Core A: Administrative and Scientific Development Core

核心A：行政和科学发展核心

• 批准号: 10221695
• 负责人: MARK S SMELTZER
• 金额: $ 84.5万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221695
• 关键词: Address; Administrator; Advisory Committees; Arkansas; Basic Science; Center for Translational Science Activities; Centers of Research Excellence; Clinical Sciences; Communicable Diseases; Communication; Complex; Development; Disease; Doctor of Philosophy; Ensure; Environment; Extramural Activities; Faculty; Fostering; Foundations; Funding; Goals; Grant; Growth; Human; Immune response; Immunology; Individual; Inflammatory Response; Infrastructure; Interdisciplinary Study; Journals; Leadership; Manuscripts; Medical; Mentors; Mentorship; Microbiology; Pathogenesis; Pediatric Hospitals; Phase; Positioning Attribute; Process; Publishing; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Science; Scientist; Seasons; Structure; Teacher Professional Development; Therapeutic; Time; United States National Institutes of Health; Universities; Virulence Factors; Work; authority; career; design; experience; interest; member; microbial; mid-career faculty; pathogenic microbe; programs; recruit; success; tenure track

PROJECT SUMMARY/ABSTRACT The first goal for the Center for Microbial Pathogenesis and Host Inflammatory Responses during Phase I was to bring together a group of promising young investigators whose research focuses on the complex interactions among diverse microbial pathogens and their common human host and to provide these investigators with the support structure required to establish productive, independent research careers. The second goal was to build on the success of these investigators to expand the program to include additional investigators whose work is consistent with this underlying theme, thereby achieving the critical mass required to establish a self-sustaining Center of Biomedical Research Excellence. The overarching goal of the Center is to promote the ability of these investigators to address problems in infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory responses, thereby providing the critical foundation required to manipulate these factors in favor of the host. As described in the Overall component of this Phase II renewal application, we have made tremendous progress toward these goals and are now in strong position to transition from a developmental (Phase I) to a growth stage (Phase II). A key component of this transition is our Administrative and Scientific Development Core (Core A). Specifically, Core A will continue to provide administrative, fiscal, and scientific support for the Center (Aim 1), foster the scientific growth of its investigators through mentoring and faculty development (Aim 2), and foster growth and expansion of the Center through the recruitment of new investigators and facilitating collaborative and synergistic interactions both within the Center and more broadly on the host campuses at large (Aim 3). To these ends, Core A will rely on a seasoned administrative team, the advice of both Internal and External Advisory Committees, and experienced mentors for each Center investigator. The Core's leadership team has fostered the success of Phase I Project Leaders and developed a robust pipeline of new investigators, and during Phase II steps will be taken to ensure the success of these new Project Leaders, promote the continued success of Phase I Project Leaders who obtained R01 funding, maintain the pipeline of new Center investigators, and promote development of collaborative and synergistic research relationships among Center investigators themselves and other scientists on the host campuses (University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute) with common research interests. Success will be judged by the ability to achieve the following milestones in Phase II: 1) obtain no fewer than five new R01- level grants, 2) have at least two Phase I Project Leaders renew grants, 3) publish 25–50 manuscripts in high- impact journals, and 4) have a P01 submitted that includes two or more Center investigators.

项目概要/摘要 微生物发病机制和宿主炎症反应中心第一阶段的第一个目标 是聚集一群有前途的年轻研究人员，他们的研究重点是复杂的 不同微生物病原体与其共同人类宿主之间的相互作用，并提供这些 研究人员拥有建立富有成效的、独立的研究职业所需的支持结构。 第二个目标是在这些调查人员的成功基础上扩大该计划以包括更多 其工作与这一基本主题一致的研究人员，从而达到所需的临界质量 建立一个自我维持的生物医学研究卓越中心 该中心的总体目标是。 提高这些研究人员以治疗方法解决传染病问题的能力 通过了解导致疾病过程的微生物毒力因素来了解相关时尚 以及这些因素如何影响宿主的免疫和炎症反应，从而提供 如总体中所述，操纵这些因素以有利于宿主所需的关键基础。 作为第二阶段更新申请的一部分，我们在实现这些目标方面取得了巨大进展，并且 现在处于从发展阶段（第一阶段）过渡到成长期（第二阶段）的有利位置。 这一转变的组成部分是我们的行政和科学发展核心（核心 A）。 A 将继续为中心提供行政、财政和科学支持（目标 1），促进科学发展 通过指导和教师发展（目标 2）促进研究人员的成长，并促进成长和 通过招募新的调查员以及促进和协作来扩大该中心 中心内部以及整个主办校园内更广泛的协同互动（目标 3）。 为了实现这些目标，核心 A 将依靠经验丰富的管理团队、内部和外部的建议 核心的领导团队拥有咨询委员会和经验丰富的导师。 促进第一阶段项目领导者的成功，并开发了强大的新研究人员渠道，以及 在第二阶段，将采取措施确保这些新项目负责人的成功，促进持续的 一期项目负责人成功获得R01资金，维持新中心的管道 研究人员，并促进中心之间合作和协同研究关系的发展 研究人员本人和主办校园的其他科学家（阿肯色大学医学院） 科学和阿肯色州儿童医院研究所）有共同的研究兴趣将会成功。 通过在第二阶段实现以下里程碑的能力来判断：1）获得不少于五个新的R01- 级资助，2）至少有两名第一阶段项目负责人续签资助，3）在高水平领域发表 25-50 篇手稿 影响力期刊，4) 提交的 P01 包含两名或两名以上中心调查员。