Impact of Vitamin D on the Chemopreventive Efficacy of Erlotinib against Oral Cancer

维生素 D 对厄洛替尼口腔癌化学预防效果的影响

• 批准号: 10215646
• 负责人: Mukund Seshadri
• 金额: $ 25.23万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-16 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215646
• 关键词: Aerosols; Affect; Blood; COVID-19; COVID-19 pandemic; Cancer Patient; Chemopreventive Agent; Clinical; Dental; Dental Care; Dental Care Delivery; Dentistry; Diagnostic; Disease Outbreaks; Erlotinib; Exposure to; Funding; Grant; Health Professional; Healthcare; Medicine; Modification; National Institute of Dental and Craniofacial Research; Oral health; Persons; Procedures; Research; Saliva; Service delivery model; United States National Institutes of Health; Vitamin D; high risk; malignant mouth neoplasm; medical specialties; oral care; pandemic disease; patient population; respiratory; response; virtual

Project Summary The outbreak of COVID-19 has changed the practice of medicine in a fundamental manner resulting in sweeping changes in healthcare virtually across all medical specialties. Dentistry, in particular, has been dramatically affected by this pandemic, given the close `person-to-person' contact involved in delivering dental care and treatment procedures that produce aerosols and often result in the dental health care professional (DHCP) contact/exposure to blood, saliva and respiratory droplets. Specifically, the pandemic has led to adaptations to diagnostic and treatment paradigms, modifications to clinical workflow and dental/oral care delivery models. Given that the pandemic is still on-going, the magnitude of the impact of these modified oral health care delivery models, especially in high-risk patient populations (e.g. cancer patients) is not known. This application for a “Urgent Competitive Revision to Existing NIH Grants (Urgent Supplement)” is being submitted in response to PA-18-935 to request supplemental funding to the R01DE024595 (PI: Seshadri, Mukund). The research proposed in this supplement was specifically developed in response to the recent coronavirus disease 2019 (COVID-19) pandemic to assess the impact of dental care delivery delays in cancer patients. The proposal is of immediate and high impact to NIDCR.

项目摘要 Covid-19的爆发以基本方式改变了医学实践，导致 实际上，所有医学专业的医疗保健变化。尤其是牙科 鉴于交付牙齿的亲密“人与人与人的联系），受此大流行的影响很大 产生气溶胶并经常导致牙科医疗保健专业人员的护理和治疗程序 （DHCP）接触/暴露于血液，唾液和呼吸液滴。具体而言，大流行已导致 适应诊断和治疗范例，修改临床工作流程以及牙科/口腔护理 交付模型。鉴于大流行仍在进行中，因此这些改良的口服影响 尚不清楚医疗保健分娩模型，尤其是在高危患者人群（例如癌症患者）中。这 正在提交“对现有NIH赠款的紧急竞争修订（紧急补充）的申请” 为了回应PA-18-935，向R01DE024595（PI：Seshadri，Mukund）索取补充资金。这 该补充剂提出的研究是针对最近的冠状病毒的响应的。 2019年疾病（COVID-19）大流行，以评估牙齿护理延迟在癌症患者中的影响。 该提案对NIDCR有直接和高影响。