Improving the Long-term Mechanical and Tribological Performances of Polymers for Total Joint Replacement Applications
改善全关节置换应用中聚合物的长期机械和摩擦学性能
基本信息
- 批准号:10204052
- 负责人:
- 金额:$ 6.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:BehaviorBiomedical ResearchBone ResorptionDataEnvironmentExposure toFractureGoalsHispanic-serving InstitutionHydrophobicityImplantInflammationInstitutionJoint ProsthesisJointsLiquid substanceLongevityLubricantsLubricationMechanicsMicroscopyMinority-Serving InstitutionModelingOperative Surgical ProceduresPerformancePolyethylenesPolymersPropertyProsthesisReplacement ArthroplastyResearchResearch Project GrantsResistanceStructureSurfaceTechniquesTexasTextureTimeTissuesTotal Hip ReplacementUnderrepresented StudentsUnited States National Institutes of HealthUniversitiesbone losscareerdensitydesignimplantable deviceimprovedirritationknee replacement arthroplastymechanical behaviormechanical propertiesnovelpolyetheretherketonesuccessultra-high molecular weight polyethylene
项目摘要
PROJECT SUMMARY
Joint replacement is one of the most demanding of all the implant applications in our body. The most
commonly used artificial joints are total hip replacement (THR) and total knee replacement (TKR), with over
285,000 THR surgeries performed every year in the USA. A variety of polymers, such as ultra high molecular
weight polyethylene (UHMWPE), polyetheretherketone (PEEK), and high density polyethylene (HDPE) have
been used for THR and TKR prostheses. Although there are many advantages, polymers may absorb liquid,
which becomes a major issue in the lubricated environment of the joints. The wetting of the polymer surface
due to lubrication can reduce the wear initially; however, in the long run, it may deteriorate the mechanical
properties and increase the wear rate significantly. The wear debris can incorporate into the surrounding
tissues, and can cause tissue irritation and inflammation, leading to bone resorption, bone loss, implant
loosening, and fracture of bone. The short lifespan of implants necessitates revision surgery, which is more
expensive, has lower success rates, and may induce additional tissue damage. Therefore, the long-term
mechanical and tribological behaviors of polymers under extended exposure to lubricated environment are
major concerns in TJR (total joint replacement) prostheses. The overarching goal of this project is to increase
the longevity of TJR prostheses, specifically THR and TKR, by improving the long-term mechanical and
tribological behaviors of polymers. It is hypothesized that increasing the hydrophobic properties of a polymer
can improve its long-term mechanical and tribological behaviors in a lubricated environment. To improve the
hydrophobic properties, micro-texture will be applied on the polymer surface. Surface texture can be formed as
micro-pit (cavity or dimple) or micro-pillar (protrusion). An array of dimples can improve the tribological
performance by acting as lubricant reservoirs; however, it can deteriorate the long-term mechanical and
tribological performances of a polymer due to wetting of the surface for an extended period of time. Protruding
micro-texture has shown to improve the hydrophobic properties of polymers significantly. However, such
surface textures are highly prone to wear and abrasion. The specific aims of the proposed project are to: 1)
establish relationship between surface texture and hydrophobic properties of polymers; 2) study the effect of
hydrophobicity on long-term mechanical behavior in various environmental conditions; 3) investigate the
relationship between surface texture and tribological performance of polymers under various lubricated
conditions; 4) analyze the contact mechanics of textured surfaces using numerical modeling; and 5) design
optimum surface texture for polymers to improve hydrophobicity, and long-term mechanical and tribological
performances in various lubricated environments. The proposed project will enhance the research capabilities
of the PI and his institution, Texas A&M University-Kingsville, which is a Hispanic serving institution. The
project will also encourage the underrepresented students to pursue career in the biomedical field.
项目摘要
关节置换是我们体内所有植入物应用中最苛刻的替代品之一。最多
常用的人造关节是总髋关节置换(THR)和总膝盖置换(TKR),
每年在美国进行285,000次THR手术。多种聚合物,例如超高分子
重量聚乙烯(UHMWPE),聚苯乙烯酮(PEEK)和高密度聚乙烯(HDPE)具有
用于THR和TKR假体。尽管有很多优点,但聚合物可能会吸收液体,
这成为关节润滑环境中的主要问题。聚合物表面的润湿
由于润滑,最初可以减少磨损。但是,从长远来看,它可能会恶化机械
性质并显着提高磨损率。磨损碎屑可以掺入周围
组织,并会引起组织刺激和炎症,导致骨吸收,骨质流失,植入物
松动和骨骼断裂。植入物的寿命短需要修改手术,这更多
昂贵,成功率较低,并可能导致额外的组织损伤。因此,长期
在扩展润滑环境下,聚合物的机械和摩擦学行为是
TJR(总置换)假体的主要关注点。该项目的总体目标是增加
通过改善长期机械和
聚合物的摩擦学行为。假设增加聚合物的疏水性能
可以在润滑环境中改善其长期的机械和摩擦学行为。改善
疏水性能,微文本将应用于聚合物表面。表面纹理可以形成
微坑(腔或凹坑)或微柱(突发)。一系列酒窝可以改善摩擦学
通过充当润滑剂储层的性能;但是,它可能会恶化长期的机械性和
由于表面润湿长时间,聚合物的摩擦学性能。突出
微观纹理已显示可显着改善聚合物的疏水性能。但是,这样
表面纹理非常容易磨损和磨损。拟议项目的具体目的是:1)
在聚合物的表面纹理与疏水性能之间建立关系; 2)研究
在各种环境条件下长期机械行为的疏水性; 3)调查
在各种润滑下,聚合物的表面纹理与摩擦学性能之间的关系
状况; 4)使用数值建模分析纹理表面的接触力学; 5)设计
聚合物改善疏水性以及长期机械和摩擦学的最佳表面纹理
在各种润滑环境中的性能。拟议的项目将增强研究能力
PI及其机构德克萨斯A&M大学 - 金斯维尔(Kingsville)是西班牙裔服务机构。这
项目还将鼓励代表性不足的学生从事生物医学领域的职业。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mohammad Motaher Hossain其他文献
Determination of Dichlorodiphenyltrichloroethane (DDT) and metabolites residues in Gangetic mystus (Mystus cavasius) and Spotted Snakehead (Channa punctatus) of Bangladesh
孟加拉国恒河鱼(Mystus cavasius)和斑鱼(Channa punctatus)中二氯二苯基三氯乙烷(DDT)及其代谢物残留量的测定
- DOI:
10.3329/bjz.v49i3.58513 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Mohammad Motaher Hossain;G. Latifa;Md Nashir Uddin Al Mahmud;Nilufar Nahar - 通讯作者:
Nilufar Nahar
Mohammad Motaher Hossain的其他文献
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{{ truncateString('Mohammad Motaher Hossain', 18)}}的其他基金
Improving the Long-term Mechanical and Tribological Performances of Polymers for Total Joint Replacement Applications
改善全关节置换应用中聚合物的长期机械和摩擦学性能
- 批准号:
10436205 - 财政年份:2020
- 资助金额:
$ 6.9万 - 项目类别:
Improving the Long-term Mechanical and Tribological Performances of Polymers for Total Joint Replacement Applications
改善全关节置换应用中聚合物的长期机械和摩擦学性能
- 批准号:
10656470 - 财政年份:2020
- 资助金额:
$ 6.9万 - 项目类别:
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