Trajectories of Cortico-Cerebellar Connectivity, Social Competence, and Internalizing Symptoms in Adolescents Born Very Preterm

早产青少年的皮质小脑连接、社交能力和内化症状的轨迹

基本信息

批准号：
10684255
负责人：
CYNTHIA Elise ROGERS
金额：
$ 75.87万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-21 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684255
关键词：
Adolescence Adolescent Adult Age Anisotropy Behavior Birth Brain Cerebellum Child Childhood Cohort Effect Collection Data Development Diffusion Magnetic Resonance Imaging Dimensions Disease Early Intervention Emotional Evaluation Evolution Executive Dysfunction Exhibits Functional Magnetic Resonance Imaging Functional disorder Goals Growth Impairment Individual Intervention Interview Investigation Knowledge Lead Link Longitudinal cohort Longitudinal cohort study MRI Scans Magnetic Resonance Imaging Measures Mediating Methodology Modeling Nature Neonatal Pattern Play Pregnancy Premature Birth Process Prospective cohort Psychopathology Public Health Reporting Rest Risk Risk Factors Role School-Age Population Shapes Social Adjustment Social Functioning Social Interaction Structure Symptoms Techniques Testing Variant aged autism spectrum disorder cohort critical period design early childhood emotional functioning executive function extreme prematurity high risk imaging modality improved improved outcome infancy informant innovation middle childhood multimodality neonatal period neurodevelopment neuroimaging non-genetic novel strategies peer peer victimization predictive modeling premature preventive intervention prospective psychiatric symptom psychosocial risk mitigation sex social social cognition social communication social deficits social skills sociodemographics stem temporal measurement white matter

项目摘要

PROJECT SUMMARY: Children born very preterm (VPT, <32 weeks’ gestation) are at increased risk for social competency impairments compared to their term-born peers, including social communication deficits and poorer quality peer relationships leading to peer victimization and social rejection. Further, internalizing disorders are 2- 3 times higher in VPT children, with symptoms evident in early childhood and lasting into adulthood. Critically, how social competence impairments evolve and persist into adolescence, and the extent that known risk factors associated with VPT birth, including psychosocial adversity and executive dysfunction, shape their trajectory to increase risk for internalizing disorders remains unknown. Additionally, the cerebellum is a key structure adversely impacted by VPT birth, and aberrant cerebellar development is now recognized as a major risk factor for social communication deficits. Altered cerebellar development, along with its functional interactions with the Frontoparietal and Default Mode Networks involved in socio-emotional function, may be a key mechanism linking VPT birth, social impairment, and internalizing disorders. We posit that individual-specific patterns of cortico- cerebellar connectivity and related white matter tract (i.e., cerebellar peduncle) development underlie the evolution of social competence deficits, and in turn, internalizing disorders that persist or worsen at age 14-15, a critical period when peer interactions become more sophisticated and central. This process begins during infancy and extends to adolescence, with psychosocial risk playing a pivotal modifying role. Advances in MRI methodology now enable characterization of structural and functional brain networks with unparalleled spatial and temporal resolution. We couple innovative MRI techniques with detailed social-interaction and psychiatric assessments in a unique, longitudinal cohort of VPT and term-born adolescents (N=302; 137 VPT and 165 term- born) with high rates of psychosocial adversity now aged 14-15 years. The cohort has been followed since birth, undergoing prospective high-quality neonatal and school-age structural and functional connectivity MRI scans and longitudinal assessments of social competence, socio-emotional functioning, and psychosocial and familial risk at ages 2, 5, and 9-10 years (>80% retention at all waves). Continued evaluation of this valuable cohort provides an unprecedented opportunity to determine: 1) trajectories of social competence and internalizing symptoms for better identification of adolescents at greatest risk for psychopathology and 2) how trajectories of cortico-cerebellar structural and functional connectivity underlie these deficits. State-of-the-art MRI acquisition and analyses will characterize the deleterious effects of VPT birth on cortico-cerebellar connectivity into adolescence. We will delineate links between cortico-cerebellar connectivity, social competence, and internalizing disorders to elucidate modifiable psychosocial exposures and improve individual-level neuroimaging, behavior, and psychosocial predictive models that inform the timing of preventative interventions during sensitive periods of brain and socio-emotional development to mitigate risk for internalizing disorders.

项目摘要：极早产儿（VPT，妊娠 <32 周）的社交风险增加与足月出生的同龄人相比，能力有缺陷，包括社交沟通缺陷和较差高质量的同伴关系会导致同伴受害和社会排斥。此外，内化障碍是2-。 VPT 儿童的发病率高出 3 倍，症状在儿童早期就很明显，而且严重地会持续到成年。社交能力障碍如何演变并持续到青春期，以及已知风险因素的程度与 VPT 出生相关的，包括社会心理逆境和执行功能障碍，塑造了他们的轨迹增加内化障碍的风险仍然未知。此外，小脑是一个关键结构。受 VPT 出生的不利影响，小脑发育异常现在被认为是一个主要危险因素改变小脑发育及其与大脑的功能相互作用。涉及社会情感功能的额顶网络和默认模式网络可能是联系的关键机制我们认为，VPT 的出生、社交障碍和内化障碍是个体特定的皮质模式。小脑连接和相关白质束（即小脑脚）发育是社交能力缺陷的演变，进而导致14-15岁时持续存在或恶化的内在障碍，同伴互动变得更加复杂和集中的关键时期。婴儿期一直延伸到青春期，心理社会风险在 MRI 的进展中发挥着关键的改变作用。现在，该方法能够以无与伦比的空间特征来表征大脑网络的结构和功能我们将创新的 MRI 技术与详细的社交互动和精神病学结合起来。对 VPT 和足月出生青少年的独特纵向队列进行评估（N = 302；137 名 VPT 和 165 名足月出生青少年）出生）现在 14-15 岁的心理社会逆境发生率很高，该群体自出生以来一直受到跟踪，接受前瞻性高质量新生儿和学龄结构和功能连接 MRI 扫描以及对社交能力、社会情感功能以及心理和家庭的纵向评估 2、5 岁和 9-10 岁的风险（所有批次的保留率均超过 80%）。提供了前所未有的机会来确定：1）社会能力和内化的轨迹症状，以便更好地识别最有精神病理学风险的青少年，以及 2）皮质小脑的结构和功能连接是这些缺陷的基础。分析将描述 VPT 出生对皮质小脑连接的有害影响我们将描述皮质小脑连接、社交能力和青春期之间的联系。内化障碍以阐明可改变的社会心理暴露并提高个人水平神经影像、行为和心理社会预测模型，可告知预防性干预的时机在大脑和社会情感发展的敏感时期，以减轻内化障碍的风险。