Speaker-Listener Coupling and Brain Dynamics During Naturalistic Verbal Communication in Alzheimer's Disease

阿尔茨海默病自然语言交流过程中的说话者-听众耦合和大脑动力学

• 批准号: 10285917
• 负责人: Daniel Arthur Abrams
• 金额: $ 39.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285917
• 关键词: Administrative Supplement; Affect; Age; Alzheimer' s Disease; Area; Award; Behavior; Behavioral Medicine; Brain; Caliber; Caregiver Burden; Caregivers; Child; Clinical; Cognitive; Collaborations; Communication; Communication impairment; Comprehension; Coupling; Data; Dementia; Disease; Family member; Functional Magnetic Resonance Imaging; Funding; Goals; Health Promotion; Image; Impairment; Individual; Interpersonal Relations; Language; Lateral; Lead; Link; Measures; Medial; Memory; Modeling; National Institute on Aging; Neurobiology; Neurocognitive; Parents; Patients; Pattern; Personal Satisfaction; Persons; Play; Prefrontal Cortex; Production; Psychology; Quality of life; Research; Resources; Role; Science; Social Functioning; Social Interaction; Social isolation; Speech; System; Time; United States National Institutes of Health; Voice; Work; autistic children; brain dysfunction; comprehension deficit; design; disability; functional disability; improved; language comprehension; language impairment; mortality risk; negative affect; novel; parent grant; parent project; relating to nervous system; response; reward processing; social communication; speech processing

Project Abstract Alzheimer’s disease (AD) is a progressive and severely debilitating disease that negatively affects cognitive and memory function and is linked to increased disability in everyday functioning and risk of mortality. Language function is a crucial area of impairment for AD. Individuals with AD show a wide range of language difficulties which are thought to lead to social isolation in affected individuals, negatively affecting quality of life and well-being for patients, caregivers, and family members. The major goal of our Administrative Supplement is to advance our understanding of the brain mechanisms underlying speech comprehension deficits in patients with AD. To accomplish this goal, we will leverage fMRI task paradigms and neurocognitive models we have recently developed as part of the parent project and ongoing work in collaboration with the Stanford Alzheimer’s Disease Research Center (ADRC). We now propose to extend our original aims with two new Aims designed to build on these findings by examining anticipatory and integrative components of speech processing, with a focus on aberrant organization of the default mode network, in patients with early AD. Critically, to achieve this goal, we will apply the novel experimental and analytic approaches developed by the parent project at Stanford to AD data collected as part of the proposed supplement and resources provided by the Stanford ADRC (P30AG066515) Clinical Core and Imaging Core. Specifically, we will investigate (1) speaker-listener brain coupling during natural speech communication and its relation to narrative comprehension and functional communication abilities in AD and age-matched healthy controls; and (2) the integrity of temporal integration windows underlying naturalistic verbal communication and its relation to narrative comprehension and functional communication abilities in AD and age-matched healthy controls. Our studies will provide critical information regarding the neurobiological origins of communication impairments in AD and will inform therapies and strategies aimed at improving language and social function in dementia.

项目摘要 阿尔茨海默氏病（AD）是一种渐进且严重使人衰弱的疾病，对认知产生负面影响 和记忆功能，与每天功能的残疾增加和死亡风险有关。 语言功能是AD损伤的关键领域。广告中的个人表现出广泛的语言 被认为会导致受影响个人的社会隔离的困难，对生活质量产生负面影响 以及患者，看护人和家庭成员的福祉。我们行政补充的主要目标 是为了促进我们对语音理解潜在的大脑机制的理解定义 AD患者。为了实现这一目标，我们将利用fMRI任务范例和神经认知模型我们 最近与斯坦福大学合作开发了父母项目的一部分和正在进行的工作 阿尔茨海默氏病研究中心（ADRC）。我们现在建议将我们的原始目标扩展到两个新的目标 旨在通过研究语音的预期和综合组成部分来建立这些发现的目的 处理早期AD患者的处理，重点是默认模式网络的异常组织。 至关重要的是，为了实现这一目标，我们将采用由 斯坦福大学的家长项目，以作为拟议补充和资源的一部分收集的广告数据 Stanford ADRC（P30AG066515）临床核心和成像核心。具体而言，我们将调查（1） 在自然语音交流期间，演讲者上列式脑耦合及其与叙事的关系 AD和年龄匹配的健康控制中的理解和功能沟通能力； （2） 临时整合窗口的完整性是自然主义口头交流的基础及其与之的关系 AD和年龄匹配的健康控制中的叙事理解和功能沟通能力。我们的 研究将提供有关沟通障碍神经生物学起源的关键信息 AD并将为旨在改善痴呆症语言和社会功能的疗法和策略提供信息。

项目成果

Atypical pattern separation memory and its association with restricted interests and repetitive behaviors in autistic children.

自闭症儿童的非典型模式分离记忆及其与受限兴趣和重复行为的关联。

• DOI: 10.1177/13623613231223354
• 发表时间: 2024
• 期刊: Autism : the international journal of research and practice
• 作者: Chen,Lang;Liu,Jin;Kang,JuliaBoram;Rosenberg-Lee,Miriam;Abrams,DanielA;Menon,Vinod
• 通讯作者: Menon,Vinod

Epidural labour analgesia and autism spectrum disorder: is the current evidence sufficient to dismiss an association?

• DOI: 10.1016/j.bja.2021.12.017
• 发表时间: 2022-02-24
• 期刊: BRITISH JOURNAL OF ANAESTHESIA
• 影响因子: 9.8
• 作者: Butwick, Alexander J.;Abrams, Daniel A.;Wong, Cynthia A.
• 通讯作者: Wong, Cynthia A.