 CMOS 电极阵列

• 批准号: 10294053
• 负责人: Hui Fang
• 金额: $ 69.09万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-27 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294053
• 关键词: 3-Dimensional; Amplifiers; Animal Model; Animals; BRAIN initiative; Brain; Cerebral cortex; Chronic; Clinical; Code; Communities; Device Designs; Devices; Educational workshop; Electrodes; Electronics; Electrophysiology (science); Evaluation; Feedback; Funding; Future; Generations; Gold; Human; Implant; In Vitro; Intelligence; Measurement; Measures; Methods; Microelectrodes; Modeling; Monitor; Motor; Neurons; Neurosciences; Neurosciences Research; Noise; Performance; Polymers; Population; Prosthesis; Real-Time Systems; Research; Research Personnel; Resolution; Resources; Rodent; Running; Sampling; Semiconductors; Shapes; Signal Transduction; Silicon; Site; Societies; Speech; Surface; System; Techniques; Technology; Testing; Thick; Thinness; Time; Tissues; Training; Transistors; Translating; Update; Wireless Technology; base; biomaterial compatibility; brain machine interface; clinical application; cohort; cost; cost effective; data streams; denoising; density; design; experimental study; extracellular; flexibility; improved; in vivo; instrumentation; irritation; manufacturing process; meetings; metal oxide; millimeter; nervous system disorder; neural circuit; neural implant; neuronal circuitry; neuroprosthesis; neurotransmission; new technology; next generation; nonhuman primate; novel; program dissemination; programs; relating to nervous system; scale up; statistics; system architecture; tissue injury; tool

Project Summary / Abstract The purpose of this project is to optimize circuit and system architectures of active electrode arrays which will provide low-noise, multiplexed acquisition of neural signals from thousands of electrodes. We will reduce noise by exploiting a novel current-sensing circuit approach and new multiplexing strategies, such as Code-Division Multiple Access (CDMA). We will also apply novel system level de-noising approaches using kriging. Finally, we will demonstrate our low noise, active arrays using a unique, ultra-flexible 3D neural interface paradigm: Neuro-CROWN: CMOS-based, ROlling-enabled, loW-noise Neuroelectronics. These electrode arrays include thousands of electrodes that can be used for both recording and stimulation, enabling studies that require recordings from multiple, large cortical regions in rodents and non-human primates (NHP) at cellular scale. The electrode arrays are extremely thin (<25 µm) and flexible, and are made in both non-penetrating and 3D penetrating configurations, of which the latter will be formed from a simple and unique rolling of 2D soft electrode array (ROSE) method. Amplifiers and multiplexers integrated directly into the electrode array, using commercially fabricated silicon transistors, intelligently combine signals inside the array so that recording from up to 4,096 electrodes is possible with fewer than 20 multiplexed external wire connections. The small number of interface wires facilitates long-term experiments in chronically-implanted, freely-behaving animals and eases future wireless integration. The electrode arrays will be manufactured in large quantities (3800 devices / run) using full wafers at X-fab. By leveraging a cost-effective manufacturing process, the raw materials cost of each electrode array will be ~$10, excluding post processing labor which will be supplied by this program. Our dissemination program will make device broadly available to a large cohort of end users. We have previously disseminated early-stage technology to ~10 labs are now scaling up to disseminate that technology to ~100 labs. Based on feedback we received during this dissemination effort, neural interfaces with high SNR and 3-dimensional measurement are critically important to neuroscience research, motivating this project. We will disseminate this new technology to at least 10 labs in this effort, solicited from the neuroscience community at large. We will solicit end user feedback through a workshop at the Society for Neuroscience (SfN) meeting and use this feedback to shape our device designs. This project seeks to enable BRAIN Initiative investigators and the broader neuroscience community to perform very large-scale recordings in animal models. Further, the research enabled by this technology will be able to be rapidly translated to humans in the future, through parallel, separately-funded efforts by our team to bring actively-multiplexed electrode arrays to human use.

项目摘要 /摘要 该项目的目的是优化活动电极阵列的电路和系统架构，该阵列将 提供低噪声，多重地采集来自数千个电子的神经信号。我们将降低噪音 通过利用新颖的电流感应电路方法和新的多路复用策略，例如代码划分 多次访问（CDMA）。我们还将使用Kriging采用新型的系统级别去噪声方法。最后，我们 将使用独特的，超虚拟的3D神经界面范式来证明我们的低噪声，主动阵列： Neuro-Crown：基于CMO的，支持滚动，低噪声神经电子学。这些电极阵列包括 数千个可用于记录和刺激的电子，使得需要研究 来自啮齿动物和非人类素数（NHP）的多个大型皮质区域的记录。这 电极阵列非常薄（<25 µm）且柔性，并在非穿透和3D中制成 穿透配置，后者将是由2D软电极的简单而独特的滚动形成的 阵列（玫瑰）方法。放大器和多路复用器直接集成到电极阵列中，使用商业上 制造的硅晶体管，智能地组合了阵列内的信号，因此录制到4,096 电极是可能的，少于20个多路复用的外线连接。少数接口 电线促进了长期实验的长期植入，自由言论的动物，并简化了未来 无线集成。电极阵列将使用完整的大量（3800个设备 /运行）制造 X-FAB的波浪。通过利用具有成本效益的制造过程，每个电极的原材料成本 阵列将为约10美元，不包括该计划提供的后处理人工。 我们的传播计划将使大量最终用户的设备广泛使用。我们有 以前将早期技术传播到〜10个实验室，现在正在扩大扩展该技术 到〜100个实验室。根据我们在这项传播工作中收到的反馈，神经界面具有高SNR 三维测量对于神经科学研究至关重要，激发了该项目。我们 在这项工作中，将至少将这项新技术传播给至少10个实验室，并从神经科学社区巩固 整个。我们将通过神经科学协会（SFN）会议的研讨会征求最终用户的反馈 并使用此反馈来塑造我们的设备设计。 该项目旨在使大脑倡议调查员和更广泛的神经科学社区能够 在动物模型中执行非常大规模的录音。此外，这项技术的研究将是 将来，它可以通过我们团队的平行，单独资助的努力来迅速转化为人类 将积极的多形电极阵列带入人类使用。