Mental Health Research Network III

心理健康研究网络三

• 批准号: 10197802
• 负责人: GREGORY E. SIMON
• 金额: $ 202.76万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197802
• 关键词: Address; Antipsychotic Agents; Clinical; Clinical Research; Collaborations; Communication; Complex; Development; Evaluation; Feeling suicidal; Fostering; Funding; Future; Glutamate Receptor; Goals; Health Services Research; Health system; Healthcare Systems; Hybrids; Informatics; Infrastructure; Integrated Health Care Systems; Investigation; Leadership; Learning; Libraries; Machine Learning; Mental Depression; Mental Health; Methodology; Methods; National Institute of Mental Health; Network Infrastructure; Network-based; Observational Study; Observational epidemiology; Occupational activity of managing finances; Organization administrative structures; Patients; Pharmaceutical Preparations; Pilot Projects; Policies; Population; Practice based research; Primary Health Care; Process; Public Health; Public Health Informatics; Qualitative Research; Reaction Time; Recording of previous events; Request for Applications; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resource Informatics; Resources; Site; Software Tools; Speed; Strategic Planning; Suicide prevention; Testing; Time; Trust; Youth; analytical method; base; data infrastructure; disparity reduction; eHealth; effectiveness evaluation; effectiveness implementation design; first episode psychosis; health care delivery; implementation science; implementation study; improved; innovation; large scale data; member; next generation; open source; outreach; patient engagement; patient population; patient portal; perinatal intervention; peripartum depression; pilot trial; practice-based research network; pragmatic trial; programs; public health priorities; racial and ethnic disparities; response; risk prediction model; stakeholder perspectives; suicidal behavior; suicidal risk; treatment-resistant depression

Practice-based research has the potential to dramatically improve the speed, efficiency, relevance, and impact of mental health clinical and services research. Realizing those gains will require a practice-based research network capable of anticipating and adapting to changes in mental health care delivery, including: • Research fully embedded in real-world practice • Alignment of research goals with priorities of patient and health system stakeholders • Large-scale data infrastructure available for rapid analysis • A culture of trust and transparency to facilitate collaborative learning and improvement We propose to expand the existing Mental Health Research Network (MHRN) to include 14 research centers embedded in health systems serving a combined population of over 25 million patients in 16 states. MHRN infrastructure will be enhanced to support a next-generation practice-based network, including: • Increased engagement of patients, health system leaders, and other stakeholders in network governance • An expanded public, open-source library of software tools and other technical resources • More formal processes for conducting feasibility pilot projects and rapid response to stakeholder queries • Expanded outreach to external stakeholders and research partners This Overall application requests support for an Administrative Core, a Methods core, and four research projects. The Administrative Core will support all network activities, including ongoing affiliated research projects, new research projects proposed in this application, and new projects developed during the coming funding cycle. An Organizational Unit will include executive leadership, governance, strategic planning, and responsibility for financial management and regulatory compliance. An Outreach and External Collaboration Unit will be responsible for stakeholder engagement and developing collaborations with new research partners. An Emerging Issues Unit will support timely responses to emerging scientific and public health questions. The Methods Core will support optimal use of existing methods across all network research and develop new methods to address high-priority public health questions. An Informatics Unit will maintain and improve network data infrastructure and disseminate network-developed informatics resources. A Scientific Analysis Unit will focus on improving the methodologic rigor of network projects and development of innovative analytic methods driven by stakeholder needs. These infrastructure resources will support two Signature research projects (a pragmatic trial of eHealth interventions for perinatal depression and a real-time evaluation of new medications to address suicide risk) and two Pilot research projects (an investigation of stakeholder perspectives on implementation of suicide risk prediction models and a pilot trial of outreach to reduce disparities in depression treatment initiation).

基于实践的研究有可能显着提高速度，效率，相关性和影响力 心理健康临床和服务研究。意识到这些收益将需要基于实践的研究 能够预期和适应精神卫生保健提供的变化的网络，包括： •研究完全嵌入现实世界实践中 •将研究目标与患者和卫生系统利益相关者的优先级保持一致 •可用于快速分析的大规模数据基础架构 •一种信任和透明的文化，以促进协作学习和改进 我们建议将现有的心理健康研究网络（MHRN）扩展到包括14个研究中心 嵌入卫生系统中，为16个州的2500万患者组合服务。 MHRN 基础架构将得到增强，以支持基于下一代实践的网络，包括： •增加患者，卫生系统领导者和其他利益相关者在网络治理中的参与度增加 •扩展的公共，开源的软件工具和其他技术资源库 •进行可行性试点项目的更多正式流程以及对利益相关者查询的快速响应 •扩大对外部利益相关者和研究合作伙伴的宣传 该总体应用程序请求支持管理核心，方法核心和四个研究 项目。行政核心将支持所有网络活动，包括正在进行的会员研究 项目，本申请中提出的新研究项目以及未来的新项目 资金周期。组织部门将包括执行领导，治理，战略规划以及 财务管理和监管合规的责任。外展和外部合作 部门将负责利益相关者参与并与新研究合作伙伴开发合作。 新兴问题部门将支持及时对新兴科学和公共卫生问题的回答。这 方法核心将支持所有网络研究中现有方法的最佳使用并开发新的方法 解决高优先公共卫生问题的方法。信息单元将维护和改进 网络数据基础架构和传播网络开发信息资源。科学分析 单位将着重于改善网络项目的方法论和创新分析的发展 利益相关者需求驱动的方法。这些基础设施资源将支持两项签名研究 项目（对围产期抑郁症的eHealth干预措施的务实试验和对新的实时评估 解决自杀风险的药物）和两个试点研究项目（利益相关者的投资 关于实施自杀风险预测模型的观点和宣传试验试验以减少 抑郁症治疗计划的差异）。