TIM Project NIDA P30 Center

TIM 项目 NIDA P30 中心

基本信息

批准号：
10177981
负责人：
Laura Maren Saba
金额：
$ 29.8万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10177981
关键词：
Archives Behavior Bioinformatics Biological Cells Code Collaborations Complex DNA DNA sequencing Data Data Set Databases Development Disease Drug Interactions Drug abuse Elements Environment Environmental Risk Factor Epigenetic Process Foundations Genes Genetic Genetic Transcription Genome Genomics Goals Human Hybrids Informatics Institution Instruction Letters Link Maps Measures Metadata Methods Modeling Molecular Multiomic Data Mus National Institute of Drug Abuse National Institute on Alcohol Abuse and Alcoholism Noise Participant Pathway interactions Pharmaceutical Preparations Pharmacotherapy Phenotype Prevention Process Protein Isoforms Proteins Publishing Quantitative Trait Loci RNA RNA Splicing Rattus Reproducibility Research Research Personnel Research Support Resources Risk Risk Factors Rodent Site Source Standardization Stress Sum System Systems Analysis Techniques Tissues Training Transcript Transcriptional Regulation Translations United States National Institutes of Health Untranslated RNA Variant Visualization addiction behavior influence brain cell data analysis pipeline data standards drug relapse genetic variant high throughput technology improved innovation neuronal circuitry novel precision medicine prevent programs protein metabolite ranpirnase sex single-cell RNA sequencing skills software systems tool transcriptome transcriptome sequencing transcriptomics web-based tool

项目摘要

Addiction is a highly complex disease with risk factors that include genetic variants and differences in development, sex, and environment. The long term potential of precision medicine to improve drug treatment and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers and clinicians from incorporating more powerful computational and predictive methods in addiction research. The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that influence drug abuse risk and treatment. The Administrative Core manages relations among research cores, groups of users, trainees, and pilot program participants. The Transcriptome Informatics and Mechanisms research core assembles and analyzes hundreds of large genome (DNA) and transcriptome (RNA) datasets for experimental rodent (rat) models of addiction. The Systems Analytics and Modeling research core is using innovative systems genetics methods to understand the linkage between DNA differences, environmental risks such as stress, and the differential risk of drug abuse and relapse. The Pilot core is catalyzing new collaborations among young investigator in the field of addiction research. In sum the Center is a national resource for more reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and integrating high quality data, metadata, using open software systems in collaboration with many other teams of researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research relevant to addiction research.

成瘾是一种高度复杂的疾病，危险因素包括遗传变异和差异发展，性别和环境。精确医学改善药物治疗的长期潜力预防取决于获得更好地了解遗传学，药物，脑细胞和神经元电路相互作用以影响行为。有严重的技术障碍可以阻止研究人员以及将更强大的计算和预测方法纳入成瘾研究中的临床医生。 NIDA P30 OMICS，系统遗传学和上瘾的核心核心核心核心中心的目的是为NIH，NIDA，NIAAA和其他联邦和州机构提供支持的研究人员的能力和培训使用更多定量和可检验的方法来分析遗传，表观遗传学和环境因素影响滥用药物的风险和治疗。行政核心管理研究核心之间的关系，一组用户，受训者和试点计划参与者。转录组信息学和机制研究核心组装并分析数百个大基因组（DNA）和转录组（RNA）数据集用于成瘾的实验啮齿动物（大鼠）模型。系统分析和建模研究核心正在使用创新的系统遗传学方法是了解DNA差异之间的联系，环境风险例如压力以及药物滥用和复发的差异风险。飞行员核心正在催化新的成瘾研究领域的年轻研究者之间的合作。总而言之用于成瘾中更多可再现研究的资源。我们正在集中，归档，分发，分析和集成高质量数据，元数据，使用开放软件系统与许多其他团队合作研究人员。我们的目标是帮助NIDA成瘾的门户网站，其中包括所有基因组研究与成瘾研究有关。