2021 Wnt Signaling GRC/GRS

2021 Wnt 信号 GRC/GRS

• 批准号: 10229196
• 负责人: KENNETH M CADIGAN
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10229196
• 关键词: Address; Anger; Animal Model; Biochemistry; Biological; Biological Process; Biology; Biomedical Research; Canada; Collaborations; Complex; Development; Developmental Process; Disease; Fishes; Future; Glean; Goals; Homeostasis; Individual; Lead; Life; Location; Malignant Neoplasms; Methodology; Michigan; Molecular; Mus; Natural regeneration; Netherlands; Organoids; Pathway interactions; Postdoctoral Fellow; Rana; Regulation; Research; Research Personnel; Role; Scientist; Signal Pathway; Signal Transduction; Spain; Structural Biologist; Structure; Therapeutic; Therapeutic Intervention; Tissue Engineering; Tissues; Touch sensation; Universities; WNT Signaling Pathway; Wnt proteins; age related; biological systems; career; design; developmental disease; educational atmosphere; field study; fly; graduate student; human disease; insight; meetings; method development; novel; novel therapeutic intervention; posters; stem cell biology; stem cells; symposium; therapeutic target

Project Summary We request partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) titled ““Wnt Signaling: Molecular Mechanisms, Development andTtissue Homeostasis, and Therapeutics” to be held August 1-6, 2021 at the Rey Don Jaime Grand Hotel in Castelldefels, Spain. This meeting will be chaired by Stephane Angers (University of Toronto, Canada) and Mariann Bienz (MRC, UK) with Ken Cadigan (University of Michigan, USA) and Madelon Maurice (UMC Utrecht, Netherlands) as Vice-Chairs., and will include presentations from many prominent scientists, at varied career stages, active in the field of Wnt biology. The GRS will be held at the same location July 31-August 1, 2021 and will feature talks from up and coming graduate students and postdoctoral fellows and will be led by postdoctoral fellows Rony Chidiac (University of Toronto) and Pooja R. Sonavane (USCD). The specific aim of the conference is to provide a forum for the presentation and discussion of recent advances and new ideas in all aspects of Wnt biology. Progress in this field has consistently accelerated and has touched on countless biological processes in all metazoan life forms. In addition, the Wnt pathway is widely recognized as a critical regulator of tissue homeostasis, and, consequently, its de-regulation is associated with many disorders, from early developmental abnormalities to age-related diseases, such as cancer. Session topics have been selected on the basis of their potential impact on the key current scientific questions in development, stem cell biology and cancer. The meeting is structured to include sessions on the mechanisms of Wnt signal transduction, structure and function of Wnt signaling, Wnt signaling in tissue engineering and organoids, Wnt signaling in diseases, Wnt signaling in Development, bcatenin-independent Wnt signaling, Wnt signaling in stem cells, tissue homeostasis and regeneration and Therapeutic targeting of Wnt signaling. Insights into the Wnt function will be gleaned from a broad spectrum of model organisms, including hydra, worms, flies, frogs, fish and mice. The diversity of scientists gathering at this meeting along with the broad spectrum of topics will not only provide a fertile learning environment that will certainly benefit all attendees, but will also lead to new insights, interactions and future collaborations that will push the boundaries of biomedical research. The main long-term goal of this GRC is to raise our understanding of this complex and critical signaling pathway and thereby contribute to the continuous development of methods to target and manipulate this pathway for eventual therapeutic interventions of currently incurable diseases.

项目摘要 我们要求对戈登研究会议（GRC）和戈登研究研讨会（GRS）的部分支持 标题为“ Wnt信号传导：分子机制，发育和Ttissue稳态和治疗学”为 2021年8月1日至6日在西班牙卡斯特尔德费尔斯的Rey Don Jaime Grand Hotel举行。这次会议将主持 由斯蒂芬·安吉斯（Stephane Angers）（加拿大多伦多大学）和玛丽安·比恩兹（MRC，英国）与肯·卡迪根（Ken Cadigan） （美国密歇根大学）和玛德隆·莫里斯（Madelon Maurice）（荷兰UMC UTRECHT）作为Vice-Chairs。 许多著名科学家的演讲，在各种职业阶段，都活跃于WNT生物学领域。这 GRS将于2021年7月31日至8月1日在同一地点举行，并将举办毕业生的演讲 学生和博士后研究员将由博士后研究员罗尼·奇迪亚克（Rony Chidiac）（多伦多大学）领导 和Pooja R. Sonavane（USCD）。会议的具体目的是为演讲提供论坛 并讨论WNT生物学各个方面的最新进展和新思想。该领域的进度有 一贯加速，并在所有后生生命形式中都涉及无数的生物学过程。在 此外，Wnt途径被广泛认为是组织稳态的关键调节剂，因此， 它的下调与许多疾病有关，从早期发育异常到与年龄有关 疾病，例如癌症。 会话主题是基于其对关键当前科学问题的潜在影响 在发育，干细胞生物学和癌症中。会议的结构是包括有关机制的会议 Wnt信号传递，Wnt信号的结构和功能，组织工程中的Wnt信号传导和 器官，疾病中的WNT信号，发育中的Wnt信号传导，bcatenin独立的Wnt信号，Wnt 干细胞中的信号传导，组织稳态以及Wnt信号的再生和治疗靶向。见解 进入Wnt函数将从广泛的模型生物中收集，包括水力，蠕虫，苍蝇， 青蛙，鱼和老鼠。在这次会议上聚集的科学家的多样性以及广泛的主题 不仅会提供肥沃的学习环境，肯定会受益于所有与会者，还将导致 新的见解，互动和未来的合作将推动生物医学研究的界限。 该GRC的主要长期目标是提高我们对这一复杂和关键信号途径的理解 从而有助于持续开发目标和操纵这一途径的方法 最终对目前无法治愈的疾病进行治疗干预措施。