Vanderbilt Vaccine and Treatment Evaluation Unit

范德比尔特疫苗和治疗评估单位

基本信息

批准号：
10195286
负责人：
Clarence Buddy Creech
金额：
$ 1250.99万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-14 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10195286
关键词：
Academic Medical Centers Adult Age Area Award Bacterial Infections Biological Biological Assay Child Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Communicable Diseases Conduct Clinical Trials Data Development Disease Education Elderly Emerging Communicable Diseases Enrollment Environment Evaluation Faculty Feasibility Studies Fellowship Fostering Funding Geography Goals Home environment Human Immune response Immunity Immunization Immunologist Individual Infant Infection Influenza Institution International Intervention Laboratories Laboratory Scientists Lead Leadership Licensure Longevity Malaria Malaria Vaccines Medical Medical center Mentors Mentorship Methods Modeling Mycoses Nurses Parasitic infection Pathogenesis Pennsylvania Pertussis Vaccine Peru Pharmaceutical Preparations Phase Physicians Pneumococcal vaccine Population Population Heterogeneity Positioning Attribute Pregnant Women Prevention Principal Investigator Procedures Process Protocols documentation Research Research Infrastructure Research Personnel Safety Scientist Sexually Transmitted Diseases Site Smallpox Vaccine Standardization Systems Biology Tissues Training United States National Institutes of Health Universities Vaccination Vaccine Research Vaccines Viral Virus Diseases Visit Washington Work antibiotic resistant infections base career career development clinical research site comorbidity design early phase clinical trial ethnic diversity experience immunogenicity influenza virus vaccine innovation named group next generation novel novel strategies novel therapeutics novel vaccines pandemic influenza pathogen recruit research study respiratory response tool vaccine trial vaccinology volunteer

项目摘要

ABSTRACT The goal of this UM1 proposal is to use the remarkable research infrastructure at Vanderbilt University Medical Center and collaborating sites (Washington University, University of Pittsburgh, and University of Pennsylvania) to conceptualize, design, implement, and analyze clinical research studies across a wide variety of pathogens, infectious diseases, and populations as a Vaccine and Treatment Evaluation Unit (VTEU). Vanderbilt University Medical Center was among the first VTEUs funded and has led pivotal studies of influenza, pertussis, pneumococcus, smallpox, and malaria vaccines. The Vanderbilt VTEU has a proven capacity to enroll healthy populations rapidly, including participating in two NIH- directed influenza pandemic responses since 2009, as well as expertise enrolling special populations such as pregnant women, infants and children, adults with underlying medical comorbidities, and the elderly. In the current application, we have expanded our ability to recruit across the lifespan and across multiple pathogens, including increased expertise in sexually transmitted infections, malaria, and novel approaches to conducting clinical trial visits in the home setting. The Vanderbilt VTEU has also led efforts to train the next generation of vaccinologists and clinical trial experts in infectious diseases, including the development of a vaccinology fellowship, participation of fellows and junior faculty in protocol teams and data safety committees, and encouraging concept development by junior faculty. The Vanderbilt VTEU is also committed to working collaboratively with the newly formed Infectious Diseases Leadership Group to articulate priorities for ID research.

抽象的该UM1提案的目的是使用范德比尔特大学的非凡研究基础设施医疗中心和合作地点（华盛顿大学，匹兹堡大学和大学宾夕法尼亚州的）概念化，设计，实施和分析跨A的临床研究各种各样的病原体，传染病和种群作为疫苗和治疗评估单位（VTEU）。范德比尔特大学医学中心是第一批资助的VTEU，并领导了流感，百日咳，肺炎球菌，天花和疟疾疫苗的关键研究。范德比尔特 VTEU具有迅速入学人群的可靠能力，包括参加两个NIH- 自2009年以来，有指导流感大流行的反应以及招募特殊人群的专业知识例如孕妇，婴儿和儿童，具有潜在医疗合并症的成年人，老年。在当前的应用程序中，我们扩大了整个生命周期的招聘能力，跨多种病原体，包括增加性传播感染的专业知识，疟疾和在家庭环境中进行临床试验的新颖方法。 Vanderbilt Vteu也有领导了培训下一代疫苗学家和传染病临床试验专家的努力，包括发展疫苗学奖学金，研究员的参与和初级教师协议团队和数据安全委员会，并鼓励初级教师的概念发展。 Vanderbilt VTEU还致力于与新形成的感染力合作疾病领导小组以阐明ID研究的优先事项。