Biostatistics and Data Management Core

生物统计和数据管理核心

基本信息

批准号：
10289498
负责人：
Hong Zhu
金额：
$ 18.71万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-20 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10289498
关键词：
Acute Lymphocytic Leukemia Address Adolescent Bioinformatics Biological Biometry Biostatistics Shared Resource Child Clinical Complex Comprehensive Cancer Center Data Data Analyses Data Linkages Data Science Databases Development Doctor of Philosophy Ensure Environment Epidemiology Ethnic Origin Future Genomics Goals Grant Hepatotoxicity Image Infrastructure Latino Link Manuscripts Medical center Medicine Molecular Analysis Neighborhoods Participant Pathologic Patient-Focused Outcomes Patients Population Sciences Preparation Program Research Project Grants Reporting Research Research Design Research Personnel Research Project Grants Resources Science Secure Services Specimen Statistical Data Interpretation Texas Tissues Translational Research Treatment outcome Treatment-related toxicity Universities Visualization Work base central database clinically significant college data management design ethnic disparity improved improved outcome member metabolomics multilevel analysis neurotoxicity population health preventive intervention programs success treatment disparity

项目摘要

PROJECT SUMMARY – Biostatistics and Data Management Core (Core C) The translational Research Projects proposed in this P20 planning grant integrate many different types of existing and newly generated data, including biological, clinical, demographic, genomic, metabolomic, imaging, and neighborhood variables. The Biostatistics and Data Management Core (Core C) functions as a centralized research design and data science coordination center for all P20 Projects, bringing together expertise and intellectual resources in biostatistics, bioinformatics, geospatial data analysis, and data management for all P20 investigators. Core C will provide the statistical and data science infrastructure needed for development of a future SPORE application upon completion of the P20 planning grant. Core C members will: 1) provide biostatistical and bioinformatics support for rigorous research design and state-of-the-science statistical analysis for all P20 Projects and the Developmental Research Program (DRP); 2) facilitate state-of-the-science geospatial data analysis for all P20 Projects and the DRP; and 3) develop and maintain an integrated database environment for efficient data management, integration, analysis and sharing for all P20 Projects, the DRP and investigator-initiated inquiries. Core C members will work collaboratively with investigators to ensure that the appropriate design is incorporated into all studies from inception, that data are appropriately validated, linked, cleaned and analyzed, and that all results will be interpreted for statistical as well as biological/clinical significance. The Biostatistics and Data Management Core will work with the Administrative Core (Core A) to assist in preparation of reports, data management and other administrative duties; and with the Biospecimen Processing and Storage Core (Core B) for management and analysis of specimen-related data. Fully integrating Core C members into all P20 Projects and other Cores will build workflow efficiencies and support the translational goals of the P20, while enhancing quality and ensuring scientific integrity of participating Projects. Core C will provide sophisticated data management, design, and analysis services in order to facilitate important discoveries about acute lymphoblastic leukemia ethnic disparities and to guide future prevention and intervention strategies.

项目摘要 – 生物统计和数据管理核心（核心 C） P20 规划拨款中提出的转化研究项目整合了许多不同类型的现有研究项目以及新生成的数据，包括生物、临床、人口统计、基因组、代谢组、成像和生物统计和数据管理核心（核心 C）充当集中式变量。所有 P20 项目的研究设计和数据科学协调中心，汇集了专业知识和所有 P20 的生物统计学、生物信息学、地理空间数据分析和数据管理方面的智力资源核心 C 将提供开发所需的统计和数据科学基础设施。完成 P20 规划拨款后的未来 SPORE 申请将： 1) 提供。生物统计学和生物信息学支持严格的研究设计和最先进的统计对所有 P20 项目和发展研究计划 (DRP) 的分析；2) 促进最新进展所有 P20 项目和 DRP 的地理空间数据分析；以及 3) 开发和维护综合数据库；为所有 P20 项目、DRP 提供高效数据管理、集成、分析和共享的环境核心 C 成员将与调查人员合作，以确保从一开始就将适当的设计纳入所有研究中，数据经过适当的验证、链接、清洁和分析，所有结果都将被解释为统计以及生物/临床生物统计和数据管理核心将与行政核心（核心 A）合作，以实现其重要性。协助准备报告、数据管理和其他行政职责；以及生物样本；处理和存储核心（核心 B），用于管理和分析样本相关数据。所有 P20 项目和其他核心的核心 C 成员将提高工作流程效率并支持 P20 的转化目标，同时加强参与项目的质量保证和科学完整性。 Core C 将提供复杂的数据管理、设计和分析服务，以促进重要的关于急性淋巴细胞白血病种族差异的发现并指导未来的预防和干预策略。