Promoting Genetic Counseling among African American Women with Hereditary Risk for Breast Cancer

促进有乳腺癌遗传风险的非裔美国女性的遗传咨询

• 批准号: 10166807
• 负责人: Vida Ann Henderson
• 金额: $ 16.07万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166807
• 关键词: Address; Advisory Committees; Affect; African American; Applications Grants; Award; Awareness; BRCA1 gene; Behavioral; Behavioral Model; Breast Cancer Risk Factor; Cancer Center; Chicago; Clinical Research; Counseling; Coupled; DNA Sequence Alteration; Data; Decision Aid; Decision Making; Development; Development Plans; Diffusion; Discipline; Distress; Early Diagnosis; Educational workshop; Ensure; Epigenetic Process; Family member; Federally Qualified Health Center; Funding; General Population; Genes; Genetic; Genetic Counseling; Genetic Services; Goals; Grant; Guidelines; High Risk Woman; Illinois; Individual; Inherited; Intervention; Knowledge; Lead; Malignant Neoplasms; Mentors; Mentorship; Methods; Minority; Mission; Multimedia; Neighborhood Health Center; Not Hispanic or Latino; Pamphlets; Participant; Pathogenicity; Pathway Analysis; Physicians; Population Heterogeneity; Positioning Attribute; Preventive service; Primary Health Care; Productivity; Provider; Psychosocial Factor; Public Health; Public Health Schools; Randomized Controlled Trials; Recommendation; Research; Research Activity; Research Personnel; Risk; Scientist; Self Determination; Services; Social Network; Structure; Testing; Time; Training; Training Activity; Translational Research; United States; Universities; Variant; Woman; Work; Writing; cancer genetics; cancer health disparity; cancer prevention; career; career development; cost; design; effectiveness testing; emotional distress; ethnic minority population; genetic risk assessment; genetic testing; health service use; hereditary risk; high risk; high risk population; hormone receptor-negative; improved; intrinsic motivation; malignant breast neoplasm; meetings; minority communities; mortality; multidisciplinary; precision medicine; racial and ethnic; risk perception; skills; social; social relationships; socioeconomics; tool; tumor; underserved minority; uptake

1 The long-term career goal of this K01 project is to gain training and mentorship that will prepare me for a career 2 as an independent and successful externally funded investigator in the field of cancer health disparities. Over 3 the next 5 years, my career objectives are to: 1) develop and lead experimental interventions; 2) gain further 4 expertise in translational science; 3) acquire skills in quantitative analysis, including social network analysis; and 5 4) enhance my ability to write competitive grant applications and increase my scholarly productivity. With my 6 primary mentor, Dr. Marian Fitzgibbon, I have assembled a strong team of co-mentors and advisors (including a 7 biostatistician) to guide me through the proposed training and research activities. The proposed career 8 development plan is structured to ensure that I achieve training milestones through didactic coursework, career 9 development workshops, and attendance at national scientific meetings. The University of Illinois at Chicago 10 (School of Public Health and Cancer Center) are committed to supporting my career development and providing 11 the protected time needed to achieve my career and research goals. The overall objective of this K01 research 12 project is to test the effectiveness of a culturally targeted video, previously developed by our research team, on 13 promoting genetic counseling attendance among African American (AA) women determined to be at high risk for 14 breast cancer through cancer genetic risk assessment at a Federally Qualified Health Center. Uptake of genetic 15 services is particularly low among high-risk AA women, who carry a disproportionate burden of breast cancer 16 mortality. Further, although testing close relatives of individuals who test positive for a pathogenic variant might 17 curtail breast cancer disparities attributable to hereditary risk, it is unclear how counseled or tested individuals 18 influence their social and familial networks. Thus, my central hypothesis is that the culturally targeted video will 19 increase genetic counseling attendance among participants compared to those who receive a genetic counseling 20 brochure. The proposed Specific Aims are to: 1) compare the effects of the video and brochure on genetic 21 counseling attendance among AA women at high risk for breast cancer; 2) test how psychosocial factors 22 (knowledge, intrinsic motivation, risk perception, distress) affect relationships between intervention exposures 23 (video/brochure) and genetic counseling attendance; and 3) compare the impact of intervention exposures 24 (video/brochure) on diffusion of knowledge through social network analysis. My prior training, coupled with the 25 skills that I will acquire during the award period, will equip me to successfully conduct the proposed research 26 and position me to continue my work to address breast cancer disparities that persist among high-risk AA women. 27 28 29 30 31 32

1这个K01项目的长期职业目标是获得培训和指导，这将使我为职业做好准备 2作为癌症健康差异领域的独立且成功的外部资助研究者。超过 3接下来的5年，我的职业目标是：1）开发和领导实验干预； 2）进一步增加 4转化科学专业知识； 3）获得定量分析的技能，包括社交网络分析；和 5 4）增强我编写竞争性赠款应用程序并提高我的学术生产力的能力。和我的 6主要导师，玛丽安·菲茨宾博士（Marian Fitzgibbon），我组建了一支强大的联合和顾问团队（包括一个 7生物统计学家）指导我完成拟议的培训和研究活动。拟议的职业 8开发计划的结构是确保我通过教学课程，职业实现培训里程碑 9个发展研讨会，并参加了国家科学会议。伊利诺伊大学芝加哥 10（公共卫生和癌症中心）致力于支持我的职业发展并提供 11实现我的职业和研究目标所需的受保护时间。这项K01研究的总体目标 12项目是测试以前由我们的研究团队开发的具有文化针对视频的有效性， 13促进非裔美国人（AA）妇女的遗传咨询出勤 14通过癌症遗传风险评估在联邦资格的健康中心进行的乳腺癌。遗传的吸收 在高风险的AA妇女中，15个服务尤其低，她们承担乳腺癌负担不成比例的服务 16死亡率。此外，尽管测试对致病变异呈阳性的个体的近亲可能 17降低乳腺癌的差异归因于遗传风险，目前尚不清楚如何咨询或测试个人 18影响他们的社会和家族网络。因此，我的中心假设是，以文化为目标的视频将 与接受遗传咨询的人相比，参与者的遗传咨询出勤率增加19 20小册子。提出的特定目的是：1）比较视频和小册子对遗传的影响 21 AA妇女的咨询症状出勤；乳腺癌风险高； 2）测试心理因素如何 22（知识，内在动机，风险感知，困扰）影响干预暴露之间的关系 23（视频/小册子）和遗传咨询出勤； 3）比较干预暴露的影响 24（视频/小册子）通过社交网络分析扩散知识。我先前的培训，加上 我将在奖励期间获得的25个技能，将使我能够成功进行拟议的研究 26并将我继续工作，以解决高危AA妇女持续存在的乳腺癌差异。 27 28 29 30 31 32