Speaker-Listener Coupling and Brain Dynamics During Naturalistic Verbal Communication in Alzheimer's Disease

阿尔茨海默病自然语言交流过程中的说话者-听众耦合和大脑动力学

• 批准号: 10285917
• 负责人: Daniel Arthur Abrams
• 金额: $ 39.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285917
• 关键词: Administrative Supplement; Affect; Age; Alzheimer' s Disease; Area; Award; Behavior; Behavioral Medicine; Brain; Caliber; Caregiver Burden; Caregivers; Child; Clinical; Cognitive; Collaborations; Communication; Communication impairment; Comprehension; Coupling; Data; Dementia; Disease; Family member; Functional Magnetic Resonance Imaging; Funding; Goals; Health Promotion; Image; Impairment; Individual; Interpersonal Relations; Language; Lateral; Lead; Link; Measures; Medial; Memory; Modeling; National Institute on Aging; Neurobiology; Neurocognitive; Parents; Patients; Pattern; Personal Satisfaction; Persons; Play; Prefrontal Cortex; Production; Psychology; Quality of life; Research; Resources; Role; Science; Social Functioning; Social Interaction; Social isolation; Speech; System; Time; United States National Institutes of Health; Voice; Work; autistic children; brain dysfunction; comprehension deficit; design; disability; functional disability; improved; language comprehension; language impairment; mortality risk; negative affect; novel; parent grant; parent project; relating to nervous system; response; reward processing; social communication; speech processing

Project Abstract Alzheimer’s disease (AD) is a progressive and severely debilitating disease that negatively affects cognitive and memory function and is linked to increased disability in everyday functioning and risk of mortality. Language function is a crucial area of impairment for AD. Individuals with AD show a wide range of language difficulties which are thought to lead to social isolation in affected individuals, negatively affecting quality of life and well-being for patients, caregivers, and family members. The major goal of our Administrative Supplement is to advance our understanding of the brain mechanisms underlying speech comprehension deficits in patients with AD. To accomplish this goal, we will leverage fMRI task paradigms and neurocognitive models we have recently developed as part of the parent project and ongoing work in collaboration with the Stanford Alzheimer’s Disease Research Center (ADRC). We now propose to extend our original aims with two new Aims designed to build on these findings by examining anticipatory and integrative components of speech processing, with a focus on aberrant organization of the default mode network, in patients with early AD. Critically, to achieve this goal, we will apply the novel experimental and analytic approaches developed by the parent project at Stanford to AD data collected as part of the proposed supplement and resources provided by the Stanford ADRC (P30AG066515) Clinical Core and Imaging Core. Specifically, we will investigate (1) speaker-listener brain coupling during natural speech communication and its relation to narrative comprehension and functional communication abilities in AD and age-matched healthy controls; and (2) the integrity of temporal integration windows underlying naturalistic verbal communication and its relation to narrative comprehension and functional communication abilities in AD and age-matched healthy controls. Our studies will provide critical information regarding the neurobiological origins of communication impairments in AD and will inform therapies and strategies aimed at improving language and social function in dementia.

项目摘要 阿尔茨海默病 (AD) 是一种进行性且严重使人衰弱的疾病，会对认知能力产生负面影响 和记忆功能，并与日常功能障碍和死亡风险增加有关。 语言功能是 AD 患者受损的一个重要领域。 人们认为这些困难会导致受影响个体的社会孤立，从而对生活质量产生负面影响 以及患者、护理人员和家庭成员的福祉是我们行政补充文件的主要目标。 是为了增进我们对言语理解缺陷背后的大脑机制的理解 为了实现这一目标，我们将利用功能磁共振成像任务范式和神经认知模型。 最近作为父项目的一部分进行了开发，并与斯坦福大学合作进行了持续的工作 阿尔茨海默病研究中心 (ADRC) 现在提议通过两个新的目标来扩展我们的最初目标。 旨在通过检查言语的预期和综合成分来建立这些发现的目标 处理，重点关注早期 AD 患者默认模式网络的异常组织。 至关重要的是，为了实现这一目标，我们将应用由 斯坦福大学的母项目收集 AD 数据作为拟议补充和资源提供的一部分 斯坦福 ADRC (P30AG066515) 临床核心和影像核心 具体来说，我们将研究 (1)。 自然言语交流过程中说者与听者的大脑耦合及其与叙事的关系 AD 和年龄匹配的健康对照者的理解能力和功能性沟通能力；以及 (2) 自然语言交流背后的时间整合窗口的完整性及其与 AD 和年龄匹配的健康对照者的叙事理解和功能性沟通能力。 研究将提供有关沟通障碍的神经生物学起源的关键信息 AD 将为旨在改善痴呆症语言和社会功能的治疗和策略提供信息。

项目成果

Atypical pattern separation memory and its association with restricted interests and repetitive behaviors in autistic children.

自闭症儿童的非典型模式分离记忆及其与受限兴趣和重复行为的关联。

• DOI: 10.1177/13623613231223354
• 发表时间: 2024
• 期刊: Autism : the international journal of research and practice
• 作者: Chen,Lang;Liu,Jin;Kang,JuliaBoram;Rosenberg-Lee,Miriam;Abrams,DanielA;Menon,Vinod
• 通讯作者: Menon,Vinod

Epidural labour analgesia and autism spectrum disorder: is the current evidence sufficient to dismiss an association?

• DOI: 10.1016/j.bja.2021.12.017
• 发表时间: 2022-02-24
• 期刊: BRITISH JOURNAL OF ANAESTHESIA
• 影响因子: 9.8
• 作者: Butwick, Alexander J.;Abrams, Daniel A.;Wong, Cynthia A.
• 通讯作者: Wong, Cynthia A.