Glycans in Blood Homeostasis and Disease

血液稳态和疾病中的聚糖

基本信息

批准号：
10194580
负责人：
Nancy M. Dahms
金额：
$ 97.2万
依托单位：
VERSITI WISCONSIN, INC.
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10194580
关键词：
Address Adult Affect Applications Grants Area Basic Science Benign Biochemistry Biology Blood Blood Platelets Blood Vessels Childhood Clinical Communication Discipline Disease Environment Enzymes Faculty Fertilization Foundations Future Future Generations Generations Glycobiology Glycosaminoglycans Hematological Disease Hematology Hematopoiesis Hemostatic function Homeostasis Immunology Inflammation Investigation Language Leadership Lysosomal Storage Diseases Mainstreaming Medical Mentors Mentorship Mission National Heart, Lung, and Blood Institute Patient Care Pharmaceutical Chemistry Polysaccharides Positioning Attribute Program Development Publications Research Research Personnel Role SECTM1 gene Scientist Structure Systems Biology Thinking Thrombopoiesis Training United States National Institutes of Health Work career career development clinical translation improved member programs receptor binding response skill acquisition transfusion medicine translational medicine

项目摘要

PROJECT SUMMARY In response to the urgent need to “transform and democratize glycosciences from a super-specialized research domain into the mainstream of biology and clinical translation such that glycans become an integral component of future scholars'/investigators' scientific thinking”, we present a unique, multi-PI, multi-center K12 career development program referred to as Program for Medical GlycoSciences. This Program will address this need with one-on-one and team-mentorship approaches to enable emerging generations of researchers to acquire the strongest possible foundation in pursuing basic and applied glycobiology of relevance to hematologic disorders. The 23-member Program Faculty is comprised of 1) clinicians trained in benign hematology, transfusion medicine, immunology, and lysosomal storage diseases, and 2) basic scientists with diverse expertise in biochemistry of glycosaminoglycans (GAGs), glycan-binding receptors, glycan-modifying enzymes, medicinal chemistry, and systems biology. The Program Faculty will work together to generate a common “glyco-clinical” language that will allow cross-communication and fertilization between clinical and basic researchers to train future generations of glyco-clinical scientists. This Program will achieve this mission by seamlessly combining four major areas of investigation: 1) `Glycans In Hematopoiesis, Thrombopoiesis, Platelets, And Vascular Biology'; 2) `Lysosomal Enzyme Function', 3) `Glycans In Lineage Fate Decision And In End Effector Functions'; 4) GAGs In Hemostasis, Hematopoiesis And Inflammation'. The Specific Aims of this Program are: 1. To identify and train ten exceptionally qualified Scholars in glycochemistry/glycobiology within context of adult/pediatric benign hematology, transfusion medicine or in clinical disciplines relating to the mission of the NHLBI, in a structured, mentored and protected environment. Each Scholar will receive 2 – 3 years of glycoscience skills development that focuses on acquisition, interpretation and publication of research, enabling federal (NIH/NSF) grant applications for transition to an independent academic position. 2. To seamlessly integrate clinically trained Scholars into glycosciences and basic science Scholars into translational medicine to affect efficient transfer of emerging glyco-concepts from bench to improved patient care. 3. To provide a structured environment such that at the end of the program, the majority of K12 Scholars will be: a) initiated in an academic glycoscience career, and b) at the cusp of leadership roles in translational glycoscience preferentially in adult/pediatric benign hematology, transfusion medicine or in clinical disciplines relating to the mission of the NHLBI.

项目概要响应“将糖科学从超专业研究转变为民主化”的迫切需要领域进入生物学和临床转化的主流，使聚糖成为不可或缺的组成部分未来学者/研究者的科学思维”，我们呈现独特的、多PI、多中心的K12职业生涯称为医学糖科学计划的开发计划将解决这个问题。需要一对一和团队指导的方法，使新兴一代的研究人员能够为追求相关的基础和应用糖生物学奠定最坚实的基础项目教员由 23 名成员组成，其中 1) 接受过良性血液疾病方面的培训。血液学、输血医学、免疫学和溶酶体贮积病，以及 2) 基础科学家糖胺聚糖 (GAG)、聚糖结合受体、聚糖修饰生物化学方面的多种专业知识酶、药物化学和系统生物学。共同的“糖临床”语言将允许临床和临床之间的交叉交流和受精培养下一代糖临床科学家的基础研究人员将实现这一使命。通过无缝结合四个主要研究领域：1）“造血作用、血小板生成、 2) `溶酶体酶功能', 3) `谱系命运决定中的聚糖和在末端执行器功能中；4) GAG 在止血、造血和炎症中的具体目标。该计划是： 1. 在糖化学/糖生物学领域识别和培训十名特别合格的学者成人/儿童良性血液学、输血医学或与使命相关的临床学科 NHLBI，在一个结构化、受指导和受保护的环境中，每位学者将获得 2 - 3 年的学习机会。糖科学技能发展，重点是研究的获取、解释和出版，允许联邦（NIH/NSF）拨款申请过渡到独立学术职位。 2. 将受过临床训练的学者无缝融入糖科学领域，将基础科学学者无缝融入糖科学领域转化医学将新兴的糖概念从实验室有效转移到改进的病人护理。 3. 提供一个结构化的环境，以便在项目结束时，大多数 K12 学者将是：a）开始糖科学学术生涯，b）处于转化领域领导角色的巅峰糖科学优先于成人/儿童良性血液学、输血医学或临床与 NHLBI 使命相关的学科。