UChicago Interdisciplinary Cancer Health Disparities SPORE

芝加哥大学跨学科癌症健康差异 SPORE

基本信息

批准号：
10175869
负责人：
Dezheng Huo
金额：
$ 16.2万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175869
关键词：
2019-nCoV Address Admission activity Affect African American Age Anxiety Area Breast Cancer Patient Breast Cancer Treatment Breast Cancer survivor COVID-19 COVID-19 pandemic Cancer Patient Cancer Survivor Case Fatality Rates Catchment Area Caucasians Cessation of life Chicago Chronic lung disease Code Communities Coronavirus Coronavirus Infections County Data Diabetes Mellitus Disease Disease Outbreaks Disease Progression Elderly Electronic Health Record Emergency Situation Enrollment Epidemiology Evaluation Exposure to Funding Grant Health system Healthcare High-Risk Cancer Histologic Hypertension Illinois Incidence Infection Interruption Intervention Interview Knowledge Latino Loneliness Malignant Neoplasms Outcome Patients Persons Phenotype Population Psychological Impact Public Health Quality of life Race Recording of previous events Resources Risk Risk Factors Severities Severity of illness Side Social isolation Social support Stress Surveys Telemedicine Translational Research United States Universities Woman aged cancer health disparity cancer therapy care delivery cohort comorbidity cooking economic impact ethnic minority population follow-up health disparity health economics high risk indexing infection rate interest malignant breast neoplasm member metropolitan mortality news novel coronavirus pandemic disease programs racial and ethnic racial difference racial disparity racial health disparity response satisfaction screening guidelines survivorship telehealth ventilation

项目摘要

This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOTCA-20-042. The ongoing pandemic of the coronavirus disease 2019 (COVID-19) is a public health and economic emergency that has disrupted the lives of breast cancer patients. Unfortunately, it has hit the United States heavily with more than 1.7 million people having been infected and more than 100,000 lives lost to date. While old age and having comorbidities are risk factors for dying from COVID-19, there is also a racial disparity in COVID-19 severity, with black and Latino patients in urban centers dying disproportionately from COVID-19. Breast cancer is the most common malignancy in women, with over 3.8 million women living in the United States with a history of invasive breast cancer. African Americans with breast cancer have an elevated risk of all-cause mortality and breast cancer-specific mortality. During the COVID-19 pandemic, it is important to understand the impact of SARS-CoV-2 infection and COVID-19 on breast cancer disease progression, care delivery, and survivorship including quality of life during and after the COVID-19 outbreak. In response to the needs of patients participating in our P20 funded UChicago Interdisciplinary Health Disparities SPORE and to address these knowledge gaps, we propose to engage with the Community by conducting an online survey, reviewing electronic health records, and searching the National Death Index to determine status of 3,059 breast cancer patients in the Chicago Multiethnic Epidemiologic Breast Cancer Cohort. The project has three specific aims: First, we will evaluate the extent of treatment interruption because of COVID-19 outbreak, and understand the utilization and satisfaction with Telehealth. Second, we will conduct a holistic evaluation of COVID-19 and mitigation efforts on loneliness, anxiety, stress, economic impact, and lack of resources among breast cancer patients. Third, we will estimate the coronavirus infection rate, severity and case-fatality rate of COVID-19, and identify factors associated with severity and case-fatality rate of COVID-19. For each aim, we will examine racial differences to understand whether COVID-19 has worsened previously identified mortality gap in the Cohort. The Supplementary Project will greatly enhance our SPORE P20 program by supporting additional interviews and follow-up of the cancer cohort members, and will generate necessary data regarding the impact of COVID-19 epidemic and lockdown on translational research to close the mortality gap in our proposed full SPORE application. These data are critical for guiding both community level interventions and health systems adaptation to support high-risk patients in the era of COVID-19.

本申请是为了响应标识为 NOTCA-20-042 的特殊利益通知 (NOSI) 而提交的。 2019 年冠状病毒病 (COVID-19) 的持续流行是一场公共卫生和经济紧急事件，扰乱了乳腺癌患者的生活。不幸的是，它对美国造成了严重打击，迄今为止已有超过 170 万人被感染，超过 10 万人丧生。虽然年老和患有合并症是死于 COVID-19 的危险因素，但 COVID-19 的严重程度也存在种族差异，城市中心的黑人和拉丁裔患者死于 COVID-19 的比例不成比例。乳腺癌是女性最常见的恶性肿瘤，在美国有超过 380 万女性有浸润性乳腺癌病史。患有乳腺癌的非裔美国人的全因死亡率和乳腺癌特异性死亡率的风险较高。在 COVID-19 大流行期间，了解 SARS-CoV-2 感染和 COVID-19 对乳腺癌疾病进展、护理服务和生存（包括 COVID-19 爆发期间和之后的生活质量）的影响非常重要。为了满足参与 P20 资助的芝加哥大学跨学科健康差异 SPORE 的患者的需求并解决这些知识差距，我们建议通过进行在线调查、审查电子健康记录和搜索国家死亡指数来确定社区的参与程度芝加哥多民族流行病学乳腺癌队列中 3,059 名乳腺癌患者的状况。该项目有三个具体目标：首先，我们将评估因 COVID-19 爆发而导致治疗中断的程度，并了解远程医疗的利用率和满意度。其次，我们将对 COVID-19 以及乳腺癌患者的孤独、焦虑、压力、经济影响和资源缺乏的缓解措施进行全面评估。第三，我们将估计COVID-19的冠状病毒感染率、严重程度和病死率，并确定与COVID-19的严重程度和病死率相关的因素。对于每个目标，我们将检查种族差异，以了解 COVID-19 是否加剧了先前确定的队列中的死亡率差距。补充项目将通过支持对癌症队列成员的额外访谈和随访来极大地增强我们的 SPORE P20 计划，并将生成有关 COVID-19 流行病和封锁对转化研究的影响的必要数据，以缩小我们提议的死亡率差距完整的 SPORE 应用程序。这些数据对于指导社区层面的干预措施和卫生系统适应以支持 COVID-19 时代的高危患者至关重要。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Validation of the RSClin risk calculator in the National Cancer Data Base.

在国家癌症数据库中验证 RSClin 风险计算器。

DOI：
10.1002/cncr.35163
发表时间：
2024
期刊：
Cancer
影响因子：
6.2
作者：
Vannier,AugustinGL;Dhungana,Asim;Zhao,Fangyuan;Chen,Nan;Shubeck,Sarah;Hahn,OlwenM;Nanda,Rita;Jaskowiak,NoraT;Fleming,GiniF;Olopade,OlufunmilayoI;Pearson,AlexanderT;Huo,Dezheng;Howard,FrederickM
通讯作者：
Howard,FrederickM

Demographic and Clinical Characteristics Associated With Familiarity, Interest, and Use of Integrative Therapies Among Patients With Breast Cancer.

DOI：
10.1177/15347354231185122
发表时间：
2023-01
期刊：
Integrative cancer therapies
影响因子：
2.9
作者：
通讯作者：

Racial Disparities in Pathological Complete Response Among Patients Receiving Neoadjuvant Chemotherapy for Early-Stage Breast Cancer.

DOI：
10.1001/jamanetworkopen.2023.3329
发表时间：
2023-03-01
期刊：
JAMA NETWORK OPEN
影响因子：
13.8
作者：
Zhao, Fangyuan;Miyashita, Minoru;Hattori, Masaya;Yoshimatsu, Toshio;Howard, Frederick;Kaneva, Kristiyana;Jones, Ryan;Bell, Joshua S. K.;Fleming, Gini F.;Jaskowiak, Nora;Nanda, Rita;Zheng, Yonglan;Huo, Dezheng;Olopade, Olufunmilayo I.
通讯作者：
Olopade, Olufunmilayo I.

Response to Treatment, Racial and Ethnic Disparity, and Survival in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy in the US.