Research Program

研究计划

• 批准号: 10225990
• 负责人: Alison Meredith Buttenheim
• 金额: $ 66.76万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10225990
• 关键词: Address; Adherence; American; Area; Artificial Intelligence; Behavior; Cancer Center; Cancer Control; Cancer Control Research Program; Caring; Collaborations; Continuity of Patient Care; Data; Data Pooling; Development; Doctor of Philosophy; Ensure; Evidence based practice; Eye; Funding; Grant; Health; Healthcare; Incubators; Individual; Investments; Laboratories; Lead; Leadership; Learning; Life; Link; Literature; Machine Learning; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measurement; Measures; Methodology; Methods; Mission; Nature; Oral; Outcome; Patients; Pennsylvania; Pilot Projects; Prevention; Process; Psychiatry; Public Health; Quality of Care; Research; Research Activity; Research Personnel; Resources; Scientific Advances and Accomplishments; Talents; Testing; Tobacco Use Cessation; Tobacco use; Universities; Variant; advanced breast cancer; behavioral economics; bone; cancer care; cancer therapy; care delivery; chemotherapy; comparative; compliance behavior; design; evidence base; heuristics; high reward; implementation science; implementation strategy; implementation study; improved; improved outcome; infancy; innovation; insight; lens; multidisciplinary; programs; reduce tobacco use; response; screening; survivorship; symptom management; uptake

The grand challenge addressed by the Penn Implementation Science Center in Cancer Control (ISC3) is to apply insights from behavioral economics to rapidly accelerate the pace at which we deploy evidence-based practices for patients with cancer, thereby improving cancer care quality and outcomes. Our Research Program, led by Drs. Beidas (implementation science expert) and Buttenheim (behavioral economics expert), will oversee the development and testing of implementation strategies within the Implementation Laboratory. Our implementation strategy design and testing approach includes the patient and clinician as targets, and is informed by behavioral economics to ‘nudge’ individuals to make optimal decisions for implementing evidence-based care. The Penn ISC3 is built on three principles. First, implementation science has not leveraged the rich literature from behav- ioral economics, which has elucidated many of the heuristics that underlie decisions and behaviors contributing to suboptimal health outcomes. Approaches from behavioral economics have not been applied systematically alongside implementation science to improve cancer care; these approaches aim to accelerate uptake of evi- dence-based practices. Second, implementation science has not applied methods to fail fast and learn quickly, which we will incorporate through the application of rapid cycle approaches. Third, research to identify mecha- nisms of the implementation strategies to improve uptake of evidence-based practices is in its infancy. The Research Program includes investigators with expertise in implementation science, behavioral economics, can- cer care delivery research, healthcare innovation, measurement, and mixed methods. In the first two years, we propose three Signature Pilot Projects (SPPs) and two Methods Projects that both support the SPPs and ad- vance the science of implementation with an eye towards rapid learning. SPP 1 (Jenssen/Leone) tests patient- and clinician-directed implementation strategies to increase referral to tobacco cessation programs in patients receiving cancer treatment. SPP 2 (Bekelman/Patel) tests patient- and clinician-directed implementation strate- gies to increase use of higher-value bone modifying agents in patients with advanced breast, lung, and prostate cancer. Common methods and measures link these projects to provide pooled data to accomplish our objectives of testing multilevel implementation strategies to elucidate mechanisms and targets. SPP 3 (Bekelman/Rendle), the most exploratory and high-reward SPP, will test a patient-directed implementation strategy that leverages artificial intelligence and machine learning to promote oral chemotherapy adherence and symptom management. Methods Project 1 will develop a toolkit for the application of rapid cycle approaches (Asch/Buttenheim); Methods Project 2 will use qualitative comparative analysis to characterize multilevel contextual variation and mechanisms (Barg/Rendle). The scientific advances to come out of the Research Program will have a significant public health impact, consistent with NCI priorities, by rapidly improving uptake of evidence-based practices to improve cancer care quality and outcomes for millions of Americans with cancer. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

宾夕法尼亚州癌症控制科学中心（ISC3）提出的大挑战是适用 从行为经济学到快速加速我们部署基于证据的实践的洞察力 对于癌症患者，从而改善了癌症护理质量和结果。我们的研究计划，由 博士。 Beidas（实施科学专家）和Buttenheim（行为经济学专家）将监督 实施实验室内实施策略的制定和测试。我们的实施 策略设计和测试方法包括患者和临床作为目标，并通过行为告知 “推动”个人的经济学，以做出实施循证护理的最佳决定。宾夕法尼亚州 ISC3建立在三个原则上。首先，实施科学并未从行为中利用丰富的文献 Ioral Economics，它阐明了许多促进决定和行为的启发式方法 次优健康结果。行为经济学的方法尚未系统地应用 除了实施科学以改善癌症护理；这些方法旨在加速摄取 基于DNCE的实践。其次，实施科学尚未应用方法来快速失败和快速学习， 我们将通过应用快速周期方法进行整合。第三，用于确定机制的研究 改善基于证据实践的实施策略的实施策略仍处于起步阶段。这 研究计划包括具有实施科学专业知识，行为经济学，能力的研究人员 CER护理研究，医疗保健创新，测量和混合方法。在头两年中，我们 提案三个签名试点项目（SPP）和两个支持SPP和AD-的方法 Vance的实施科学，着眼于快速学习。 SPP 1（Jenssen/Leone）测试患者 - 以及临床指导的实施策略，以增加患者的烟草戒烟计划的转诊 接受癌症治疗。 SPP 2（Bekelman/Patel）测试患者和临床指导的实施策略 - gies增加了晚期乳腺癌，肺和前列腺患者的高价值修饰剂的使用 癌症。通用方法和衡量标准链接这些项目以提供汇总数据以实现我们的目标 测试多级实施策略以阐明机制和目标。 SPP 3（Bekelman/Rendle）， 最探索性和最高奖励的SPP将测试以患者为导向的实施策略 人工智能和机器学习以促进口腔化疗依从性和症状管理。 方法1将开发一个工具包，用于应用快速周期方法（ASCH/BUTTENHEIM）；方法 项目2将使用定性比较分析来表征多层次的上下文变化和机制 （Barg/Rendle）。从研究计划中提出的科学进步将具有重要的公共卫生 与NCI优先级一致的影响，通过迅速改善循证实践以改善癌症 数以百万计的癌症的美国人的护理质量和结果。 PHS 398/2590（修订版06/09）页面延续格式页面