Childrens flame retardant exposures measured by passive wristbands: Sex specific associations, social adversity, and socio-cognitive development

通过被动腕带测量儿童的阻燃剂暴露：性别特异性关联、社会逆境和社会认知发展

• 批准号: 10186746
• 负责人: Molly L Kile
• 金额: $ 66.19万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10186746
• 关键词: Address; Age; Animal Model; Anxiety Disorders; Attention; Attention deficit hyperactivity disorder; Attenuated; Behavior; Behavior Disorders; Behavioral; Buffers; Characteristics; Chemicals; Child; Child Behavior; Child Development; Child Health; Cognitive; Data; Depressive disorder; Development; Developmental Disabilities; Disease; Emotions; Environmental Risk Factor; Ethnic Origin; Exposure to; Family; Flame Retardants; Goals; Health; Home; Human; Hyperactivity; Individual; Indoor environment; Informal Social Control; Interdisciplinary Study; Intervention; Knowledge; Measurement; Measures; Medical; Mental disorders; Neurocognitive; Nursery Schools; Organophosphates; Pesticides; Phase; Pilot Projects; Policies; Predictive Factor; Prevalence; Problem behavior; Production; Property; Public Health; Research; Risk; Risk Assessment; Risk Factors; Sampling; Schools; Short-Term Memory; Silicones; Social Behavior; Social Functioning; Societies; Standardization; System; Testing; Time; Toxicology; United States; aged; base; behavioral outcome; bullying; cognitive development; cognitive skill; cohort; environmental chemical; executive function; expectation; experience; externalizing behavior; first grade; flexibility; follow-up; health care service; human data; improved; inattention; individual variation; multidisciplinary; neurocognitive disorder; neurodevelopment; neurotoxic; polybrominated diphenyl ether; public health intervention; public health priorities; recruit; response; severe mental illness; sex; sex risk; skills; social; social deficits; social skills; social stressor

Project Summary/Abstract Children living in the United States are frequently exposed to polybrominated diphenyl ethers (BDEs) and organophosphate-based compounds (OPFRs) that are used as flame retardants in consumer goods. While the effects of BDE exposure on children’s neuro-cognitive and behavioral development has been studied, there is a lack of data on the developmental effects of OPFR exposure. Yet, toxicological data suggests that OPFRs may be more neurotoxic than BDEs. Animal models also show that social experiences have the potential to attenuate or buffer the effects of neurotoxic chemicals on neuro-cognitive and behavioral outcomes. Therefore, we propose a new interdisciplinary study that will improve our understanding of children’s exposures to flame retardant compounds, as well as, examine the interplay between flame retardants and adverse social experiences on children’s neuro-cognitive, executive functioning, and behavioral development. We propose to recruit 600 children aged 4-8 years as they enter preschool and follow them for 3 years until they graduate from first grade. The development that occurs during this time period is sizeable and corresponds with neural development associated with self-regulation of attention, emotion, and behavior. We will conduct repeated measurements during this follow up period to accomplish the following aims: (1) assess exposure to OPFRs and BDE among a diverse group of children to improve our understanding of factors that contribute to inter- and intra- individual variability, (2) examine the exposure-response relationship between OPFRs and children’s development between ages 4-8 years, and examine the potential for sex to modify these associations, and (3) examine the moderating influences of social stressors on the association between flame retardant exposures and children’s development. These aims all revolve around a central hypothesis that children with higher exposure to OPFRs and/or BDEs and will show lower neuro-cognitive, social, and behavioral skills. Completion of the proposed research is expected to provide new data on the human effects associated with flame retardant chemicals that are commonly found in the indoor environment. This data can be used to inform multi-pronged public health interventions that would ultimately improve children’s health and development.

项目摘要/摘要 居住在美国的儿童经常暴露于多溴二苯基醚（BDES）和 基于有机磷酸盐的化合物（OPFR），用作消费品中的阻燃剂。而 BDE暴露对儿童神经认知和行为发展的影响已经研究了，有一个 缺乏有关OPFR暴露的发展影响的数据。但是，毒理学数据表明OPFR可能是 比BDE更神经毒性。动物模型还表明，社会经历有可能减弱或 缓冲神经毒性化学物质对神经认知和行为结果的影响。因此，我们提出 一项新的跨学科研究，将提高我们对儿童阻燃的暴露的理解 化合物以及，检查阻燃剂与不利社会经历之间的相互作用 儿童的神经认知，执行功能和行为发展。我们建议招募600 他们进入学龄前儿童时，年龄4-8岁的儿童跟随他们3年，直到他们从一年级毕业。 在此期间发生的发展很大，与神经发育相对应 与注意力，情感和行为的自我调节有关。我们将进行重复测量 在此后续期间，以实现以下目的：（1）评估对OPFR和BDE的评估 一群潜水者群体，以提高我们对导致内部和内部因素的理解 个人变异性，（2）检查OPFR与儿童之间的暴露响应关系 在4-8岁之间发展，并检查性别改变这些关联的潜力，（3） 检查社会压力源对火焰阻燃暴露之间关联的调节影响 和儿童的发展。这些目的都是围绕一个中心假设，即患有更高的儿童 暴露于OPFR和/或BDE，并将显示出较低的神经认知，社会和行为技能。完成 预计拟议的研究将提供有关与火焰相关的人类影响的新数据 通常在室内环境中发现的化学物质。这些数据可用于通知多管齐 公共卫生干预措施最终将改善儿童的健康和发展。