Administration and Data Integration Core

管理和数据集成核心

基本信息

批准号：
10172232
负责人：
Hui Zheng
金额：
$ 24.08万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10172232
关键词：
Aging Agreement Alzheimer&apos s Disease Atlases Award Bioinformatics Biology Brain Businesses ChIP-seq Collaborations Communication Communities Conflict (Psychology)Consult Consultations Data Data Analyses Data Set Ensure Evaluation Funding Human Resources Individual Infrastructure Leadership Licensing Lysosomes Medicine Molecular and Cellular Biology Multiomic Data Notification Occupational activity of managing finances Online Systems Output Process Program Research Project Grants Proteome Proteomics Reagent Regulation Reporting Research Research Personnel Resources Sampling Scientist Signal Transduction Site Tauopathies Time United States National Institutes of Health Universities Videoconferencing Visualization Washington Work college conflict resolution data integration data resource data sharing lectures medical schools meetings member metabolome metabolomics mid-career faculty multiple omics programs recruit success synergism transcriptome sequencing

项目摘要

The objectives of the Administration and Data Integration Core (Core A) are three-fold: first, the Core will provide administrative support and financial management of the Program Project Grant (PPG); second, the Core will support cross-platform bioinformatics integration and sharing of multi-omic datasets generated by the Cores and Projects; third, the Core will facilitate interactions between the Cores and Projects, as well as between Baylor College of Medicine (BCM) and Washington University School of Medicine (WU), and will also provide overall scientific leadership of the PPG. The Core will be led by Dr. Hui Zheng, Director of the Huffington Center on Aging (HCOA) at BCM, and housed within the HCOA administrative unit. The Core will be co-led by Dr. Cristian Coarfa, Associate Professor of Molecular and Cellular Biology and an expert in integrative analysis and visualization of multi-omic data, who will oversee the bioinformatics and data sharing aspects of the PPG. To ensure effective management and successful execution of the objectives, a Scientific Advisory Board (SAB) will be formed upon notification of award that will be composed of three members with established leadership and scientific expertise in AD, tauopathy, aging, lysosomal biology, proteomics, and metabolomics. The Core will consult with the SAB for overall program management and scientific direction. The Core has also recruited individuals from BCM and WU who will offer support on institutional resources and advice on conflict resolution if needed. The specific aims of the Administration and Data Integration Core are as follows: 1) Provide overall scientific leadership; 2) Provide financial, administrative, and organizational support; 3) Perform multi-omics data analysis and integration and ensure rapid public access to the datasets; 4) Generate a web-based first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas) of the lysosomal proteome and metabolome. Overall, the core is ultimately responsible for the PPG’s success, and will work with NIH and SAB closely to ensure that the team as a whole achieves its milestones and deliverables.

管理和数据集成核心（核心 A）的目标有三个：首先，该核心将第二，提供计划项目补助金（PPG）的行政支持和财务管理； Core将支持跨平台生物信息学集成和共享由该平台生成的多组学数据集核心和项目；第三，核心将促进核心和项目之间的互动，以及贝勒医学院 (BCM) 和华盛顿大学医学院 (WU) 之间的合作，并且还将该核心将由主任 Hui Cheng 博士领导。 BCM 的赫芬顿老龄化中心 (HCOA) 位于 HCOA 行政部门内。由分子和细胞生物学副教授兼专家 Cristian Coarfa 博士共同领导多组学数据的综合分析和可视化，谁将监督生物信息学和数据共享为了确保有效管理和成功执行 PPG 的各个方面，我们制定了科学的计划。顾问委员会 (SAB) 将在获奖通知后成立，由三名成员组成，在 AD、tau 病、衰老、溶酶体生物学、蛋白质组学和代谢组学核心将与 SAB 协商整体计划管理和科学方向。核心还从 BCM 和 WU 招募了个人，他们将提供机构资源和支持管理和数据集成核心的具体目标是（如果需要）提供有关冲突解决的建议。如下： 1) 提供全面的科学领导； 2) 提供财务、行政和组织方面的领导；支持；3）进行多组学数据分析和整合，并确保公众快速访问数据集； 4) 生成基于网络的一流衰老和 Tau 病相关溶酶体图谱 (ATLas) 总体而言，核心对 PPG 的成功负有最终责任。将与 NIH 和 SAB 密切合作，确保团队作为一个整体实现其里程碑，可交付成果。