The AnVIL Data Ecosystem

AnVIL 数据生态系统

• 批准号: 10166400
• 负责人: Robert J Carroll
• 金额: $ 21.72万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166400
• 关键词: 2019-nCoV; Award; Biology; COVID-19; COVID-19 pandemic; Certification; Clinical; Communities; Consent; Data; Data Analyses; Data Reporting; Data Set; Development; Disease; Ensure; Environment; Ethics; Fostering; Funding; Generations; Genetic; Genetic Determinism; Genetic Research; Genome; Genomics; Genotype; Goals; Grant; Growth; Guidelines; Human Genetics; Individual; Infection; Ingestion; Intake; Knowledge; Lead; Learning; Libraries; Metadata; Methods; Mission; National Human Genome Research Institute; Outcome; Parents; Patients; Pharmaceutical Preparations; Phenotype; Predisposition; Preparation; Procedures; Process; Protocols documentation; Questionnaires; Reaction Time; Research; Research Design; Research Personnel; Resource Sharing; Risk; Role; Sampling; Severities; System; Technology; Time; United States; Work; data access; data dissemination; data ecosystem; data ingestion; data sharing; data standards; data warehouse; experience; improved; member; parent grant; response

PROJECT SUMMARY In response to the COVID-19 pandemic, the Host Genetics Initiative (HGI) has formed to generate, share, and analyze data to identify the underlying genetic determinants of the SARS-CoV-2 infection and disease, including the severity in symptomatic presentation and associated outcomes, as well as the development of hypotheses for drug repurposing. To achieve the aims of the consortium, the need for a mechanism to ingest data and make it broadly available for researchers arose. With the National Human Genome Research Institute’s commitment to the same goals, the AnVIL, which is predicated on providing a cloud environment for the analysis of large genomic and clinical datasets, became the eminent choice to serve as a data repository and analysis platform for the consortium. As the technology has been developed through the parent grant, the aims proposed for this grant allows the AnVIL to provide scalable support for the Host Genetics Initiative in their utilization of the AnVIL. The specific aims include: • Aim 1: Scale the data Ingest processes for genotypic, phenotypic, clinical report data and metadata to support the expected influx of data from the Host Genetics Initiative • Aim 2: Utilize the Data Use Oversight System (DUOS) to facilitate expeditious data governance and access requests • Aim 3: Dissemination of data for researchers via featured workspaces done in partnership with the Host Genetics Initiative • Aim 4: Provide support for new data generator and user communities Through the implementation of these aims over the course of one year, we will enable the data that is generated by the members of the Host Genetics Initiative to be broadly shared and analyzed with researchers inside and outside of the consortium, which will serve to contribute to the global knowledge of the biology of SARS-CoV-2 infection and disease.

项目摘要 为了响应Covid-19的大流行，宿主遗传学倡议（HGI）已形成，以生成，共享和 分析数据以识别SARS-COV-2感染和疾病的潜在遗传决定剂， 包括症状表现和相关结果的严重程度，以及 用于重新利用药物的假设。为了实现财团的目标，需要一种机制来摄取 数据并广泛用于研究人员。随着国家人类基因组研究 研究所对同一目标，砧座的承诺，该目标可以预测为提供云环境 大型基因组和临床数据集的分析已成为作为数据存储库的重要选择 和财团的分析平台。随着技术是通过父母赠款开发的 提出的该赠款的目的使砧能为宿主遗传学计划提供可扩展的支持 他们对砧的利用。具体目的包括： •目标1：扩展基因型，表型，临床报告数据和元数据的数据摄入过程 支持来自主机遗传学计划的数据的预期影响 •目标2：利用数据使用监督系统（DUOS）来促进迅速的数据治理和 访问请求 •AIM 3：通过与该研究人员合作完成的特色工作空间向研究人员传播数据 寄主遗传学计划 •AIM 4：为新数据生成器和用户社区提供支持 通过在一年的时间内实施这些目标，我们将启用数据 由主机遗传学计划成员生成的，与研究人员进行广泛共享和分析 财团内外，这将有助于全球生物学知识 SARS-COV-2感染和疾病。