Acquisition of a 7T MR scanner for Translational Imaging Research at Roswell Park

购买一台 7T MR 扫描仪用于罗斯威尔公园的转化成像研究

• 批准号: 10176803
• 负责人: Mukund Seshadri
• 金额: $ 200万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176803
• 关键词: 20 year old; Aging; Applications Grants; Buffaloes; Comprehensive Cancer Center; Custom; Electronics; Faculty; Failure; Fee-for-Service Plans; Functional Imaging; Funding; Growth; Image; Imaging technology; Institution; Investigation; Magnetic Resonance Imaging; New York; Oncology; Radiology Specialty; Research; Research Personnel; Resource Sharing; Risk; S10 grant; Secure; Services; United States National Institutes of Health; Universities; anatomic imaging; cancer imaging; faculty research; instrument; member; molecular imaging; pre-clinical research; preclinical imaging; prevent; programs

Project Summary The purpose of this S10 grant application is to secure funding to replace a technically outdated 4.7T magnetic resonance imaging (MRI) scanner for the Translational Imaging Shared Resource (TISR) at Roswell Park Comprehensive Cancer Center. For nearly two decades, the TISR at Roswell Park has been providing customized scientific and technical preclinical imaging services on a fee for service basis to NIH funded investigators at Roswell Park, the State University of New York at Buffalo and neighboring academic institutions in Western New York. It is a heavily utilized by over 50 Roswell Park and UB faculty members who are conducting basic and translational investigations in oncology and radiology. The existing 4.7T magnet was purchased through a combination of institutional and state funds and was the first MR scanner installed in WNY dedicated for preclinical research. Since 2001, TISR has catered to the imaging needs of 168 users, out of whom 105 utilized the existing 4.7T MR scanner. However, this aging instrument has encountered two soft quenches in the last 10 years, and has outdated electronics that lack upgrading capabilities. These limitations pose a significant risk to faculty and research programs at the only NCI designated Comprehensive Cancer Center in the state of New York outside of Manhattan. Another technical failure of the present ~20-year-old MR scanner would be catastrophic and seriously jeopardize the conduct of active NIH/NCI funded research at Roswell Park and prevent our faculty from pursuing new projects utilizing MRI for anatomic, functional and molecular imaging of cancer. Acquisition of an upgraded instrument is therefore a critical need that will not only enable TISR to meet the existing demand for this imaging technology but also facilitate further growth of TISR.

项目摘要 该S10赠款申请的目的是获得资金，以取代技术过时的4.7T磁性 Roswell Park的转化成像共享资源（TISR）共振成像（MRI）扫描仪 综合癌症中心。近二十年来，罗斯威尔公园（Roswell Park）的TISR一直在提供 自定义的科学和技术临床前成像服务以服务费用为NIH资助 罗斯威尔公园的调查人员，纽约州立大学布法罗和邻近学者 纽约西部的机构。这是一个由50多名罗斯威尔公园和UB教职员工使用的大量利用 正在进行肿瘤学和放射学的基本和转化研究。现有的4.7T磁铁是 通过机构和国家资金的组合购买，是第一个安装的MR Scanner 专门用于临床前研究。自2001年以来，TISR满足了168位用户的成像需求 其中105位利用现有的4.7T先生Scanner。但是，这种老化的仪器遇到了两个软 在过去的10年中，淬火已经过时，这些电子设备缺乏升级功能。这些限制 在唯一指定的综合癌症的NCI中，对教师和研究计划构成了重大风险 曼哈顿以外的纽约州中心。目前〜20岁的MR的另一个技术故障 扫描仪将是灾难性的，并严重危害主动NIH/NCI资助的研究的行为 罗斯威尔公园（Roswell Park），并防止我们的教师使用MRI进行解剖，功能和功能的新项目 癌症的分子成像。因此，获取升级的工具是至关重要的需求 使TISR能够满足对这项成像技术的现有需求，但也促进了TISR的进一步增长。