ShEEP Request for Ultra-High-Frequency Ultrasound VisualSonics Imaging System

ShEEP 请求超高频超声 VisualSonics 成像系统

• 批准号: 10179602
• 负责人: Andrew Shoffstall
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179602
• 关键词: Amputation; Anatomy; Animal Experimentation; Animal Model; Animals; Applications Grants; Area; Blood Vessels; Blood flow; Brain; Budgets; Cardiac; Categories; Cerebrospinal fluid shunts procedure; Clinical; Clinical Research; Collaborations; Color; Computer software; Data; Device or Instrument Development; Devices; Dimensions; Electric Stimulation; Equipment; Evaluation; FPS-FES Oncogene; Frequencies; Funding; Future; Goals; Grant; Health; Image; Imaging Techniques; Implant; Individual; Institutional Review Boards; Intraoperative Monitoring; Investigational Therapies; Laboratories; Lead; Maintenance; Measurement; Medical Device; Medical center; Methods; Microelectrodes; Minor; Modeling; Monitor; Morphologic artifacts; Motion; Motor; Nerve; Nervous system structure; Neurologic; Noise; Operative Surgical Procedures; Pain; Paralysed; Parkinson Disease; Penetration; Performance; Peripheral Nervous System; Pharmacologic Substance; Physicians; Physiologic pulse; Prevalence; Price; Procedures; Prosthesis; Protocols documentation; Recording of previous events; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Resolution; Resource Sharing; Safety; Sensory; Sheep; Spinal cord injury; Stroke; System; Technology; Testing; Therapeutic; Therapeutic Intervention; Time; Tissues; Touch sensation; Transducers; Tremor; Ultrasonography; Vendor; Veterans; Work; animal facility; base; brain computer interface; chronic pain; clinical imaging; clinical implementation; cost; image guided; image processing; imaging capabilities; imaging system; improved; in vivo; in vivo imaging; in vivo monitoring; instrument; medical implant; migration; neural implant; neural prosthesis; neuroregulation; next generation; physically handicapped; portability; preclinical evaluation; prevent; price lists; programs; relating to nervous system; response

Neural interfaces used for electrical stimulation or recording of the nervous system have demonstrated and vast potential for rehabilitation of Veterans with various neurological or physical disabilities, ranging from motor neural prostheses, sensory neural prosthesis, and intracortical microelectrodes used for Brain-Computer Interfacing (BCI). Our research involves developing the next generation of neuromodulation therapies and neural prosthetic approaches to improve the lives of people with various neurological or physical disabilities, including spinal cord injury, stroke, amputation, or paralysis. The team’s research spans neural interface device development, preclinical evaluation of neural interfaces, and all the way to clinical implementation, involving safety and efficacy monitoring of neural interfaces. In all the team’s studies, there is a critical need to either A) better visualize the device-tissue interface, or B) quantitatively assess, in vivo, specific tissue health in response to therapies aimed at improving the device-tissue interface. In both cases, there is a need for a very high resolution live-imaging technique that is non-invasive so that it can be applied at multiple time points, longitudinally throughout a study. The requested Vevo 3100 LT is part of the FUJIFILM VisualSonics product portfolio which consists of the world’s first one-touch ultrasound platform that helps users visualize data at the highest resolution available (down to 30 µm, or 10x better than standard clinical ultrasounds). The system combines a number of features, such as HD image processing, to reduce speckle noise and artifacts, making it the ideal system for small animal and superficial clinical imaging (with approved IRB protocol). The wide range of probes (9-70 MHz) offers users the ability to select the ideal frequency and depth of imaging for each unique animal model and application. The lead PI, Dr. Shoffstall recently completed his CDA-1 and has established a new lab at the Cleveland VAMC with new Merit Review funding (anticipated start July 2020). He has multiple ongoing and future projects for which this equipment would be very valuable. Furthermore, he has assembled an array of investigators spanning those with multiple Merit Reviews as well as Junior level investigators, all whom have needs for the high frequency ultrasound technology to benefit their ongoing research goals. For the present grant application, the investigators have identified several areas of critical importance that would be aided by this equipment, specifically surrounding the evaluation of neural interfaces or associated treatments, including:  In vivo monitoring of experimental therapies  Surgical planning and neural interface implant monitoring  Intraoperative neural-fascicular anatomy studies  Ultrasound as therapeutic intervention / neuromodulation  (Secondary potential benefit); VA physician use in clinical cases (with approved IRB protocol) The investigators have a strong history of collaboration with one another, and collectively have many precedent examples that demonstrate resource sharing and maintenance of equipment. As the equipment carries a price of ~$150k, it would be challenging to justify its expense within a single Merit Review. The ShEEP is an ideal mechanism for the team to acquire the core equipment, defraying large upfront costs. Individual additional transducers cost ~$20k, and can be budgeted into future grants to meet specific study needs. The equipment will be housed within the APT Center laboratories and can be easily rolled between labs, including the animal facility. If funded, this equipment would greatly extend our Investigators’ imaging capabilities and improve the quality of multiple VA funded research programs.

已经证明了用于电刺激或记录神经系统的神经界面，并且已经证明了 康复的巨大潜力，具有各种神经或身体疾病的退伍军人 神经假体，感觉神经假体和用于脑部计算机的皮质内微电极 接口（BCI）。我们的研究涉及开发下一代神经调节疗法和神经元 假肢方法，以改善患有各种神经或身体疾病的人的生活，包括 脊髓损伤，中风，截肢或麻痹。该团队的研究跨越神经接口设备 开发，神经界面的临床前评估以及临床实施的所有方法 对神经界面的安全性和有效性监测。在所有团队的学习中，至关重要的是A） 更好地可视化设备组织界面，或b）定量评估，在体内，特定的组织健康响应 旨在改善设备组织接口的疗法。在这两种情况下，都需要很高 解决无创的现场模仿技术，以便在多个时间点应用它 在整个研究中纵向。 请求的VEVO 3100 LT是Fujifilm Visualsonics产品组合的一部分，该产品由 世界上第一个单触摸超声平台，可帮助用户以最高分辨率可视化数据 （降至30 µm，或比标准临床超声检查好10倍）。该系统结合了许多功能， 例如高清图像处理，以减少斑点噪声和人工制品，使其成为小动物的理想系统 和表面临床成像（具有批准的IRB方案）。广泛的探针（9-70 MHz）为用户提供 为每个独特的动物模型和应用选择理想频率和成像深度的能力。 铅PI，Shoffstall博士最近完成了CDA-1，并在克利夫兰建立了一个新的实验室 VAMC具有新的优异审查资金（预计于2020年7月开始）。他有多个正在进行的和未来的项目 对于此，该设备将非常有价值。此外，他已经组装了一系列调查员 跨越具有多个优点评论和初级调查人员的人，所有的人都需要 高频超声技术使其正在进行的研究目标受益。对于本授予申请， 调查人员已经确定了几个至关重要的领域，这些领域将由本设备提供帮助， 特别围绕着神经界面或相关治疗的评估，包括： 实验疗法的体内监测 手术计划和神经界面植入物监测 术中神经及时解剖学研究 超声为治疗干预 /神经调节 （二级潜在益处）； VA在临床情况下的物理用途（具有批准的IRB方案） 调查人员彼此之间有着悠久的合作历史，并且有很多 先例示例，证明了设备的资源共享和维护。作为设备 票价约为15万美元，在单个功绩审查中证明其费用是合理的挑战。绵羊 是该团队获得核心设备，支付大量前期成本的理想机制。个人 额外的换能器的成本约为20万美元，可以预算为未来的赠款以满足特定的研究需求。 设备将安置在公寓中心实验室内，并且可以在实验室之间轻松滚动，包括 动物设施。如果资助，此设备将大大扩展我们的调查人员的成像功能和 提高多个VA资助的研究计划的质量。