Autonomous Grippers in the Gastrointestinal Tract

胃肠道中的自主抓手

• 批准号: 10224191
• 负责人: David H Gracias
• 金额: $ 48.11万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224191
• 关键词: Adherence; Adhesions; Analgesics; Animals; Anti-Inflammatory Agents; Area; Award; Biopsy; Blood; Custom; Data; Development; Devices; Digestive System Disorders; Disease; Drug Delivery Systems; Drug Formulations; Engineering; Ensure; Esophagus; Family suidae; Feces; Funding; Gastroenterologist; Gastrointestinal tract structure; Geometry; Healthcare; Healthcare Systems; Hospitalization; Hour; Human; Inflammatory Bowel Diseases; Injectable; Intervention; Left; Local Therapy; Malignant Neoplasms; Measures; Mechanics; Medical; Medicine; Mesalamine; Methods; Modeling; Mucous Membrane; National Institute of Biomedical Imaging and Bioengineering; Oral; Oral cavity; Patients; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Physiological; Plasma; Polymers; Power Sources; Rectum; Regimen; Research; Robot; Robotics; Route; Scientist; Structure; Techniques; Testing; Therapeutic; Time; Tissues; Ulcerative Colitis; Wireless Technology; base; biliary tract; cancer therapy; cell motility; chemical release; compliance behavior; controlled release; cost; design; dosage; gastrointestinal; grasp; implantable device; improved; innovation; invention; mechanical force; medication administration; miniaturize; novel; porcine model; rectal; residence; soft tissue; technique development

PROJECT SUMMARY Long-term controlled release of drugs has been a problem tackled by medical practitioners, scientists and engineers alike for the past two or three decades. Despite significant efforts in the field, and the introduction of several inventions to the pharmaceutical market, the field suffers from the lack of a technique that involves easy delivery to the gastrointestinal tract (either oral or rectal route), while promising delivery of a drug over several days to weeks. A long lasting delivery mechanism has eluded scientists and engineers over years and is still a topic of active research. Here we propose to continue the development of an innovative method, in which mechanical gripping to the mucosal tissue is used to improve residence time in the GI tract. The mechanical module is tied to a cargo carrying a drug and the formulation can be administered orally or rectally without any expert help. The method will be extremely favorable to improve adherence and compliance to medicine regimens, thus significantly reducing avoidable and unwanted hospitalization. The gripping mechanism that we plan to utilize to improve retention to the gastrointestinal tract, is based on wireless actuation of self-folding robots, that can be engineered to function on administration to the gastrointestinal tract, in an autonomous fashion. We are the forerunners in the field of actuation of miniaturized robots, without any external power source, and have demonstrated the usefulness of these robotic submillimeter scale structures to carry out biopsy in the biliary tree of live pigs. Here we build on our previous results and introduce a drug carrying cargo on the grippers, such that they can be left inside the GI tract for a prolonged duration of one to several days, to maintain the required concentration of the drug for therapy. Along with the development of systemic delivery modules, the proposal also includes the development of techniques to engineer the adhesion of the gripping modules to soft friable tissues, thus promoting the local therapy of cancer. Our highly interdisciplinary team which involves gastroenterologists, engineers and pharmacologists, seek to test these hypotheses in a pig model, that has a similar GI model as humans. In particular we will deliver therapeutic dosage of an analgesic rectally, to achieve release of the drug in the blood plasma of the animal, over several days. The theragrippers and similar devices that can potentially latch onto the mucosal lining, will also be tested on an ulcerative colitis model in pigs to ensure the release of anti-inflammatory drugs like mesalamine.

项目摘要 长期受控释放药物一直是医生，科学家和 在过去的两三十年中，工程师都一样。尽管在该领域做出了巨大努力，并引入了 在制药市场上发明的几种发明，该领域缺乏一种涉及轻松的技术 传递到胃肠道（口腔或直肠途径），同时有望在几个 几天到几周。多年来，长期持久的交付机制使科学家和工程师避免了 积极研究的主题。在这里，我们建议继续开发一种创新方法，其中 机械夹紧到粘膜组织用于改善胃肠道的停留时间。机械 模块与携带药物的货物绑定，并且可以口服或直肠施用配方，而无需任何 专家帮助。该方法将非常有利于提高依从性和依从性 方案，因此大大减少了避免的住院和不必要的住院治疗。 我们计划利用来改善胃肠道的保留率的机制是基于 自我折叠机器人的无线致动，可以在管理上进行设计 胃肠道，以一种自主的方式。我们是微型化驱动领域的先驱 机器人，没有任何外部电源，并证明了这些机器人亚毫米的有用性 在活猪的胆道树上进行活检的规模结构。在这里，我们以我们先前的结果为基础 在握手上引入携带货物的毒品，以便可以将它们留在胃肠道内以进行长时间 一到几天的持续时间，以维持治疗所需的药物浓度。以及 开发系统性交付模块，该提案还包括开发技术 设计了夹杂模块对软易碎组织的粘附，从而促进了癌症的局部治疗。 我们的高度跨学科团队涉及胃肠病医生，工程师和药理学家，试图 在猪模型中测试这些假设，该假设具有与人类相似的gi模型。特别是我们将交付 直肠镇痛药的治疗剂量，以在动物的血浆中释放药物， 在几天内。 Thragrippers和类似的设备可能会锁在粘膜衬里上，将 也可以在猪的溃疡性结肠炎模型上进行测试，以确保释放抗炎药 美曲胺。