Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 10289498
• 负责人: Hong Zhu
• 金额: $ 18.71万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-20 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10289498
• 关键词: Acute Lymphocytic Leukemia; Address; Adolescent; Bioinformatics; Biological; Biometry; Biostatistics Shared Resource; Child; Clinical; Complex; Comprehensive Cancer Center; Data; Data Analyses; Data Linkages; Data Science; Databases; Development; Doctor of Philosophy; Ensure; Environment; Epidemiology; Ethnic Origin; Future; Genomics; Goals; Grant; Hepatotoxicity; Image; Infrastructure; Latino; Link; Manuscripts; Medical center; Medicine; Molecular Analysis; Neighborhoods; Participant; Pathologic; Patient-Focused Outcomes; Patients; Population Sciences; Preparation; Program Research Project Grants; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Science; Secure; Services; Specimen; Statistical Data Interpretation; Texas; Tissues; Translational Research; Treatment outcome; Treatment-related toxicity; Universities; Visualization; Work; base; central database; clinically significant; college; data management; design; ethnic disparity; improved; improved outcome; member; metabolomics; multilevel analysis; neurotoxicity; population health; preventive intervention; programs; success; treatment disparity

PROJECT SUMMARY – Biostatistics and Data Management Core (Core C) The translational Research Projects proposed in this P20 planning grant integrate many different types of existing and newly generated data, including biological, clinical, demographic, genomic, metabolomic, imaging, and neighborhood variables. The Biostatistics and Data Management Core (Core C) functions as a centralized research design and data science coordination center for all P20 Projects, bringing together expertise and intellectual resources in biostatistics, bioinformatics, geospatial data analysis, and data management for all P20 investigators. Core C will provide the statistical and data science infrastructure needed for development of a future SPORE application upon completion of the P20 planning grant. Core C members will: 1) provide biostatistical and bioinformatics support for rigorous research design and state-of-the-science statistical analysis for all P20 Projects and the Developmental Research Program (DRP); 2) facilitate state-of-the-science geospatial data analysis for all P20 Projects and the DRP; and 3) develop and maintain an integrated database environment for efficient data management, integration, analysis and sharing for all P20 Projects, the DRP and investigator-initiated inquiries. Core C members will work collaboratively with investigators to ensure that the appropriate design is incorporated into all studies from inception, that data are appropriately validated, linked, cleaned and analyzed, and that all results will be interpreted for statistical as well as biological/clinical significance. The Biostatistics and Data Management Core will work with the Administrative Core (Core A) to assist in preparation of reports, data management and other administrative duties; and with the Biospecimen Processing and Storage Core (Core B) for management and analysis of specimen-related data. Fully integrating Core C members into all P20 Projects and other Cores will build workflow efficiencies and support the translational goals of the P20, while enhancing quality and ensuring scientific integrity of participating Projects. Core C will provide sophisticated data management, design, and analysis services in order to facilitate important discoveries about acute lymphoblastic leukemia ethnic disparities and to guide future prevention and intervention strategies.

项目摘要 - 生物统计学和数据管理核心（核心C） P20规划赠款集成中提出的转化研究项目许多不同类型的现有类型 以及新生成的数据，包括生物学，临床，人口统计学，基因组，代谢组，成像和 邻里变量。生物统计学和数据管理核心（核心C）充当集中式 所有P20项目的研究设计和数据科学协调中心，将专业知识和 所有P20 调查人员。核心C将提供开发所需的统计和数据科学基础架构 P20计划赠款完成后未来的孢子申请。核心成员将：1）提供 生物统计学和生物信息学支持严格的研究设计和科学统计学 所有P20项目和发展研究计划（DRP）的分析； 2）促进科学 所有P20项目和DRP的地理空间数据分析； 3）开发和维护一个集成的数据库 用于所有P20项目的有效数据管理，集成，分析和共享的环境，DRP 和研究者发起的查询。核心C成员将与调查人员合作，以确保 合适的设计已纳入所有开始的研究中，该数据得到了适当的验证，链接， 清洁和分析，所有结果都将用于统计以及生物/临床 意义。生物统计学和数据管理核心将与行政核心（核心A）一起使用 协助准备报告，数据管理和其他行政职责；并与生物晶体 处理和存储核心（核心B）用于管理和分析标本相关数据。完全整合 核心C成员进入所有P20项目和其他核心将建立工作流程效率并支持 P20的翻译目标，同时提高质量并确保参与项目的科学完整性。 核心C将提供复杂的数据管理，设计和分析服务，以促进重要 关于急性淋巴细胞白血病种族差异的发现，并指导未来的预防和干预 策略。