Core B. Clinical Translational Core

核心 B. 临床转化核心

• 批准号: 10220102
• 负责人: Sally Ozonoff
• 金额: $ 32.45万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10220102
• 关键词: Address; Age; Assessment tool; Behavioral; Biological; California; Characteristics; Childhood; Chromosomes; Clinical; Clinical Trials; Collection; DiGeorge Syndrome; Diagnostic; Dimensions; Disease; Doctor of Philosophy; Down Syndrome; Economics; Ensure; Ethnic Origin; Evaluation; Failure; Fragile X Syndrome; Freezing; Funding; Genetic; Genomic medicine; Genomics; Health; Health Technology; Heterogeneity; Human; Incentives; Individual; Infrastructure; Institutes; Intellectual and Developmental Disabilities Research Centers; Investigation; Lead; Libraries; Link; Measures; Methodology; Molecular Analysis; Monitor; Mood Disorders; National Institute of Child Health and Human Development; Participant; Patient Recruitments; Phenotype; Population; Problem Solving; Process; Productivity; Race; Registries; Research; Research Personnel; Resources; Science; Scientist; Services; Site; Standardization; Symptoms; Technology; Testing; Training; Translations; Universities; Variant; Venous blood sampling; autism spectrum disorder; biobehavior; community engagement; comorbidity; comparison group; cost; cost effective treatment; cost effectiveness; design; experience; improved; inclusion criteria; innovation; interest; neurobehavioral; neuropathology; patient engagement; programs; psychologic; recruit; standardize measure; telehealth; tool

PROJECT SUMMARY – CLINICAL TRANSLATIONAL CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The Clinical Translational Core (CTC) is designed to establish and maintain an operational framework that is optimal for recruitment, diagnostic assessment, neurobehavioral characterization, and mapping of phenotypes to underlying biological mechanisms for a diverse range of clinical populations. The CTC will address five specific aims. Aim 1 is to enhance recruitment of a diverse range of participants. This aim will be met through systematic community engagement and a growing participant registry that includes multiple ethnicities, races, and economic backgrounds with both atypical and typical populations across a wide age span. Aim 2 is to provide behavioral and diagnostic characterization of human participants. This aim will be met by providing access to experienced clinicians who can conduct specialized evaluations, advise studies in best practices, provide training in administration of standardized measures, establish initial reliability, and monitor administration fidelity, as well as by providing access to specialized testing space and connect investigators with clinical trials expertise. Aim 3 is to provide access to state-of-the-art “deep phenotyping” tools and expertise in genomics. This aim will be met by offering tools and training to enhance phenotypic characterization of participants, making available recent innovations in deep phenotyping and genomics to IDDRC investigators. Aim 4 is to support the integration of technology into research, especially telehealth methodologies that can lead to scalable, accessible, and cost-effective treatments for IDD conditions. This aim will be met by providing on-site high-level research IT support and access to the full array of technologies and expertise at UC Davis Health. Aim 5 is to facilitate collection and analysis of biospecimens from human participants and promote sharing across IDDRC projects. This aim will be met by providing phlebotomy services and access and incentives to use a core-managed freezer library for biospecimen storage as well as by links to the MIND IDDRC Biological and Molecular Analysis Core and the MIND Institute Genomic Medicine Program. The proposed CTC has been significantly expanded relative to the previous funding period, with the most significant change being the integration of the deep phenotyping and measure dissemination functions of the previous Neurobehavioral Analysis Core, which has led us to rename this expanded core, the CTCx. The Director of the CTC is Sally Ozonoff, PhD.

项目摘要 - 临床翻译核心 本申请寻求资金来继续思维学院的知识和发展 加州大学戴维斯分校的残疾研究中心（IDDRC）。 IDDRC于2013年启动 并且是网络中14个IDDRC中的最新一个。临床翻译核心（CTC）旨在建立 并保持最佳招聘，诊断评估，神经行为的操作框架 表征和将表型映射到潜水员临床范围的潜在生物学机制 人群。 CTC将解决五个具体目标。目的1是增强潜水员范围的招聘 参与者。这个目标将通过系统的社区参与和不断增长的参与者注册表来实现 其中包括多种种族，种族和经济背景，具有非典型人群和典型人群 目标2是提供人类参与者的行为和诊断表征。 通过提供可以进行专门评估的经验丰富的临床医生的访问，可以实现此目标 最佳实践的咨询研究，提供标准化措施的管理培训，建立初始 可靠性和监控管理保真度，以及通过提供专业测试空间的访问权限和 将研究人员与临床试验专业知识联系起来。 AIM 3是提供对最先进的访问权限的访问 表型”基因组学方面的工具和专业知识。将通过提供工具和培训来增强该目标 参与者的表型表征，使深度表型的最新创新和 IDDRC研究人员的基因组学。目标4是支持技术集成到研究中，尤其是 可以为IDD条件提供可扩展，可访问且具有成本效益的治疗方法的远程医疗方法。 通过提供支持的现场高级研究并访问一系列的现场高级研究，将实现此目标 UC Davis Health的技术和专业知识。目标5是促进生物测量的收集和分析 来自人类参与者并促进跨IDDRC项目共享。通过提供这个目标 静脉切开术以及使用核心管理的冰柜图书馆进行生物循环存储的访问和激励措施 以及通过链接到Mind IDDRC生物学和分子分析核心以及Mind Institute基因组 医学计划。相对于以前的资金期，拟议的CTC已大大扩展 最重要的变化是深度表型和测量传播的整合 先前神经行为分析核心的功能，这使我们重命名了扩展的核心， CTCX。 CTC的主任是Sally Ozonoff博士。