Trajectories of Cortico-Cerebellar Connectivity, Social Competence, and Internalizing Symptoms in Adolescents Born Very Preterm

早产青少年的皮质小脑连接、社交能力和内化症状的轨迹

基本信息

批准号：
10684255
负责人：
CYNTHIA Elise ROGERS
金额：
$ 75.87万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-21 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684255
关键词：
Adolescence Adolescent Adult Age Anisotropy Behavior Birth Brain Cerebellum Child Childhood Cohort Effect Collection Data Development Diffusion Magnetic Resonance Imaging Dimensions Disease Early Intervention Emotional Evaluation Evolution Executive Dysfunction Exhibits Functional Magnetic Resonance Imaging Functional disorder Goals Growth Impairment Individual Intervention Interview Investigation Knowledge Lead Link Longitudinal cohort Longitudinal cohort study MRI Scans Magnetic Resonance Imaging Measures Mediating Methodology Modeling Nature Neonatal Pattern Play Pregnancy Premature Birth Process Prospective cohort Psychopathology Public Health Reporting Rest Risk Risk Factors Role School-Age Population Shapes Social Adjustment Social Functioning Social Interaction Structure Symptoms Techniques Testing Variant aged autism spectrum disorder cohort critical period design early childhood emotional functioning executive function extreme prematurity high risk imaging modality improved improved outcome infancy informant innovation middle childhood multimodality neonatal period neurodevelopment neuroimaging non-genetic novel strategies peer peer victimization predictive modeling premature preventive intervention prospective psychiatric symptom psychosocial risk mitigation sex social social cognition social communication social deficits social skills sociodemographics stem temporal measurement white matter

项目摘要

PROJECT SUMMARY: Children born very preterm (VPT, <32 weeks’ gestation) are at increased risk for social competency impairments compared to their term-born peers, including social communication deficits and poorer quality peer relationships leading to peer victimization and social rejection. Further, internalizing disorders are 2- 3 times higher in VPT children, with symptoms evident in early childhood and lasting into adulthood. Critically, how social competence impairments evolve and persist into adolescence, and the extent that known risk factors associated with VPT birth, including psychosocial adversity and executive dysfunction, shape their trajectory to increase risk for internalizing disorders remains unknown. Additionally, the cerebellum is a key structure adversely impacted by VPT birth, and aberrant cerebellar development is now recognized as a major risk factor for social communication deficits. Altered cerebellar development, along with its functional interactions with the Frontoparietal and Default Mode Networks involved in socio-emotional function, may be a key mechanism linking VPT birth, social impairment, and internalizing disorders. We posit that individual-specific patterns of cortico- cerebellar connectivity and related white matter tract (i.e., cerebellar peduncle) development underlie the evolution of social competence deficits, and in turn, internalizing disorders that persist or worsen at age 14-15, a critical period when peer interactions become more sophisticated and central. This process begins during infancy and extends to adolescence, with psychosocial risk playing a pivotal modifying role. Advances in MRI methodology now enable characterization of structural and functional brain networks with unparalleled spatial and temporal resolution. We couple innovative MRI techniques with detailed social-interaction and psychiatric assessments in a unique, longitudinal cohort of VPT and term-born adolescents (N=302; 137 VPT and 165 term- born) with high rates of psychosocial adversity now aged 14-15 years. The cohort has been followed since birth, undergoing prospective high-quality neonatal and school-age structural and functional connectivity MRI scans and longitudinal assessments of social competence, socio-emotional functioning, and psychosocial and familial risk at ages 2, 5, and 9-10 years (>80% retention at all waves). Continued evaluation of this valuable cohort provides an unprecedented opportunity to determine: 1) trajectories of social competence and internalizing symptoms for better identification of adolescents at greatest risk for psychopathology and 2) how trajectories of cortico-cerebellar structural and functional connectivity underlie these deficits. State-of-the-art MRI acquisition and analyses will characterize the deleterious effects of VPT birth on cortico-cerebellar connectivity into adolescence. We will delineate links between cortico-cerebellar connectivity, social competence, and internalizing disorders to elucidate modifiable psychosocial exposures and improve individual-level neuroimaging, behavior, and psychosocial predictive models that inform the timing of preventative interventions during sensitive periods of brain and socio-emotional development to mitigate risk for internalizing disorders.

项目摘要：出生的儿童非常早产（VPT，<32周的妊娠）的社会风险增加与他们的学期同龄人相比，能力障碍（包括社会交流缺陷和较差）优质的同伴关系导致同伴胜利和社会拒绝。此外，内部疾病是2- VPT儿童的3倍，在幼儿期间有症状证据，持续到成年。批判性，社会能力障碍如何发展并持续到青少年，以及已知风险因素的程度与VPT出生有关，包括社会心理广告和执行功能障碍，将其轨迹塑造成增加内在疾病的风险仍然未知。此外，小脑是关键结构受VPT诞生的不利影响，现在被认为是主要危险因素用于社会交流缺陷。小脑发育改变了其与涉及社会情感功能的额叶和默认模式网络可能是链接的关键机制 VPT诞生，社会障碍和内部疾病。我们肯定了皮质的个体特异性模式小脑连通性和相关的白质道（即小脑花梗）的发展是社会能力缺陷的演变，反过同伴互动变得更加复杂和中心的关键时期。这个过程开始于婴儿期并扩展到青少年，心理社会风险扮演着关键的修改角色。 MRI的进步方法论现在可以通过无与伦比的空间来表征结构和功能性脑网络和临时分辨率。我们将创新的MRI技术与详细的社交互动和精神病学结合在独特的VPT和期限出生的青少年的独特，纵向队列中的评估（n = 302; 137 vpt和165个学期 - 出生）现在有14-15岁的社会心理逆境率很高。自出生以来一直在跟随该队列，经过前瞻性高质量的新生儿和学龄结构和功能连通性MRI扫描以及对社会能力，社会情感功能以及社会心理和家庭的纵向评估 2、5和9-10岁的风险（在所有波浪中保留率> 80％）。继续评估这个有价值的队列提供了一个前所未有的机会来确定：1）社会能力的轨迹和内在化更好地识别患有心理病理风险最大的青少年的症状以及2） Cortico-Cerebellar结构和功能连通性是这些缺陷的基础。最先进的MRI获取分析将表征VPT诞生对Cortico-Cerebellar连接到中的删除影响青少年。我们将描述Cortico-Cerebellar连接性，社会能力和内部化疾病以阐明可改变的社会心理暴露并改善个人级别神经影像学，行为和社会心理预测模型，这些模型为预防干预的时间提供了信息在敏感的大脑和社会情感发展期间，以减轻内在疾病的风险。