CAHFS Method Development and Validation; Discipline D Track 3; 7/1/2020-6/30/2021

CAHFS 方法开发和验证；

• 批准号: 10173540
• 负责人: ROBERT HOWARD POPPENGA
• 金额: $ 2.82万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10173540
• 关键词: CAHFS; Method; Development; Validation; Discipline

Discipline D Track 3: Method Development and Method Validation Project Summary The FDA’s utilization of chemical analysis is critical to the agency’s ability to protect the U.S. food supply from unsafe chemical contamination. There are continuing needs for new analytical methods and techniques to handle the challenges involved with new food matrices and to make effective use of new and more efficient analytical technology. The purpose of this project is to provide funding for preliminary investigations into new analytical approaches, method extensions to new food matrices, and multi-laboratory research studies. The Toxicology Section of the California Animal Health and Food Safety Laboratory (CAHFS) has extensive experience in method development and extension projects and evaluation of new technologies. The nature of veterinary analytical toxicology is such that there are constant requirements for new methods to be developed. Some of these methods are required to handle single events of toxicosis in animals while others are designed to become routine methods for long-term use. The ability to execute such development projects is integral to the Section’s mission of assuring the health of agricultural animals and the safety of their feeds in California. The Section maintains a variety of different types of instrumentation allowing for flexibility in analyte detection and the ability to analyze a wide variety of matrix types. CAHFS personnel are highly experienced in handling many types of method development projects. The section has worked collaboratively with the FDA to develop and validate a number of methods in the past and has had notable success in rapid method development in response to emergencies in the food supply. As part of this project, CAHFS has proposed a specific method development project for each of the five years covered by the grant. The methods proposed are intended to increase our ability to detect human food and animal feed contamination and prevent those commodities from injuring humans or animals. In summary, funding from this grant will allow CAHFS to continue to serve as a valued partner to the FDA in the exploration and development of new analytical chemistry methods and technologies.

学科 D 轨道 3：方法开发和方法验证 项目概要 FDA 对化学分析的利用对于该机构保护美国食品供应的能力至关重要 免受不安全的化学污染的影响，不断需要新的分析方法和方法。 应对新食品基质所涉及的挑战并有效利用新食品基质的技术 该项目的目的是为更有效的分析技术提供资金。 对新分析方法、新食品基质方法扩展的初步研究，以及 多实验室研究。 加州动物健康和食品安全实验室 (CAHFS) 毒理学科 在方法开发和推广项目以及新方法评估方面拥有丰富的经验 兽医分析毒理学的本质是有不断的要求。 需要开发新方法，其中一些方法需要处理单个事件。 动物中毒而其他方法被设计成为长期使用的常规方法。 执行此类发展项目是该科确保人民健康的使命的组成部分 加利福尼亚州的农业动物及其饲料的安全性。 该部门拥有各种不同类型的仪器，可灵活分析分析物 CAHFS 人员的检测和分析各种矩阵类型的能力非常高。 该部门在许多处理类型的方法开发项目方面经验丰富。 过去与 FDA 合作开发和验证了多种方法，并已取得 在应对食品供应紧急情况的快速方法开发方面取得了显著成功。 对于这个项目，CAHFS 提出了五年内每年一个具体的方法开发项目 所提出的方法旨在提高我们检测人类食物的能力。 和动物饲料污染，并防止这些商品伤害人类或动物。 总之，这笔赠款的资金将使 CAHFS 能够继续作为重要的合作伙伴 FDA致力于探索和开发新的分析化学方法和技术。