THE PRETERM BEHAVIORAL PHENOTYPE: TRAJECTORIES OF PSYCHOPATHOLOGY & CHANGES IN CEREBRAL CONNECTIVITY

早产行为表型：心理病理学的轨迹

基本信息

批准号：
10197781
负责人：
CYNTHIA Elise ROGERS
金额：
$ 58.78万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-21 至 2022-08-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197781
关键词：
Accounting Age Anisotropy Anxiety Attention Attention deficit hyperactivity disorder Behavior Behavioral Birth Brain Cerebrum Child Childhood Clinical Cohort Effect Collection Corpus Callosum Data Development Diagnosis Diffusion Magnetic Resonance Imaging Disease Early Intervention Emotional Evaluation Evolution Exhibits Exposure to Face Goals Growth Image Impairment Individual Intervention Investigation Link Longevity Longitudinal cohort Longitudinal cohort study Machine Learning Magnetic Resonance Imaging Maps Measures Mental Health Mental disorders Methodology Methods Modality Modeling Nature Neonatal Outcome Outcome Measure Pattern Perinatal Play Population Pregnancy Premature Infant Prevalence Process Psychopathology Public Health Quality of life Recording of previous events Research Personnel Risk Risk Factors Risk Marker Role Sampling Severities Standardization Structure Survival Rate Symptoms Techniques Time associated symptom autism spectrum disorder behavioral phenotyping clinically significant cohort comorbidity connectome design disorder risk early childhood early life exposure high risk imaging modality improved improved outcome inattention infancy innovation middle childhood neonatal magnetic resonance imaging neonate neurobiological mechanism neuroimaging novel strategies predictive modeling premature prospective psychiatric disability psychiatric symptom psychosocial sex social social communication social communication impairment sociodemographics targeted treatment temporal measurement white matter

项目摘要

PROJECT SUMMARY: Children born prematurely are at elevated risk for psychiatric disorders, including ADHD, autism and anxiety. Indeed, the ‘preterm behavioral phenotype’ is comprised of inattention, anxiety and social- communication impairments. This constellation of comorbid disorders persists across the lifespan, accounting for long-term impairment and diminished quality of life among very preterm (VPT; born ≤32 weeks gestation) children, a population at high risk for altered brain development. Yet, the neurobiological mechanisms underlying the increased prevalence of these symptoms remain undetermined. Further, VPT children face high exposure rates to deleterious psychosocial risk factors which have similarly been linked to adverse psychiatric outcomes and changes in brain development. We posit that decreased connectivity and the resulting diminished developmental trajectories within and across key functional networks (e.g., default mode, frontoparietal control and cingulo-opercular networks) and related white matter tracts (e.g., cingulum, corpus callosum and uncinate) underlie comorbid preterm behavioral phenotype symptoms that persist or worsen at age 9-10. This process begins during infancy and extends to middle childhood, with psychosocial risk playing an important modifying role. Advances in MRI methodology now enable characterization of structural and functional brain networks with unparalleled spatial and temporal resolution. Here, we couple these highly innovative, state-of-the-art MRI techniques with detailed psychiatric assessments to study our unique, sociodemographically-diverse longitudinal cohort of VPT and term-born children (N=302) with high rates of psychosocial adversity now reaching age 9-10. The cohort has been followed since birth, including prospective collection of high-quality neonatal functional and structural connectivity MRI data and longitudinal assessments of preterm behavioral phenotype symptoms and psychosocial and familial factors at ages 2 and 5, with >80% cohort retention to date at both assessment waves. Continued evaluation of this enriched cohort provides an opportunity to determine: 1) trajectories of preterm behavioral phenotype symptoms to define early indicators of later impairment enabling targeted interventions, 2) relationships between neonatal and age 9-10 functional and structural connectivity and these deficits, and 3) the modifying role of psychosocial adversity. Application of cutting-edge MRI acquisition and analysis methods, including machine learning approaches, enables unprecedented characterization of the effects of VPT birth on connectivity in the developing brain. We will extend these methods to delineate relationships between imaging measures and preterm behavioral phenotype symptoms, improving understanding of modifiable effects of early life exposures and psychosocial risk on psychiatric outcomes. These data are critical for developing individual- level neuroimaging, behavioral and psychosocial presymptomatic predictive models for adverse mental health outcomes, measures necessary to inform and evaluate treatments applicable during sensitive developmental periods which mitigate risks of psychopathology associated with prematurity and psychosocial adversity.

项目摘要：早产儿患精神疾病的风险较高，包括多动症、事实上，“早产行为表型”包括注意力不集中、焦虑和社交。这种共病障碍在整个生命周期中持续存在，会计。针对极早产儿（VPT；出生≤妊娠 32 周）的长期损害和生活质量下降儿童是大脑发育改变的高风险人群，然而，其背后的神经生物学机制。此外，这些症状的患病率是否增加仍不确定，VPT 儿童面临着高风险暴露。有害社会心理危险因素的发生率，这些危险因素同样与不良精神病结果相关我们假设连接性下降，从而导致大脑发育的变化。关键功能网络内部和之间的发展轨迹（例如，默认模式、额顶控制和扣带盖网络）和相关的白质束（例如扣带回、胼胝体和钩突）是 9-10 岁时持续存在或恶化的共病早产行为表型症状的基础。从婴儿期开始一直延伸到童年中期，心理社会风险起着重要的调节作用 MRI 方法的进步现在可以表征大脑网络的结构和功能。在这里，我们将这些高度创新、最先进的 MRI 结合起来。技术与详细的精神病学评估来研究我们独特的、社会人口统计学多样化的纵向心理社会逆境发生率较高的 VPT 和足月出生儿童 (N=302) 队列现已达到 9-10 岁。该队列自出生以来一直受到跟踪，包括前瞻性收集高质量的新生儿功能和结构连接 MRI 数据和早产行为表型症状的纵向评估 2 岁和 5 岁的心理社会和家庭因素，迄今为止，两次评估波次的队列保留率均超过 80%。对这个丰富队列的持续评估提供了一个机会来确定：1）早产的轨迹行为表型症状来定义后期损伤的早期指标，从而实现有针对性的干预，2) 新生儿和 9-10 岁儿童的功能和结构连接与这些缺陷之间的关系，以及 3) 尖端 MRI 采集和分析方法的应用，包括机器学习方法，能够前所未有地表征 VPT 出生对我们将扩展这些方法来描绘成像之间的关系。措施和早产行为表型症状，提高对早期可改变影响的理解生活暴露和心理社会风险对精神疾病结果的影响至关重要。不良心理健康水平的神经影像学、行为和心理社会症状前预测模型结果、告知和评估敏感发育期间适用的治疗所需的措施减轻与早产和社会心理逆境相关的精神病理学风险的时期。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Trajectories of Maternal and Paternal Psychological Distress After Fetal Diagnosis of Moderate-Severe Congenital Heart Disease.

胎儿诊断为中重度先天性心脏病后母亲和父亲心理困扰的轨迹。

DOI：
10.1093/jpepsy/jsac067
发表时间：
2023
期刊：
Journal of pediatric psychology
影响因子：
3.6
作者：
Mangin-Heimos,KathrynS;Strube,Michael;Taylor,Kaylin;Galbraith,Kymberli;O'Brien,Erin;Rogers,Cynthia;Lee,CarolineK;Ortinau,Cynthia
通讯作者：
Ortinau,Cynthia

Editorial: Maternal Inflammation During Pregnancy: A Modifiable Pathway Toward Improving Offspring Socioemotional Outcomes in Childhood and Adolescence.

社论：怀孕期间的母体炎症：改善后代童年和青春期社会情感结果的可修改途径。

DOI：
10.1016/j.jaac.2023.06.013
发表时间：
2023
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Lean,RachelE
通讯作者：
Lean,RachelE

Brain growth in the NICU: critical periods of tissue-specific expansion.

DOI：
10.1038/pr.2018.4
发表时间：
2018-05
期刊：
Pediatric research
影响因子：
3.6
作者：
Matthews LG;Walsh BH;Knutsen C;Neil JJ;Smyser CD;Rogers CE;Inder TE
通讯作者：
Inder TE

Cortical Functional Connectivity Evident After Birth and Behavioral Inhibition at Age 2.

出生后明显的皮质功能连接和 2 岁时的行为抑制。

DOI：
10.1176/appi.ajp.2017.17010018
发表时间：
2018
期刊：
The American journal of psychiatry
影响因子：
0
作者：
Sylvester,ChadM;Smyser,ChristopherD;Smyser,Tara;Kenley,Jeanette;AckermanJr,JosephJ;Shimony,JoshuaS;Petersen,SteveE;Rogers,CynthiaE
通讯作者：
Rogers,CynthiaE

Neonatal brain injury and aberrant connectivity.