Mentoring in prevention of hospital-acquired infections and antibiotic resistance

指导预防医院获得性感染和抗生素耐药性

基本信息

批准号：
10289714
负责人：
AARON M MILSTONE
金额：
$ 17.54万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-11-23 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10289714
关键词：
Admission activity Antibiotic Resistance Antibiotic-resistant organism Antibiotics Area Bacterial Genes Biodiversity Blood Categories Characteristics Childhood Clinical Collaborations Communicable Diseases Critically ill children Data Epidemiologist Epidemiology Funding Future Genes Goals Health Health Policy Health system Healthcare Hospitals Human Incontinence Infection Infection prevention Intensive Care Units Intervention Knowledge Laboratories Measures Mentors Modeling Molecular Nose Nosocomial Infections Organism Parents Patients Pediatric Intensive Care Units Physicians Plague Population Predisposition Prevention Production Research Research Infrastructure Research Personnel Resistance Resistance to infection Risk Risk Factors Role Sampling Science Source Staphylococcus aureus Talents Testing Time Training Programs Translating Universities Virulence Vulnerable Populations bacterial community carbapenem resistance carbapenemase care delivery career cohort emerging antibiotic resistance genome sciences healthcare-associated infections high risk implementation science improved knowledge base microbial community microbiome microbiome components microbiome research neonate next generation novel strategies patient oriented research patient population post-doctoral training pre-doctoral predictive modeling prevent programs public health priorities repository resistance mechanism transmission process

项目摘要

Despite technological advances and improved care delivery, antibiotic resistance and healthcare associated infections continue to plague our health system. The applicant, Dr. Aaron Milstone, is a Pediatric Infectious Diseases Physician and Epidemiologist who had focused his career on the prevention of antibiotic resistance and healthcare-associated infections. This K24 application builds on his career goals of translating laboratory and epidemiologic observations into patient- and population-level interventions and will prepare him and his trainees to identify, develop, and test new strategies to prevent infections and antibiotic resistance. The specific research aims are to: 1) identify risk factors for and develop a predictive model of carbapenem- resistant organism colonization and transmission in hospitalized patients, 2) identify bacterial communities, bacterial genes, and patient clinical characteristics associated with resistance to S. aureus nasal colonization in hospitalized neonates at risk for S. aureus acquisition from parents with known S. aureus colonization, and 3) determine whether bacterial culture stewardship reduces antibiotic use and resistance. The proposed projects will build on existing funded projects and collaborations in microbiome, genomics, and implementation science, expand the Dr. Milstone's knowledge in these areas, and make him a more effective PI and patient oriented research mentor.

尽管技术进步并改善了护理能力，抗生素耐药性和与医疗保健相关感染继续困扰我们的卫生系统。申请人亚伦·米尔斯通（Aaron Milstone）博士是儿科感染性的疾病医师和流行病学家，他的职业生涯将其职业放在预防抗生素抗性上和医疗保健相关的感染。这个K24的应用是基于他翻译实验室的职业目标以及对患者和人口水平干预措施的流行病学观察，并将为他和他的他的准备做好准备识别，制定和测试新策略以防止感染和抗生素耐药性的新策略。这具体研究的目的是：1）确定碳青霉烯的危险因素并开发一种预测模型耐药的生物体定植和住院患者的传播，2）识别细菌群落，细菌基因和患者的临床特征与抗性金黄色葡萄球菌定植有关在住院的新生儿中，有金黄色葡萄球菌殖民的父母有金黄色葡萄球菌的风险，并 3）确定细菌培养的管理是否会降低抗生素的使用和耐药性。提议项目将建立在现有资助的项目和微生物组，基因组学和实施方面的合作科学，扩大米尔斯通博士在这些领域的知识，使他成为更有效的PI和耐心定向研究导师。