The AnVIL Data Ecosystem

AnVIL 数据生态系统

• 批准号: 10222996
• 负责人: Robert J Carroll
• 金额: $ 50万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222996
• 关键词: Adopted; Bioconductor; Data; Data Analyses; Data Set; Development; Ecosystem; Ensure; Future; Galaxy; Genome; Genomics; Goals; Ingestion; Link; Patients; Protocols documentation; Research Personnel; Support System; System; Technical Expertise; Time; Work; cost; data access; data ecosystem; data harmonization; data sharing; improved; interoperability; large scale data; symposium

Project Summary In working to achieve the long-term goal of the AnVIL of providing a unified platform for ingestion and organization for a multitude of current and future genomic and genome-related datasets, it is clear that enabling the cross-talk of multiple platforms and datasets is a critical barrier. To overcome this challenge, we propose to improve, adopt, and implement shared standards for DRS and RAS within the Terra platform. To do that, we propose the following aims and subaims: 1. Enhance cross-system interoperability through development and implementation of standards for authentication and for sharing data and applications 1.1 Interoperability standards and technical requirements: Improve interoperability standards, scope technical work needed to support these standards, and develop conventions across systems to facilitate the realization of these use cases 1.2 Terra DRS and RAS support:  Ensure GA4GH DRS 1.1 support. Data should be accessible over the protocol supporting the systems described in the interoperability use cases. DRS 1.1 is the latest version of the GA4GH standard and includes GUID support  Include RAS account linking and token management  Ensure PFB search handoff support improvements as the convention is refined  Ensure Leonardo accommodates DRS 1.1 and RAS support 1.3 Galaxy and R / Bioconductor DRS and RAS support:  Ensure GA4GH DRS 1.1 support in Galaxy and R / Bioconductor, so data can be accessed using that standard  Include RAS token sharing with Galaxy and RStudio instances in Terra, allowing Galaxy and R / Bioconductor to access DRS accessible data using RAS credentials 2. Complete the scoping required to integrate RAS support into the Data Use Oversight System (DUOS) 2.1 Complete scoping to add support to DUOS to enable data access committees to issue visas to researchers

项目概要 致力于实现 AnVIL 的长期目标，即提供统一的摄取和处理平台 组织大量当前和未来的基因组和基因组相关数据集，很明显 实现多个平台和数据集的串扰是克服这一挑战的关键障碍。 建议在 Terra 平台内改进、采用和实施 DRS 和 RAS 的共享标准。 为此，我们提出以下目标和分目标： 1. 通过制定和实施标准来增强跨系统互操作性 身份验证以及共享数据和应用程序 1.1 互操作标准和技术要求：完善互操作标准、范围 支持这些标准所需的技术工作，以及跨系统发展的公约 促进这些用例的实现 1.2 Terra DRS 和 RAS 支持：  确保 GA4GH DRS 1.1 支持可通过支持的协议访问数据。 互操作性用例中描述的系统是 DRS 1.1 的最新版本。 GA4GH 标准并包括 GUID 支持  包括 RAS 帐户链接和令牌管理  确保随着惯例的完善，PFB 搜索切换支持得到改进  确保 Leonardo 适应 DRS 1.1 和 RAS 支持 1.3 Galaxy 和 R/Bioconductor DRS 和 RAS 支持： 确保 Galaxy 和 R/Bioconductor 中支持 GA4GH DRS 1.1，以便可以访问数据 使用该标准  包括与 Terra 中的 Galaxy 和 RStudio 实例共享 RAS 令牌，从而允许 Galaxy 和 R/Bioconductor 使用 RAS 凭据访问 DRS 可访问的数据 2. 完成将 RAS 支持集成到数据使用监督系统 (DUOS) 所需的范围界定 2.1 完成范围界定，增加对 DUOS 的支持，使数据访问委员会能够向 研究人员