Overall NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome
总体而言,NIDA 转录组学、系统遗传学和成瘾组核心“卓越中心”
基本信息
- 批准号:10177978
- 负责人:
- 金额:$ 74.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:ArchivesBayesian ModelingBehaviorBehavioralBioinformaticsBiologyBiometryCellular AssayChromosome MappingCollaborationsCommunitiesComplexComputer softwareComputing MethodologiesConsultDNADNA SequenceDataData SetDatabasesDevelopmentDiseaseDrug InteractionsDrug abuseEducational workshopEnsureEnvironmentEnvironmental Risk FactorEpigenetic ProcessFoundationsFundingFutureGenesGeneticGenetic VariationGenomeGenomicsGenotypeGoalsHumanHybridsImageInformaticsInstitutionJointsLeadershipMachine LearningMetadataMethodsModelingMolecularNational Institute of Drug AbuseNational Institute on Alcohol Abuse and AlcoholismNeurosciences ResearchPharmaceutical PreparationsPharmacotherapyPopulationPreventionProteomePublicationsPublishingQuantitative GeneticsQuantitative Trait LociRNARattusRelapseReproducibilityResearchResearch PersonnelResourcesRiskRisk FactorsRodentRoleScientistSiteStandardizationStatistical ModelsStressSumSystemSystems AnalysisTestingTrainingTranslationsUnited States National Institutes of HealthUpdateVariantVisualizationWorkaddictionarchive dataarchived databasebehavior influencebrain cellcareercohortcomputerized toolscomputing resourcesdata handlingdata integrationdata modelingdata repositorydata toolsdeep learningdigital imagingdrug relapseepigenomeexperiencegenetic analysisgenetic variantgenomic variationgraphical user interfacehealth recordhigh dimensionalityimage archival systemimprovedinnovationinsightmetagenomemouse modelmultiple omicsneurogenomicsneuronal circuitrynovelprecision medicinepreventprogramsranpirnaserat genomesexsingle cell analysissoftware systemstooltranscriptometranscriptomicsweb portal
项目摘要
Addiction is a highly complex disease with risk factors that include genetic variants and differences in
development, sex, and environment. The long term potential of precision medicine to improve drug treatment
and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and
neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers
and clinicians from incorporating more powerful computational and predictive methods in addiction research.
The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome
is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions
to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that
influence drug abuse risk and treatment. In the Transcriptome Informatics and Mechanisms research core we
assemble and upgrade hundreds of large genome (DNA) and transcriptome (RNA) datasets for experimental
rodent (rat) models of addiction. In the Systems Analytics and Modeling research core, we are using innovative
systems genetics methods (gene mapping) to understand the linkage between DNA differences, environmental
risks such as stress, and the differential risk of drug abuse and relapse. Our Pilot core is catalyzing new
collaborations among young investigator in the field of addiction research. In sum the Center is a national
resource for more reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and
integrating high quality data, metadata, using open software systems in collaboration with many other teams of
researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research
relevant to addiction research.
成瘾是一种高度复杂的疾病,危险因素包括遗传变异和差异
发展,性别和环境。精确医学改善药物治疗的长期潜力
预防取决于获得更好地了解遗传学,药物,脑细胞和
神经元电路相互作用以影响行为。有严重的技术障碍可以阻止研究人员
以及将更强大的计算和预测方法纳入成瘾研究中的临床医生。
NIDA P30 OMICS,系统遗传学和上瘾的核心核心核心核心中心的目的
是为NIH,NIDA,NIAAA和其他联邦和州机构提供支持的研究人员的能力和培训
使用更多定量和可检验的方法来分析遗传,表观遗传学和环境因素
影响滥用药物的风险和治疗。在转录组信息学和机制研究核心中
组装和升级数百个大基因组(DNA)和转录组(RNA)数据集用于实验
啮齿动物(大鼠)成瘾模型。在系统分析和建模研究核心中,我们正在使用创新
系统遗传学方法(基因映射)以了解DNA差异,环境之间的联系
压力等风险以及药物滥用和复发的差异风险。我们的飞行员核心正在催化新的
成瘾研究领域的年轻研究者之间的合作。总而言之
用于成瘾中更多可再现研究的资源。我们正在集中,归档,分发,分析和
集成高质量数据,元数据,使用开放软件系统与许多其他团队合作
研究人员。我们的目标是帮助NIDA成瘾的门户网站,其中包括所有基因组研究
与成瘾研究有关。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice.
- DOI:10.3389/fgene.2021.659012
- 发表时间:2021
- 期刊:
- 影响因子:3.7
- 作者:Parks C;Rogers CM;Prins P;Williams RW;Chen H;Jones BC;Moore BM 2nd;Mulligan MK
- 通讯作者:Mulligan MK
Paraquat Toxicogenetics: Strain-Related Reduction of Tyrosine Hydroxylase Staining in Substantia Nigra in Mice.
- DOI:10.3389/ftox.2021.722518
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Torres-Rojas C;Zhao W;Zhuang D;O'Callaghan JP;Lu L;Mulligan MK;Williams RW;Jones BC
- 通讯作者:Jones BC
Systems Genetics for Evolutionary Studies.
- DOI:10.1007/978-1-4939-9074-0_21
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:P. Prins;G. Smant;D. Arends;Megan K. Mulligan;Rob Williams;R. Jansen
- 通讯作者:P. Prins;G. Smant;D. Arends;Megan K. Mulligan;Rob Williams;R. Jansen
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Laura Maren Saba其他文献
Laura Maren Saba的其他文献
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{{ truncateString('Laura Maren Saba', 18)}}的其他基金
Overall NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome
总体而言,NIDA 转录组学、系统遗传学和成瘾组核心“卓越中心”
- 批准号:
9360448 - 财政年份:2017
- 资助金额:
$ 74.5万 - 项目类别:
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Overall NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome
总体而言,NIDA 转录组学、系统遗传学和成瘾组核心“卓越中心”
- 批准号:
9360448 - 财政年份:2017
- 资助金额:
$ 74.5万 - 项目类别: