Non-Invasive Wideband Radiometer for Accurate Core Temperature Monitoring

用于精确监测核心温度的非侵入式宽带辐射计

基本信息

批准号：
10194492
负责人：
Asimina Kiourti
金额：
$ 7.21万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10194492
关键词：
Adult Adverse effects Affect Air Algorithms Anatomic Models Anatomy Anesthesia procedures Biological Biomimetics Body Temperature Changes Bolus Infusion Brain Cancer Diagnostics Cardiac Cardiac Surgery procedures Cerebrum Clinical Clinical Research Data Detection Development Devices Environment Equilibrium Esophagus Event Exhibits Family suidae Fatty acid glycerol esters Frequencies Future Goals Gold Hair Head Health Hospital Costs Human Ice Ice Cover Knowledge Link Malignant hyperpyrexia due to anesthesia Measurement Measures Medical Modeling Monitor Nasopharynx Operating Rooms Operative Surgical Procedures Outcome Patients Pediatrics Perioperative Postoperative Period Process Pulmonary artery structure Radiation Radiometry Reporting Research Scalp structure Skin Surface Surgical Blood Loss Surgical Wound Infection Techniques Temperature Thermometers Thick Time Tissue Model Tissues Transfusion Translating Validation Variant Water animal tissue base beef cost density design dielectric property expectation human subject innovation interest natural hypothermia non-invasive monitor novel novel marker radio frequency stroke patient transmission process

项目摘要

PROJECT SUMMARY / ABSTRACT Clinical studies indicate a great need for monitoring core temperature throughout the perioperative process at a desired accuracy of <0.5oC. Accurate and fast detection of core temperatures beyond the intended ranges can decrease the likelihood of adverse effects, the outcomes of which may range from increased hospitalization costs to patient fatalities (e.g., during malignant hyperthermia). Unfortunately, current means of measuring core temperature present a tradeoff between invasiveness and accuracy and suggest a need for exploring novel solutions. Gold standard esophageal, nasopharynx and pulmonary artery thermometers are invasive and not feasible for all surgeries nor pre-/post-operatively; skin surface thermometers do not reflect core temperature and are affected by the environment; zero-heat-flux thermometers are unsuitable for intense body temperature changes and do not work for deep hypothermia; and state-of-the-art radiometers are inaccurate by 1oC to 2oC at best, and, hence, clinically unacceptable. The goal of this research is to explore the feasibility of an alternative radiometry technique that leverages innovations in broadband measurements, forward modeling of layered tissues, and dry biomimetic antennas to enable non-invasive, accurate, and real-time core temperature monitoring. The hypothesis is that low and high frequencies will infer the temperature from across deep and near-surface tissues, respectively, and that their post-processing will provide accurate measures of core temperature (within 0.5oC), in real-time, and across any temperature range of interest, as validated upon head- emulating phantoms. This study is significant because it reveals previously nonexistent knowledge on wideband radiometer models/algorithms and antenna designs for non-invasive and accurate core temperature monitoring. This radiometer is envisioned to be a much needed addition to the operating room, across the perioperative process, and beyond (e.g., cancer diagnostics). The expectation is to eventually link the device to other non-invasive monitors (e.g., cerebral oximeters in cardiac anesthesia) towards the development of new markers for more reliable and timely detection of complications. In Aim 1, wideband radiometry models and antennas will be developed. The focus entails translating models that have been successfully implemented in the past for inferring the temperature of layered ice sheets into layered head media. Such models have never been used in the context of medical radiometry. Optimal frequency ranges will then be identified, and biomimetic antennas will be designed to accommodate this bandwidth while exhibiting unprecedented radiation efficiency. In Aim 2, our integrated radiometer will be validated upon head phantoms that accurately emulate biological temperature flow and dielectric properties. Biomimetic antennas will be fabricated, connected to radiometers, and used to validate: a) the brightness temperature spectrum obtained from modeling, and b) the hypothesized accuracy of 0.5oC in retrieving the core temperature. Feasibility of this wideband radiometer in tissue-emulating phantoms will form the basis of future studies on human subjects.

项目摘要 /摘要临床研究表明，在整个围手术期间，都需要监测核心温度所需的精度<0.5oC。准确，快速检测到预期范围以外的核心温度可以减少不良反应的可能性，其结果可能从住院增加范围患者死亡的费用（例如，在恶性高温期间）。不幸的是，当前测量核心的方法温度在侵入性和准确性之间取决于折衷，并提出需要探索新颖的必要性解决方案。黄金标准食道，鼻咽和肺动脉温度计是侵入性的，而不是可行的所有手术或术前/术后；皮肤表面温度计不反映核心温度并受环境的影响；零热量温度计不适合强烈的体温变化，不适合深度体温过低；和最新的辐射仪不准确1oC至2oC 因此，充其量在临床上是不可接受的。这项研究的目的是探索利用宽带测量的创新，前向建模的替代辐射技术分层组织和干燥的仿生天线，以实现非侵入性，准确和实时核心温度监视。假设是，低频和高频将从深处和分别近地表组织，其后处理将提供核心的准确度量温度（在0.5oc之内），实时以及在任何感兴趣的温度范围内，在头部验证模拟幻影。这项研究很重要，因为它揭示了以前对宽带辐射计模型/算法和天线设计，用于非侵入性和准确的核心温度监视。设想该辐射计是手术室急需的补充围手术期及以后的过程（例如癌症诊断）。期望最终将设备链接到其他非侵入性监测仪（例如心脏麻醉中的脑氧仪）用于开发新的标记物，以更可靠，及时检测并发症。在AIM 1中，宽带辐射指标模型和天线将开发。重点需要成功实施的翻译模型将分层冰盖温度推到层次介质中的过去。这样的型号从来没有用于医疗辐射测定法。然后将确定最佳频率范围，并仿生天线将旨在适应这种带宽，同时表现出前所未有的辐射效率。在AIM 2中，我们的集成辐射计将在精确模拟的头幻象上进行验证生物温度流和介电特性。仿生天线将被制造，连接到辐射仪，用于验证：a）从建模获得的亮度温度光谱，b）假设0.5oc在检索核心温度时的精度。该宽带辐射计的可行性组织发射幻象将构成对人类受试者的未来研究的基础。