The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) Cohort

肥胖、生长、环境和社会压力（PROGRESS）队列的规划研究

基本信息

批准号：
10203965
负责人：
Maria Jose Rosa
金额：
$ 34.11万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2024-03-25
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10203965
关键词：
7 year old Address Adolescence Affect Age Air Pollution Back Behavioral Big Data Biological Biological Assay Biological Markers Biological Models Biometry Birth Chemical Exposure Chemicals Child Child Development Child Health Childhood Cities Cognitive Collaborations Complex Conceptions Data Data Collection Data Discovery Data Linkages Data Set Dental Development Disease Dose Educational Materials Enrollment Environment Environmental Exposure Environmental Health Epidemiologist Exposure to Family Fostering Funding Future Genetic Genomics Geographic Information Systems Goals Grant Green space Growth Health Human Incubators Infant Infrastructure Institutes Institutional Review Boards International Investments Laboratories Learning Disabilities Life Life Cycle Stages Link Longevity Maintenance Measurable Measures Methodology Methods Mexico Mission Modeling Monoclonal Antibody R24 Mothers National Institute of Environmental Health Sciences Nature Neurocognitive Neurologic Nutritional Obesity Outcome Participant Pathway interactions Perinatal Phenotype Positioning Attribute Predisposition Pregnancy Process Protocols documentation Psychologist Puberty Public Health Research Research Personnel Resources Sample Size Science Scientist Societies Statistical Data Interpretation Statistical Methods Stress Temperature Testing Time Tooth structure United States National Institutes of Health Universities Work base big-data science biobank built environment cognitive testing cohort data harmonization design early adolescence environmental chemical experience fetal follow-up gene environment interaction health data improved innovation molecular marker neurobehavior neurodevelopment next generation novel nutrition participant retention pediatrician phenotypic data postnatal prenatal prenatal exposure programs prospective protocol development remote sensing response social social factors social media social stress stressor success trend walkability web site

项目摘要

PROJECT SUMMARY/ABSTRACT Mount Sinai will partner with the National Institute of Public Health, Mexico and Columbia University to continue to follow 700 children at ages 8-11 in the PROGRESS birth cohort established in 2006 in Mexico City to study perinatal programming of child development. PROGRESS is a state of the art birth cohort that has developed innovative new methods to estimate past exposure to environmental chemicals, both with biomarkers of internal dose (e.g. teeth based chemical assays) and with geospatial modeling of the external environment via remote sensing(e.g. air pollution, green space etc). This application will also leverage Mount Sinai's recently established Environmental Health Sciences Laboratory to build upon our internationally recognized research expertise in children's environmental health. Our mission is to measure environmental exposures across pregnancy and childhood to determine how these factors affect neurodevelopment and growth. We are especially excited to extend this work in PROGRESS as our overarching goal is to prepare the cohort the coming era of exposomic research. In this R24 we will test methods for data harmonization that will be critical to future work. By piloting pooling methods with researchers with similarly designed cohorts we set the stage to build new consortia to study the health impacts of chemicals, nutrition, social factors, and the gene-environment interactions that underlie childhood disease. Our team has all the requisite expertise in exposure science, biostatistics, child health phenotyping and in cohort management. We have already developed several new methodologies to objectively reconstruct past chemical exposures that precisely estimate exposure timing, allowing researchers to identify susceptibility windows as they relate to child health. Over the last 10 years, PROGRESS has supported 16 NIH grants led by 10 different researchers (including 7 K awardees), demonstrating our ability to serve as an incubator for the next generation of Environmental Health scientists. To accommodate divergent research needs among this group, the PI has formed the equivalent of an Administrative Core that will plan, organize, streamline and prioritize field work by coordinating the associated administrative work (IRB, protocol development, finances etc). We will also develop new programs to assess participant needs in order to improve retention, adapt to advances in social media, assess new health outcomes and exposures, and implement new exposure/response assays as we prepare our cohort for future big data consortia research. This proposal links highly experienced environmental health scientists with statisticians, social epidemiologists, child psychologists, chemists, pediatricians, and epigeneticists to support the infrastructure of a highly functional, state of the longitudinal birth cohort that objectively measures the human environments that program child health. We will follow PROGRESS children up to the onset of puberty, linking fetal exposures to health changes inherent to this critical life stage. Finally, despite our many successes, without this R24, field work will cease and this application is critical to our future success.

项目概要/摘要西奈山将与墨西哥国家公共卫生研究所和哥伦比亚大学合作，继续追踪 2006 年在墨西哥城建立的 PROGRESS 出生队列中的 700 名 8 至 11 岁儿童研究儿童发展的围产期规划。 PROGRESS 是一个最先进的出生队列，开发了创新的新方法来估计过去对环境化学品的暴露，两者都具有内部剂量的生物标志物（例如基于牙齿的化学测定）和外部的地理空间模型通过遥感了解环境（例如空气污染、绿地等）。该应用程序还将利用 Mount 西奈半岛最近成立了环境健康科学实验室，以我们的国际化为基础儿童环境健康领域公认的研究专业知识。我们的使命是测量环境怀孕和儿童时期的暴露，以确定这些因素如何影响神经发育和生长。我们特别高兴能在 PROGRESS 中扩展这项工作，因为我们的首要目标是准备队列暴露研究的即将到来的时代。在此 R24 中，我们将测试数据协调方法，该方法将对未来的工作至关重要。通过与具有相似设计队列的研究人员一起试验汇集方法，我们设定了建立新联盟来研究化学品、营养、社会因素和环境对健康的影响的阶段儿童疾病的基因-环境相互作用。我们的团队拥有以下方面所有必要的专业知识暴露科学、生物统计学、儿童健康表型和队列管理。我们已经开发了几种新的方法来客观地重建过去的化学暴露，准确地估计暴露时间，使研究人员能够确定与儿童健康相关的易感性窗口。在过去 10 年中，PROGRESS 支持了由 10 名不同研究人员（包括 7 名研究人员）领导的 16 项 NIH 资助项目 K 获奖者），展示了我们作为下一代环境孵化器的能力健康科学家。为了满足该群体不同的研究需求，PI 成立了相当于一个行政核心，通过协调来规划、组织、简化和优先考虑现场工作相关的行政工作（IRB、协议开发、财务等）。我们还将开发新的评估参与者需求的计划，以提高保留率、适应社交媒体的进步、评估新的健康结果和暴露，并在我们准备队列时实施新的暴露/反应测定用于未来的大数据联盟研究。该提案将经验丰富的环境健康科学家联系起来与统计学家、社会流行病学家、儿童心理学家、化学家、儿科医生和表观遗传学家一起支持功能强大的基础设施，客观测量纵向出生队列的状态影响儿童健康的人文环境。我们将跟踪 PROGRESS 儿童直至开始青春期，将胎儿的暴露与这个关键生命阶段固有的健康变化联系起来。最后，尽管我们有很多如果没有 R24，现场工作将会停止，而该应用程序对于我们未来的成功至关重要。