Developmental Neuroimaging Core

发育神经影像核心

• 批准号: 10224306
• 负责人: JOSHUA S SHIMONY
• 金额: $ 22.44万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-28 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10224306
• 关键词: Animals; Area; Brain; Child; Clinical; Clinical Data; Clinical Research; Clinical Trials; Communities; Consultations; Data; Data Analyses; Data Linkages; Development; Developmental Disabilities; Down Syndrome; Ensure; Environment; Etiology; Evaluation; Faculty; Funding; Genes; Genetic; Genomics; Goals; Grant; Human; Image; Imaging Techniques; Infant; Informatics; Infrastructure; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; International; Intervention; Investigation; Magnetic Resonance Imaging; Measurement; Methodology; Methods; Modality; Motion; Optical Methods; Phenotype; Phenylketonurias; Physiologic pulse; Preparation; Protocols documentation; Research; Research Design; Research Personnel; Resolution; Resources; Rest; Rodent; Sample Size; Sampling; Scanning; Science; Services; Specific qualifier value; Standardization; Structure; Talents; Technology; Training; Translating; Tuberous sclerosis protein complex; United States National Institutes of Health; Universities; Washington; Wolfram Syndrome; animal imaging; autism spectrum disorder; base; brain behavior; clinical care; cohort; computerized data processing; cost efficient; data acquisition; data analysis pipeline; design; flexibility; human imaging; imaging approach; imaging facilities; imaging system; innovation; insight; medical schools; neuroimaging; neuroinformatics; optical imaging; preclinical imaging; preclinical study; rapid growth; relating to nervous system; research study; tool

Developmental Neuroimaging Core Project Summary The Developmental Neuroimaging Core (DNC) has been, and will continue to be, integral to the rapid growth in our understanding of the brain’s structure and function during typical and atypical development. The breadth of DNC activity includes the incorporation of animal imaging through a state-of-the-art preclinical imaging facility and human imaging through a plethora of high-end human imaging systems. The DNC will provide state- of-the art neuroimaging services to maximize the quality and impact of IDD research by Center investigators, to optimize the application of imaging as a translational tool for innovation in prediction and intervention of developmental disabilities, and to provide a range of consultative and analytic services to help new and early stage investigators incorporate imaging research into their research efforts. The DNC will develop innovative neuroimaging methodologies and make them accessible to the large and growing IDDRC@WUSTL investigator community. The Specific Aims of the DNC, which will accelerate advances in neuroimaging, are as follows: (1) To provide services to the IDDRC community that facilitate the use of magnetic resonance imaging and optical imaging techniques in both preclinical and clinical studies. Subaim 1a: Provide high-quality, comprehensive consultation for study design, including sample selection, subject preparation, technological advice, power considerations related to sample size, brain-behavior gene data linkage, and brain-environmental data linkage. Subaim 1b: Conduct cost-efficient data acquisition for IDDRC investigators, including developing subject preparation protocols, specifying acquisition parameters, optimizing imaging quality, and providing all necessary technical support for conducting the scan. Subaim 1c: Provide data processing, informatics, and analytic services to assist the integration of imaging data with genomic, phenotypic and environmental data. (2) Pursue technical developments to advance IDD research. Subaim 2a: Develop and compare resting state functional connectivity MRI methods with optical methods for rodents. Subaim 2b: Optimize clinical MRI data acquisition to meet or exceed research quality to expand its use for research phenotyping.

发育神经影像学核心项目摘要 发育神经影像学核心（DNC）已经并且将继续是快速不可或缺的 我们对典型和非典型发展过程中大脑结构和功能的理解的增长。 DNC活动的广度包括通过最先进的临床前成像掺入动物成像 设施和人类成像通过大量的高端人成像系统。 DNC将提供州 - 艺术神经影像学服务，以最大程度地提高中心研究人员的IDD研究质量和影响 优化成像作为在预测和干预中的创新的转化工具的应用 发育障碍，并提供一系列协商和分析服务，以帮助新的和早期 舞台调查人员将成像研究纳入他们的研究工作。 DNC将发展创新 神经影像学方法，并使它们可以访问大型且不断增长的IDDRC@wustl调查员 社区。 DNC的具体目的将加速神经影像学的进展，如下：（1） 为IDDRC社区提供服务，以促进磁共振成像和光学的使用 临床前和临床研究中的成像技术。 Subaim 1A：提供高质量的全面 研究设计咨询，包括样本选择，主题准备，技术建议，权力 与样本量，脑行为基因数据链接和大脑环境数据链接有关的考虑因素。 Subaim 1B：为IDDRC调查人员进行成本效益的数据获取，包括开发主题 准备协议，指定采集参数，优化成像质量并提供所有必要的 进行扫描的技术支持。 Subaim 1C：提供数据处理，信息和分析服务 帮助将成像数据与基因组，表型和环境数据集成。 （2）追求技术 发展IDD研究的发展。 Subaim 2a：开发和比较静止状态功能连接 具有光学方法的MRI方法。 Subaim 2b：优化临床MRI数据获取以满足或 超过研究质量以扩大其用于研究表型的使用。