Effects of DLPFC tDCS on Cognition, Oscillations and GABA Levels in Schizophrenia

DLPFC tDCS 对精神分裂症认知、振荡和 GABA 水平的影响

• 批准号: 10219922
• 负责人: Cameron S. Carter
• 金额: $ 47.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-12 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219922
• 关键词: Address; Adult; Affect; Anodes; Area; Attention; Behavioral Paradigm; Biological; Brain; Cognition; Cognitive deficits; Data; Development; Disease; Dose; Economic Burden; Electrophysiology (science); Equilibrium; Expectancy; Failure; Functional disorder; Goals; Human; Impaired cognition; Impairment; Individual; Intuition; Link; Literature; Magnetic Resonance Spectroscopy; Maintenance; Measures; Mediation; Mental disorders; Meta-Analysis; Methods; Modeling; National Institute of Mental Health; Occipital lobe; Occupational; Outcome; Pattern; Performance; Prefrontal Cortex; Process; Research; Rest; Role; Schizophrenia; Site; Specificity; Task Performances; Techniques; Testing; Time; Work; base; brain circuitry; cognitive control; cognitive disability; cognitive neuroscience; cognitive performance; cognitive task; daily functioning; design; effective therapy; efficacy testing; electric field; frontal lobe; gamma-Aminobutyric Acid; improved; insight; neural network; neuroimaging; neuromechanism; noninvasive brain stimulation; psychotic symptoms; relating to nervous system; social; support network; therapy development; tool

PROJECT SUMMARY/ABSTRACT Cognitive control deficits are associated with poor functioning in schizophrenia (SZ). These deficits include an impaired ability to maintain task-relevant goals and attention to a task over time, and are connected to impaired functioning of the dorsolateral prefrontal cortex (DLPFC), a key hub in the neural network supporting cognitive control. The proposed research uses a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS) to test a set of mechanistic hypotheses about the role of the DLPFC in cognitive control deficits in SZ, focusing on stimulation-induced changes in neural oscillations and DLPFC GABA levels. To do so, we will use DLPFC-targeted tDCS in combination with electrophysiology (EEG) and magnetic resonance spectroscopy (MRS) methods to examine stimulation-induced changes in neural activity related to cognitive control in SZ. Preliminary data from our lab suggests that DLPFC-targeted anodal tDCS can enhance neural oscillations that support goal maintenance in both healthy controls and individuals with SZ. This neurostimulation approach offers an exciting new avenue for understanding the neural mechanisms underlying impaired cognition in SZ, which we propose to utilize with three specific aims. Aim 1: Compare the effects of task-engaged versus resting tDCS in order to optimize the impact of tDCS on goal maintenance related neural oscillatory activity and task performance in SZ. Aim 2: Establish the regional specificity of the impact of DLPFC tDCS (compared to Occipital tDCS) effects on brain circuitry underlying goal maintenance in SZ. Aim 3: Test hypotheses about relationships between tDCS effects on DLPFC GABA levels, DLPFC-related oscillatory activity and cognitive performance in SZ. Successful completion of these Aims will address critical gaps in the literature on cognitive disability in SZ, which has, to date, relied on correlative approaches and will provide new insights into the role of disrupted DLPFC related brain circuity in SZ and its underlying pathophysiological mechanisms. It will also provide important new insights into the mechanisms of tDCS effects on brain and cognition in this illness.

项目摘要/摘要 认知控制缺陷与精神分裂症（SZ）的功能不佳有关。这些缺陷包括 随着时间的推移，保持与任务相关的目标和对任务的关注的能力受损，并连接到受损 背外侧前额叶皮层（DLPFC）的功能，这是一个支持认知的神经网络中的关键中心 控制。拟议的研究使用非侵入性大脑刺激技术，经颅直流电流 刺激（TDC）测试有关DLPFC在认知控制中作用的一组机械假设 SZ缺陷，重点是刺激引起的神经振荡和DLPFC GABA水平的变化。做 因此，我们将使用DLPFC靶向的TDC与电生理学（EEG）和磁共振结合 光谱法（MRS）方法检查刺激引起的与认知有关的神经活动变化 在SZ中控制。我们实验室的初步数据表明，靶向DLPFC的阳极TDC可以增强神经 支持健康控制和SZ个体的目标维持目标的振荡。这 神经刺激方法为理解神经机制的神经机制提供了令人兴奋的新途径 SZ中的认知受损，我们建议以三个特定目标使用。目标1：比较 任务参与与休息的TDC，以优化TDC对目标维护相关神经的影响 SZ中的振荡活动和任务性能。目标2：建立DLPFC影响的区域特异性 TDC（与枕骨TDC相比）对SZ中脑电路的影响。目标3：测试 关于TDC对DLPFC GABA水平的关系，与DLPFC相关的振荡的假设 SZ的活动和认知表现。这些目标的成功完成将解决 SZ中有关认知障碍的文献，迄今为止，该文献依赖相关方法并将提供新的方法 洞悉SZ中DLPFC相关的脑循环的作用及其潜在的病理生理学 机制。它还将为TDCS对大脑的影响的机制提供重要的新见解 这种疾病的认知。