Bio-behavioral Research At The Intersection of Cancer and Aging

癌症与衰老交叉点的生物行为研究

• 批准号: 10224107
• 负责人: Jeanne Mandelblatt
• 金额: $ 88.84万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224107
• 关键词: Adverse effects; Affect; Age; Aging; Award; Basic Science; Biological; Cancer Burden; Cancer Survivor; Caring; Chronology; Clinical; Cognitive; Collaborations; Communication; Data; Early Diagnosis; Emotional; Ensure; Funding; Future; Goals; Growth; Heterogeneity; Individual; Intervention Trial; Laboratories; Longevity; Malignant Neoplasms; Modeling; Older Population; Outcome; Policies; Population; Population Sciences; Process; Productivity; Recording of previous events; Research; Research Personnel; Risk; Role; Series; Survivors; Systemic Therapy; Testing; Training Support; Treatment outcome; aged; aging population; biobehavior; cancer care; cohort; data infrastructure; design; experience; experimental study; frailty; functional decline; functional outcomes; high reward; high risk; innovation; interdisciplinary approach; interest; lifestyle factors; lifestyle intervention; malignant breast neoplasm; novel; public health relevance; randomized trial; survivorship; treatment effect

 DESCRIPTION (provided by applicant): We are experiencing unprecedented growth in the numbers of individuals at risk for, or living with cancer due to population aging, greater use of early detection, advances in treatment, and increasing lifespan. By 2030, nearly 50% of the 45 million new cases and 75% of the 20 million cancer survivors will be aged 60 or older ("older"). Most of these older survivors are interested in and will benefit from systemic therapies. However, these treatments often have adverse effects on function, although data are largely from studies with younger survivors. Since only 4% of NCI-funded survivorship research specifically examines outcomes among older survivors, we know little about how the substantial heterogeneity in aging processes ("biological age") affects risk for adverse functional outcomes among those of comparable chronological age. These data are important because they could affect treatment decisions, survivorship care planning, and ability to live independently. This Outstanding Investigator Award will use a bio-behavioral framework to conduct population sciences research at the intersection of cancer and aging to fill these gaps. Data, infrastructure, and established collaborations from an extant NCI-funded older cohort will be leveraged to iteratively build new studies to test novel hypotheses. Such cohorts are the population science equivalent of a basic science laboratory used for a series of experiments. The goals of the high-risk/high-reward studies are to: physical, emotional, social and role function; 1) define long-term trajectories of decline in cognitive, determine bio-behavioral risks for decline; and examine how systemic therapy and lifestyle factors moderate these relationships; 2) conduct exploratory research on biological age markers to determine feasibility and clinical utility for predicting ris and trajectory of functional decline; 3) conduct pilot randomized trials of the impact of lifestyle interventions on biological age markers and functional outcomes; and 4) enhance long-term clinical and policy impact by incorporating data into policy modeling, engaging survivors in design and communication of results, and supporting training. This research is innovative in use of a bio-behavioral framework and inclusion of policy modeling. The findings will move the field forward by shifting the paradigms of research and care for the growing older population; determining whether biological age markers can identify survivors at greatest risk for functional declines; informing future intervention trials; and expanding the limited number of cancer and aging researchers. The PIs history of productivity and strong institutional and collaborative support will ensure that the research will have the intended impact. Overall, the unique population science perspectives of these studies will add important diversity to the multi-disciplinary approaches needed for reducing the burden of cancer in older survivors.

 描述（由申请人提供）：由于人口老龄化、早期检测的广泛应用、治疗的进步以及寿命的延长，我们面临着癌症风险或罹患癌症的人数空前增长，到 2030 年将增长近 50%。 4500 万新病例中的 75% 和 2000 万癌症幸存者中的 75% 年龄在 60 岁或以上（“老年”），这些老年幸存者中的大多数人对系统治疗感兴趣并将受益。尽管数据主要来自对年轻幸存者的研究，但治疗通常会对功能产生不利影响，因为只有 4% 的 NCI 资助的生存研究专门检查了老年幸存者的结果，我们对衰老过程（“生物年龄”）的显着异质性知之甚少。 “）影响了同龄人的不良功能结果的风险。这些数据很重要，因为它们可能影响治疗决策、生存护理计划和独立生活的能力。该杰出研究者奖将使用生物行为框架来对人群进行研究科学研究在癌症和老龄化的交叉点填补这些空白。 现有的 NCI 资助的旧队列建立的合作将被用来迭代地建立新的研究来测试新的假设，这些队列相当于用于一系列实验的基础科学实验室。 /高回报研究旨在：身体、情感、社会和角色功能 1) 定义长期功能； 认知能力下降的轨迹，确定下降的生物行为风险；并研究系统治疗和生活方式因素如何调节这些关系；2）对生物年龄标志物进行探索性研究，以确定预测 RIS 和功能下降轨迹的可行性和临床实用性； 3）对生活方式的影响进行试点随机试验 对生物年龄标记和功能结果的干预；4) 通过将数据纳入政策模型、让幸存者参与结果的设计和交流以及支持培训，增强长期临床和政策影响。行为框架和政策模型的纳入将通过改变不断增长的老年人口的研究和护理范式来推动该领域的发展；确定生物年龄标记是否可以识别功能衰退风险最大的幸存者；扩大癌症和衰老研究人员的有限数量。 PI 的生产力历史以及强大的机构和协作支持将确保该研究产生预期的影响，总体而言，这些研究的独特的人口科学视角将为减轻癌症负担所需的多学科方法增加重要的多样性。年长的幸存者。

项目成果

A Randomized Trial of Telephone-Based Smoking Cessation Treatment in the Lung Cancer Screening Setting.

肺癌筛查中基于电话的戒烟治疗的随机试验。

• DOI: 10.1093/jnci/djac127
• 发表时间: 2022
• 期刊: Journal of the National Cancer Institute
• 作者: Taylor,KathrynL;Williams,RandiM;Li,Tengfei;Luta,George;Smith,Laney;Davis,KimberlyM;Stanton,CassandraA;Niaura,Raymond;Abrams,David;Lobo,Tania;Mandelblatt,Jeanne;Jayasekera,Jinani;Meza,Rafael;Jeon,Jihyoun;Cao,Pianpian;Ander
• 通讯作者: Ander