Neural Mechanisms of Cannabinoid-Impaired Decision-Making in Emerging Adults

新兴成年人大麻素决策受损的神经机制

• 批准号: 10190873
• 负责人: Michael J Wesley
• 金额: $ 15.79万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10190873
• 关键词: Acute; Address; Anodes; Attenuated; Award; Behavior; Behavioral Mechanisms; Brain; Cannabinoids; Cannabis; Cathodes; Chemicals; Clinical; Clinical Pharmacology; Communication; Data; Decision Making; Development; Disease Management; Dorsal; Drug Use Disorder; Drug abuse; Drug usage; Environment; Faculty; Functional Magnetic Resonance Imaging; Funding; Genetic; Goals; Grant; Impairment; Individual; Individual Differences; Intervention; Intoxication; K-Series Research Career Programs; Kentucky; Knowledge; Lateral; Lesion; Link; Maps; Measures; Medial; Medical; Medicine; Membrane Potentials; Mental Depression; Mentors; Methodology; Methods; National Institute of Drug Abuse; Nature; Neurocognitive; Neurons; Neurosciences Research; Neurotransmitters; Perception; Pharmaceutical Preparations; Physicians; Physiological; Population; Predisposition; Prefrontal Cortex; Process; Public Health; Research; Research Personnel; Research Project Grants; Research Training; Rest; Risk; Role; Safety; Series; Short-Term Memory; Site; Statistical Data Interpretation; Substance abuse problem; Supervision; Task Performances; Techniques; Testing; Tetrahydrocannabinol; Tissues; Training; United States National Institutes of Health; Universities; Writing; base; career development; college; disorder prevention; emerging adult; emerging adulthood; endogenous cannabinoid system; experimental study; frontal lobe; improved; individual response; innovation; interest; marijuana use; marijuana use disorder; marijuana user; meetings; neuroimaging; neuromechanism; noninvasive brain stimulation; preclinical study; professor; programs; relating to nervous system; response; responsible research conduct; skills; social; success

PROJECT ABSTRACT This mentored career development award (K01) will enable Dr. Michael Wesley to achieve his long-term goal of becoming an independent investigator with a clinical neuroscience research program examining cannabis use disorder (CUD) in emerging adults, which is a current NIDA funding priority. Dr. Wesley is a new Assistant Professor in the University of Kentucky (UK) College of Medicine. The activities proposed in this award build on Dr. Wesley’s background expertise in neuroimaging and drug abuse research and will allow him to accomplish the following short-term objectives: Become an expert in (1) clinical pharmacology and (2) non-invasive brain stimulation research in an emerging adult population with CUD, and enhance/develop his (3) knowledge of the responsible conduct of research, (4) skills for scientific communication and grant writing, and (5) ability to manage an independent research program. UK has numerous faculty and projects focused on drug abuse research and is an ideal environment for Dr. Wesley to complete this award. Dr. Wesley has assembled a stellar mentoring team consisting of Dr. Josh Lile (Mentor), who has a successful NIH-funded clinical pharmacology research program at UK and Dr. Mark George (Co-Mentor), who pioneered the use of non-invasive brain stimulation for treating depression. In addition, Dr. Lumy Sawaki (Internal Preceptor) and Dr. Lon Hays (Study Physician) will provide local safety oversight and medical supervision, and Dr. Terry Lohrenz (External Preceptor) will provide guidance with advanced statistical analysis of neuroimaging data. Dr. Wesley will also engage in a series of formal classes, lab exchanges, and research seminars/meetings to assist him in accomplishing the objectives of this award. The proposed research project is based on the premise that cannabis impairs decision-making processes and these impairing effects contribute to an increased risk of developing CUD in emerging adults. This research will combine the acute administration of ∆9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, with high-definition transcranial direct current stimulation (HD-tDCS) and neuroimaging, using rigorous methods, to examine the role of prefrontal cortex regions of interest in cannabis-impaired decision-making in emerging adults. Aim 1 will test the hypotheses that raising intrinsic PFC activity (Exp. 1) will attenuate, whereas lowering activity (Exp.2) will enhance, the impairing effects of THC on measures of decision-making and associated neurocognitive processes in emerging adults. Aim 2 will test the hypothesis that brain activity and connectivity during baseline task performance is associated with the subsequent response to THC and HD-tDCS. This highly innovative project will improve our understanding of the mechanisms involved in cannabis-impaired decision-making, which will inform CUD management and address a growing public health concern.

项目摘要 这个指导的职业发展奖（K01）将启用博士。 通过检查临床神经科学研究计划，成为依赖性的不感染者的目标 新兴成年人的大麻使用障碍（CUD）是当前的NIDA资金优先。 肯塔基大学（英国）医学院的助理教授。 以卫斯理博士的神经影像学和毒品abug abug的背景专业知识为基础 要实现以下短期目标：成为实验和（2） 在患有CUD的新兴成年人口中，非侵入性大脑刺激研究，并增强/发展他的 （3）了解研究的反应行为，（4）科学交流和授予写作的技能， （5）管理独立研究计划的能力。 英国有众多的教职员工，专注于药物滥用研究和理想环境 Wesiley博士完成了这个奖项。 Lile（导师），他在英国拥有成功的NIH资助的临床药理学研究计划和Mark博士 乔治（Co-Contor），他开创了非侵入性脑刺激的使用 此外，Lumy Saki博士（内部受体）和Lon Hays博士（研究医师）将提供当地安全 监督和医疗监督，特里·洛伦兹（Terry Lohrenz）博士（外部预制人）将提供指导 神经影像数据的高级统计分析。 实验室交流和研究研讨会/会议，以帮助他实现目标。 支撑研究项目基于大麻损害决策过程的前提 这些损害的影响有助于增加新兴成年人的风险 研究将结合急性给药 大麻中的成分，具有高定义的经颅直接弯道（HD-TDC）和神经成像， 使用严格的方法，检查大麻障碍前额叶皮层区域的作用 AIM 1中的决策将测试提高内在PFC活动的假设（经验） 将衰减，而降低活动（EXP.2）将增强，THC对措施的侵入影响 新兴成年人的决策和相关的神经认知过程。 基线任务性能期间的大脑活动和联系与随后的 对HD-TDC的反应。 大麻障碍决策涉及的机制将为CUD管理和地址提供信息 越来越多的公共卫生问题。