Microcircuits underlying murine parental behavior
小鼠父母行为背后的微电路
基本信息
- 批准号:10227959
- 负责人:
- 金额:$ 35.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-14 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAggressive behaviorAgonistic BehaviorAnimalsArchitectureAreaAtlasesBehaviorBehavioralBiophysicsCalciumCaringCell NucleusCellsChild RearingDevelopmentDiagnosisDiagnosticDiseaseDissectionElectrophysiology (science)EndocrineFathersFemaleFunctional disorderFundingGalaninGene ExpressionGenetic TechniquesGenetic TranscriptionGoalsGrantHeadHormonalHormone ReceptorHumanHypothalamic structureImageImpairmentIn SituInfantInfant CareInfanticideLeadMajor Depressive DisorderMedialMediatingMental DepressionMolecularMolecular GeneticsMonitorMothersMotivationMotorMusNeural PathwaysNeuromodulator ReceptorsNeuronsPartner in relationshipPersonal SatisfactionPharmacologyPhysiologicalPopulationPreoptic AreasRegulationResolutionRoleSchizophreniaSliceSocial BehaviorSocial InteractionSpecificityStereotypingSynapsesSystemTherapeuticTranscriptional RegulationTranslatingVariantViralWorkaffiliative behaviorautism spectrum disorderbasebiophysical propertiesbiophysical techniquesburden of illnesscaregivingcell typeexperiencegenetic technologyimaging approachin vivoinnovationmalemicroendoscopemicroendoscopyneglectneural circuitneurobiological mechanismneuromechanismneurophysiologyneuroregulationnovelnovel therapeutic interventionoffspringpuprelating to nervous systemsevere mental illnesssexsocialsocial deficitstherapeutic developmenttoolurocortin
项目摘要
Project Summary/Abstract
Many severe mental disorders with considerable disease burden such Autism Spectrum Disorders,
Schizophrenia, and Major Depressive Disorder are characterized by profound social impairments. At present,
there is little understanding of the origin of these social deficits, and efficient diagnosis and therapeutic options
are lacking. Advanced molecular and genetic techniques make the discovery of specific neural circuits involved
in social behavior possible, facilitating the development of diagnostics and novel therapeutic approaches specific
to disorders with social deficits. We have taken advantage of newly developed molecular, genetic and systems-
levels tools to uncover how specific neural populations and circuits involved in parental care, a social behavior
essential for the survival and well-being of the offspring are regulated according to the animal sex and
physiological status. Male and female mice show either affiliative or agonistic behavior toward infants depending
on prior social experience. In recent work, we uncovered distinct subpopulations of hypothalamic neurons that
are involved in the positive and negative regulation of male and female parenting behavior. The identification of
these cell types with high granularity provides us with unique entry point to further dissect how changes in the
molecular, biophysical and activity dynamics of distinct neuronal populations regulates parental care. We
propose here to exploit the precise cell type identification of neuronal populations involved in the control of
opposing infant-mediated behaviors and use high resolution molecular (Aim 1), neurophysiological (Aim 2) and
systems-level (Aim 3) approaches to dissect the entire circuitry associated with infant-directed social interactions
and to explore how these circuits are modulated by the animal’s sex and physiological state.
项目摘要/摘要
许多严重的精神障碍患有疾病伯恩伯恩这种自闭症谱系障碍,
精神分裂症和重大抑郁症的特征是社会障碍。现在,
对这些社会缺陷的起源以及有效的诊断和治疗选择几乎没有理解
缺乏。先进的分子和遗传技术使涉及的特定神经回路发现
在社会行为中,支持诊断和新型治疗方法的发展
患有社会缺陷的疾病。我们已经利用了新开发的分子,遗传和系统 -
关卡工具,以揭示特定的神经种群和往返父母护理的涉及的社会行为
根据动物性别和
身体状况。雄性和雌性小鼠表现出对婴儿的会员或激动行为,具体取决于
关于先前的社交经验。在最近的工作中,我们发现了下丘脑神经元的不同亚群
参与男性和女性育儿行为的正面和负面调节。识别
这些具有高粒度的细胞类型为我们提供了独特的入口点,以进一步剖析如何改变
不同神经元种群的分子,生物物理和活性动力学调节父母护理。我们
这里的建议探讨了与控制的神经元种群的精确细胞类型识别
相反的婴儿介导的行为并使用高分辨率分子(AIM 1),神经生理学(AIM 2)和
系统级别(AIM 3)方法,以剖析与婴儿指导的社交互动相关的整个电路
并探索这些电路是如何通过动物的性别和身体状态调节的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Catherine Dulac其他文献
Catherine Dulac的其他文献
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{{ truncateString('Catherine Dulac', 18)}}的其他基金
Odor trail tracking: a new paradigm to unveil algorithms and neural circuits underlying active sensation and continuous decision making
气味踪迹追踪:揭示主动感觉和持续决策背后的算法和神经回路的新范例
- 批准号:
10524245 - 财政年份:2022
- 资助金额:
$ 35.61万 - 项目类别:
Molecular and genetic dissection of brain circuits controlling fever
控制发烧的脑回路的分子和遗传解剖
- 批准号:
10373051 - 财政年份:2020
- 资助金额:
$ 35.61万 - 项目类别:
Systems-Level and in Situ Transcriptomics Deconstruction of Neural Circuits Underlying Sensorimotor Transformation in an Innate Behavior
先天行为中感觉运动转化的神经回路的系统级和原位转录组学解构
- 批准号:
10709855 - 财政年份:2020
- 资助金额:
$ 35.61万 - 项目类别:
Molecular and genetic dissection of brain circuits controlling fever
控制发烧的脑回路的分子和遗传解剖
- 批准号:
10589104 - 财政年份:2020
- 资助金额:
$ 35.61万 - 项目类别:
Center for Integrated Multi-modal and Multi-scale Nucleome Research
综合多模式和多尺度核组研究中心
- 批准号:
10678954 - 财政年份:2020
- 资助金额:
$ 35.61万 - 项目类别:
Center for Integrated Multi-modal and Multi-scale Nucleome Research
综合多模式和多尺度核组研究中心
- 批准号:
10269034 - 财政年份:2020
- 资助金额:
$ 35.61万 - 项目类别:
Center for Integrated Multi-modal and Multi-scale Nucleome Research
综合多模式和多尺度核组研究中心
- 批准号:
10458025 - 财政年份:2020
- 资助金额:
$ 35.61万 - 项目类别:
Microcircuits underlying murine parental behavior
小鼠父母行为背后的微电路
- 批准号:
10461107 - 财政年份:2015
- 资助金额:
$ 35.61万 - 项目类别:
Microcircuits underlying murine parental behavior
小鼠父母行为背后的微电路
- 批准号:
9751346 - 财政年份:2015
- 资助金额:
$ 35.61万 - 项目类别:
Microcircuits underlying murine parental behavior
小鼠父母行为背后的微电路
- 批准号:
10674853 - 财政年份:2015
- 资助金额:
$ 35.61万 - 项目类别:
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