Dynamics and Health Consequences of Obesity between Infancy and Young Adulthood in the United States

美国婴儿期和青年期肥胖的动态和健康后果

• 批准号: 10216394
• 负责人: Solveig Argeseanu Cunningham
• 金额: $ 7.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-15 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216394
• 关键词: Address; Adolescence; Adolescent; Adolescent obesity; Adult; Affect; Age; Age of Onset; American; Birth; Body Weight Changes; Body Weight decreased; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Chronic; Chronic Disease; Data; Data Set; Data Sources; Diabetes Mellitus; Dimensions; Disease; Effectiveness; Ethnic Origin; Exposure to; Gastrointestinal Diseases; Growth; Health; Height; High Prevalence; Incidence; Individual; Life; Life Cycle Stages; Life Tables; Light; Link; Longevity; Longitudinal cohort; Measures; Mental Health; Metabolic Diseases; Methodology; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Participant; Pattern; Policies; Population; Population Dynamics; Poverty; Prevalence; Public Health; Quality of life; Race; Recording of previous events; Research; Role; Rural; Rural Population; Standardization; Techniques; Testing; Translating; United States; Weight; Weight Gain; Youth; base; cardiometabolism; cohort; diabetes risk; early onset; emerging adult; ethnic disparity; ethnic minority population; experience; health disparity; high risk; infancy; innovation; intervention effect; mortality; obesity in children; physical conditioning; prevent; programs; public health priorities; racial disparity; racial minority; simulation; social disadvantage; socioeconomic disadvantage; socioeconomic disparity; socioeconomics; urban disparity; urban residence; young adult

PROJECT SUMMARY RELEVANCE: About 1/3 of adults and 1/5 of children and adolescents in the U.S. are obese, with socially disadvantaged individuals being disproportionately affected. Rapid, excessive weight gain in early life often translates into persistent obesity, which may be in turn be associated with earlier onset of several health complications. Differences in obesity timing thus may be a vital way in which race-ethnic, socioeconomic and regional disparities in health widen over the life course. OBJECTIVES: Our study will measure the dynamics of weight status during childhood, adolescence, and young adulthood and link these dynamics with subsequent health outcomes. A key contribution of our study is the careful and judicious use of statistical techniques to combine existing high-quality national longitudinal cohorts into a synthetic cohort of over 90,0000, followed from birth to age 55, reflective of recent experiences. AIMS: 1) Estimate the overall and sub-population dynamics of obesity, including the age and timing of obesity onset, age-specific incidence, obesity duration and intensity, weight fluctuations, and cumulative exposure to unhealthy weight. 2) Calculate the sub-population cumulative exposure to high BMI during childhood, adolescence and young adulthood for contemporary U.S. cohorts. 3) Estimate individual associations between exposure to high BMI across the first decades of life and adult health, specifically diabetes, cardiovascular, metabolic, and gastrointestinal diseases and quality of life, to quantify the health effects of early-life obesity dynamics. 4) Estimate the contribution of disparities in obesity dynamics early in life to disparities in other health outcomes across race-ethnic, SES, and urbanicity groups. 5) Develop a simulation to model the effects of interventions to reduce childhood obesity on national burdens of adult disease and disparities in disease. DESIGN: We will integrate 7 datasets into a single nationally- representative synthetic cohort. We will use recently-tested approaches to model multiple dimensions of weight dynamics. We will estimate the average number of years spent obese, as well as a continuous measure of BMI-years. We will link an individual’s obesity history with health complications using additive, duration, peak BMI, and weight change models. We will evaluate obesity dynamics separately in underserved race-ethnic, SES, and rural populations and will use decomposition approaches to quantify the contributions of these dynamic to disparities in health conditions. We will develop a “macro-simulation” that allows us to assess the impact of reductions in obesity incidence at key points in childhood and adolescence on the national prevalence of obesity in adulthood, health complications in adulthood, and race, ethnic, socioeconomic and urbanicity disparities in obesity and other chronic conditions. SIGNIFICANCE: The creation of a synthetic national cohort addresses the critical absence of nationally representative data to track obesity from childhood into adulthood. Our research will provide the first comprehensive set of estimates of exposure to obesity during the first decades of life and their contribution to health and disparities in health over the lifespan.

项目摘要 相关性：美国约有1/3的成年人和1/5的儿童和青少年是肥胖的，有社会 不利的人经常会受到不足的影响。 转化为持续的柔软，这可能与早期健康的发作有关 并发症。 健康方面的区域差异扩大了。 在儿童期，青春期和年轻成年期间的体重状况，并将这些动态与随后 健康结果。 将现有的高质量国家纵向队列结合成90,0000多个合成队列 从出生到55岁，反映了最近的经验：1） 肥胖动力，包括和时机发作，特定年龄的发病率，肥胖持续时间和 强度，体重波动和累积暴露于不健康的体重。 在童年时期，青少年和年轻的成年期间，美国当代的累积暴露于高BMI 队列3）在生命的头几十年中，估计暴露于高BMI的个人关联 成人健康，特别是糖尿病，心血管，代谢和胃肠道扫描和生命。 量化早期肥胖动态的健康影响。 生命的早期，在种族族裔，SES和城市化群体中的其他健康成果的差异。 开发模拟以模拟国际的影响，以减少儿童罩肥胖对国家负担 成人疾病和疾病的差异：我们将将7个数据集整合到一个国家 我们将使用最近经过测试的方法来进行多种 体重动态。我们将估计平均数字肥胖 BMI年。 BMI和体重变化模型。 SES和农村人口，将分解方法 在健康状况下的动态差异。 儿童和青春期关键点肥胖发生率的减少对国家患病率的影响 成年期的善意，成年中的健康并发症以及种族，种族，社会经济和城市化 肥胖和其他慢性疾病的差异。 队列解决了迫切缺乏全国代表性数据，以跟踪从童年的观察到 成年。 生命的头几十年及其对健康和健康差异的贡献。