Understanding the effect of waterpipe size on smoking behavior, toxicant exposures and subjective experiences

了解水烟尺寸对吸烟行为、毒物暴露和主观体验的影响

基本信息

批准号：
10287653
负责人：
Ziyad Ben Taleb
金额：
$ 7.7万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10287653
关键词：
Affect Behavior Carbon Monoxide Cardiopulmonary Cigarette Clinical Cross-Over Studies Data Devices Dimensions Drug usage Enrollment Epidemic Evaluation Exhalation Exposure to Height In Vitro Individual Inhalation Intoxication Laboratories Laboratory Research Lead Length Malignant neoplasm of lung Marketing Measurement Measures Methods Minnesota Mission Modeling National Institute of Drug Abuse Nicotine Nicotine Dependence Nicotine Withdrawal Outcome Participant Perception Poisoning Public Health Pulmonary Heart Disease Questionnaires Regulation Reporting Research Research Design Route Sales Saliva Science Sensory Smoker Smoking Smoking Behavior Testing Texas Time Factors Tobacco Tobacco smoking behavior Toxicant exposure United States United States Food and Drug Administration Universities carbon emissions cardiovascular disorder risk cigarette smoking college combustible cigarette craving design experience health assessment hookah improved innovation nicotine exposure novel prevent respiratory satisfaction tobacco products toxicant university student young adult

项目摘要

Waterpipe (WP) tobacco smoking—also known as hookah—continues to be a popular method of tobacco smoking in the United States (US), particularly among young adults. Similar to cigarettes, accumulating evidence shows that WP smoking can lead to nicotine dependence, lung cancer and cardiopulmonary diseases. Recognizing the seriousness of the WP epidemic in the US, the Food and Drug Administration (FDA) now regulates the manufacture, sale, and distribution of WP products, including the different components and configurations of the WP device. However, regulations specific to WP remains limited. One of the main regulatory routes with great potential for WP control is the size of the WP device. Compared with traditional cigarettes that are manufactured in standard sizes, WPs are available in many sizes that can vary significantly in pipe height and bowl volume. Converging lines of evidence regarding the toxicant exposure associated with WP smoking indicate that WP size is an important factor in determining exposures to carbon monoxide (CO) and other toxicant emissions. In addition, there is a prevailing public misconception regarding the perception of harm attributed to WP smoking. The majority of WP smokers believe that WP is less addictive and less harmful than cigarette smoking. Such misconceptions are reinforced by the marketing of smaller sizes of WP. In fact, many online WP retailers in the US advertise small WPs (aka, mini hookahs) as “excellent choice for a first hookah” and “best hookahs for beginners” which make them appear like perfect “starter sizes” for otherwise WP-naïve individuals. Therefore, it is logical that the dimensions of the WP itself will influence harm perception and smoking behavior and in turn will alter the levels of exposure to toxicants such as CO and nicotine among WP smokers. However, empirical evidence regarding the effect of WP size–a key question from a regulatory standpoint–on WP smokers' experiences and exposures continues to be lacking. In this project, we will assess the effect of WP size on smoking behavior, toxicant exposures and subjective experiences among WP smokers. We hypothesize that smoking a smaller size WP will lead to a more pronounced effect on puffing parameters, exposure to CO and nicotine, harm perception, satisfaction and craving compared to smoking a larger size WP. We will enroll 40 young adult WP smokers (21-39 years) to undergo a 2X3 crossover study design, where the within-subject factors are time (pre-post WP smoking) and study condition (small WP vs. medium WP vs. large WP). Accordingly, each participant will complete three independent sessions of WP smoking (45 min each) that differ by WP size, while measurement of puff topography, subjective experiences, harm perception, and exposure to nicotine and CO will be conducted. This project is innovative because it will provide the first evidence to guide the FDA in terms of the potential impact of regulating WP size on smokers’ experiences and exposures. Most importantly, this project will help the FDA in developing size-specific regulatory standards to control the marketing and sales of WP devices and to protect public health.

水烟 (WP) 吸烟（也称为水烟）仍然是一种流行的吸烟方法美国的吸烟情况，尤其是年轻人的吸烟情况，与香烟类似，正在积累证据。研究表明，吸烟可导致尼古丁依赖、肺癌和心肺疾病。美国食品和药物管理局 (FDA) 认识到 WP 疫情的严重性规范 WP 产品的制造、销售和分销，包括不同的组件和然而，针对 WP 的具体法规仍然有限。与传统卷烟相比，WP控制路线的巨大潜力在于WP装置的尺寸。按标准尺寸制造，WP 有多种尺寸可供选择，管道高度可能有很大差异和碗容量有关与 WP 吸烟相关的毒物暴露的证据。表明 WP 大小是决定接触一氧化碳 (CO) 和其他有毒物质的重要因素此外，公众对排放造成的危害普遍存在误解。大多数吸食 WP 的人认为，与香烟相比，WP 的成瘾性和危害性更小。事实上，许多在线可湿性粉剂的营销强化了这种误解。美国的零售商将小型 WP（又名迷你水烟袋）宣传为“第一支水烟袋的最佳选择”和“最佳水烟袋”。适合初学者的水烟袋”，这使得它们对于那些不懂水烟的人来说看起来像是完美的“入门尺寸”。因此，WP本身的维度会影响危害感知和吸烟行为是合乎逻辑的进而会改变 WP 吸烟者接触 CO 和尼古丁等有毒物质的水平。关于 WP 规模影响的经验证据（监管立场的一个关键问题）对 WP 的影响在这个项目中，我们将评估吸烟者的经历和接触的影响。 WP 大小对 WP 吸烟者吸烟行为、有毒物质暴露和主观体验的影响。研究发现，吸食较小尺寸的可湿性粉剂会对抽吸参数产生更明显的影响，与吸食较大尺寸的可湿性粉剂相比，接触一氧化碳和尼古丁会损害感知、满足感和渴望。我们将招募 40 名年轻的成年 WP 吸烟者（21-39 岁）进行 2X3 交叉研究设计，其中受试者内因素包括时间（WP 前吸烟）和研究条件（小 WP 与中 WP 与大 WP）因此，每位参与者将完成三个独立的 WP 吸烟课程（每次 45 分钟）。因 WP 大小而异，而对粉扑地形、主观体验、伤害感知和该项目具有创新性，因为它将提供第一个证据。就调节可湿性粉剂大小对吸烟者经历和暴露的潜在影响向 FDA 提供指导。最重要的是，该项目将帮助 FDA 制定特定尺寸的监管标准来控制 WP 设备的营销和销售以及保护公众健康。