Understanding the effect of waterpipe size on smoking behavior, toxicant exposures and subjective experiences

了解水烟尺寸对吸烟行为、毒物暴露和主观体验的影响

• 批准号: 10579171
• 负责人: Ziyad Ben Taleb
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579171
• 关键词: Affect; Behavior; Carbon Monoxide; Cardiopulmonary; Cigarette; Clinical; Cross-Over Studies; Data; Devices; Dimensions; Drug usage; Enrollment; Epidemic; Evaluation; Exhalation; Exposure to; Height; In Vitro; Individual; Inhalation; Intoxication; Laboratories; Laboratory Research; Length; Malignant neoplasm of lung; Marketing; Measurement; Measures; Methods; Minnesota; Mission; Modeling; National Institute of Drug Abuse; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Outcome; Participant; Perception; Poisoning; Proliferating; Public Health; Pulmonary Heart Disease; Questionnaires; Regulation; Reporting; Research; Research Design; Route; Sales; Saliva; Science; Sensory; Smoker; Smoking; Smoking Behavior; Testing; Texas; Time Factors; Tobacco; Tobacco smoking behavior; Toxicant exposure; United States; United States Food and Drug Administration; Universities; carbon emissions; cardiovascular disorder risk; cigarette smoking; college; combustible cigarette; craving; design; experience; health assessment; hookah; improved; innovation; manufacture; nicotine exposure; novel; prevent; respiratory; satisfaction; tobacco products; toxicant; university student; young adult

Waterpipe (WP) tobacco smoking—also known as hookah—continues to be a popular method of tobacco smoking in the United States (US), particularly among young adults. Similar to cigarettes, accumulating evidence shows that WP smoking can lead to nicotine dependence, lung cancer and cardiopulmonary diseases. Recognizing the seriousness of the WP epidemic in the US, the Food and Drug Administration (FDA) now regulates the manufacture, sale, and distribution of WP products, including the different components and configurations of the WP device. However, regulations specific to WP remains limited. One of the main regulatory routes with great potential for WP control is the size of the WP device. Compared with traditional cigarettes that are manufactured in standard sizes, WPs are available in many sizes that can vary significantly in pipe height and bowl volume. Converging lines of evidence regarding the toxicant exposure associated with WP smoking indicate that WP size is an important factor in determining exposures to carbon monoxide (CO) and other toxicant emissions. In addition, there is a prevailing public misconception regarding the perception of harm attributed to WP smoking. The majority of WP smokers believe that WP is less addictive and less harmful than cigarette smoking. Such misconceptions are reinforced by the marketing of smaller sizes of WP. In fact, many online WP retailers in the US advertise small WPs (aka, mini hookahs) as “excellent choice for a first hookah” and “best hookahs for beginners” which make them appear like perfect “starter sizes” for otherwise WP-naïve individuals. Therefore, it is logical that the dimensions of the WP itself will influence harm perception and smoking behavior and in turn will alter the levels of exposure to toxicants such as CO and nicotine among WP smokers. However, empirical evidence regarding the effect of WP size–a key question from a regulatory standpoint–on WP smokers' experiences and exposures continues to be lacking. In this project, we will assess the effect of WP size on smoking behavior, toxicant exposures and subjective experiences among WP smokers. We hypothesize that smoking a smaller size WP will lead to a more pronounced effect on puffing parameters, exposure to CO and nicotine, harm perception, satisfaction and craving compared to smoking a larger size WP. We will enroll 40 young adult WP smokers (21-39 years) to undergo a 2X3 crossover study design, where the within-subject factors are time (pre-post WP smoking) and study condition (small WP vs. medium WP vs. large WP). Accordingly, each participant will complete three independent sessions of WP smoking (45 min each) that differ by WP size, while measurement of puff topography, subjective experiences, harm perception, and exposure to nicotine and CO will be conducted. This project is innovative because it will provide the first evidence to guide the FDA in terms of the potential impact of regulating WP size on smokers’ experiences and exposures. Most importantly, this project will help the FDA in developing size-specific regulatory standards to control the marketing and sales of WP devices and to protect public health.

水烟（WP）烟草吸烟（也称为水烟）是一种流行的烟草方法 在美国（美国）吸烟，尤其是在年轻人中。类似于香烟，积累证据 表明WP吸烟会导致尼古丁依赖性，肺癌和心肺疾病。 现在认识到美国WP流行的严重性，现在是美国食品和药物管理局（FDA） 调节WP产品的制造，销售和分销，包括不同的组件和 WP设备的配置。但是，特定于WP的法规仍然有限。主要监管之一 WP控制可能具有很大潜力的路线是WP设备的大小。与传统香烟相比 由标准尺寸制造，WPS可用多种尺寸，可以在管道高度上有很大差异 和碗体积。关于与WP吸烟有关的毒物暴露的证据线的融合线 表明WP大小是确定对一氧化碳（CO）和其他有毒物质暴露的重要因素 排放。此外，关于归因于伤害的看法，存在普遍的公众误解 WP吸烟。大多数WP吸烟者认为WP的添加剂和危害不如香烟 吸烟。通过较小尺寸的WP的营销来加强这种误解。实际上，许多在线WP 美国的零售商宣传小型WPS（又名迷你烟囱）是“第一个水烟的绝佳选择”和“最好的选择 初学者的水烟”使它们看起来像是完美的“入门尺寸”，对于其他人来说，它们看起来像是“入门尺寸”。 因此，合乎逻辑的是，WP本身的尺寸会影响伤害感知和吸烟行为 反过来，WP吸烟者中会改变对毒物和尼古丁等有毒物质的暴露水平。然而， 关于WP大小的效果的经验证据 - 从监管的角度来看，WP的关键问题 吸烟者的经历和暴露仍然缺乏。在这个项目中，我们将评估 WP大小对吸烟行为，有毒物质暴露和WP吸烟者的主题经验。我们 假设吸烟较小的WP会导致对浮肿参数的更明显影响， 与吸烟较大的WP相比，暴露于CO和尼古丁，危害感知，满意度和渴望。 我们将注册40名年轻的WP吸烟者（21-39岁），以进行2x3的跨界研究设计，其中 受试者内部因素是时间（PES POST WP吸烟）和研究条件（小WP与中等WP与大型 WP）。根据每个参与者的说法，将完成三个独立的WP吸烟（每人45分钟） WP大小的差异，同时测量粉扑地形，主题经验，伤害感知和 接触尼古丁和CO。该项目具有创新性，因为它将提供第一个证据 指导FDA，以确定WP规模对吸烟者的体验和暴露的潜在影响。 最重要的是，该项目将帮助FDA制定特定于尺寸的监管标准，以控制 WP设备的营销和销售并保护公共卫生。

项目成果

High on Hookah: Smoking Marijuana from a Hookah among Adults in the United States, Population Assessment of Tobacco and Health Study, 2015-2019.

高吸水烟：美国成年人通过水烟吸食大麻，烟草人口评估与健康研究，2015-2019 年。

• DOI: 10.1080/10826084.2023.2177966
• 发表时间: 2023
• 期刊: Substance use & misuse
• 影响因子: 2
• 作者: EbrahimiKalan,Mohammad;Jebai,Rime;Li,Wei;Gautam,Prem;Osibogun,Olatokunbo;Alqahtani,MohammedM;Ward,KennethD;Behaleh,Raed;Bursac,Zoran;BenTaleb,Ziyad
• 通讯作者: BenTaleb,Ziyad