Diagnostic toxicology support for VetLIRN

VetLIRN 的诊断毒理学支持

• 批准号: 10197010
• 负责人: ROBERT HOWARD POPPENGA
• 金额: $ 2.78万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197010
• 关键词: Diagnostic; toxicology; support; VetLIRN

Project Summary/Abstract The objective of this proposal is to describe our laboratory's involvement in the FDA Veterinary Laboratory Information Response Network (VetLIRN). This proposal describes how we plan to provide analytical support for the toxicological analysis of animal tissues, feeds, foods, and other matrices of concern in the event that there is a chemical contamination incident that potentially compromises the safety of our nation's animal food supply or the health and safety of livestock, companion animals, or people. We propose to participate, as needed, in the development and expansion of analytical methods designed to screen a variety of matrices for diverse and potentially harmful chemicals, including unknown compounds, using GC/MS, LC/MS, ICP/MS, and other analytical methodologies. Laboratory personnel will participate in training exercises designed to assess the ability of VetLIRN to respond to surveillance, emergency response, and recovery scenarios, participate in national and regional meetings, and assist with the development and validation of methods for the analysis of chemical contaminants. Specific objectives include:  training of laboratory personnel in analytical toxicology methodologies needed by the VetLIRN  provision of analytical expertise to the improvement, expansion, and validation of existing VetLIRN toxicology methods  assistance with the development of new toxicology methods for the VetLIRN as needed  participation in VetLIRN proficiency testing programs  collaboration with other VetLIRN member laboratories to ensure the effectiveness of the VetLIRN program  participation in case investigations, animal feed surveillance, emergency response, or recovery exercises as the need arises  effectively communicating with other VetLIRN laboratories via the use of eLEXNET

项目概要/摘要 该提案的目的是描述我们实验室参与 FDA 的工作 兽医实验室信息响应网络（VetLIRN）。 描述了我们计划如何为毒理学分析提供分析支持 动物组织、饲料、食品和其他受关注的基质（如果存在） 可能危及国家安全的化学污染事件 动物食品供应或牲畜、伴侣动物或人的健康和安全。 我们建议根据需要参与分析的开发和扩展 旨在筛选各种基质中不同且潜在有害物质的方法 使用 GC/MS、LC/MS、ICP/MS 和其他技术分析化学品，包括未知化合物 实验室人员将参加培训练习。 旨在评估 VetLIRN 响应监测、紧急情况的能力 响应和恢复情景，参加国家和区域会议，并协助 随着化学分析方法的开发和验证 污染物。 具体目标包括：  对实验室人员进行分析毒理学方法方面的培训 兽医实验室  提供分析专业知识以改进、扩展和验证 现有的 VetLIRN 毒理学方法  协助 VetLIRN 开发新的毒理学方法 需要的 参与 VetLIRN 能力测试计划  与其他 VetLIRN 成员实验室合作，确保有效性 VetLIRN 计划  参与案件调查、动物饲料监测、紧急情况 根据需要进行反应或恢复练习  通过使用以下方式与其他 VetLIRN 实验室进行有效沟通 电子信息网