Establishing the science behind Alzheimer's recruitment registries: opportunities for increasing diversity and accelerating enrollment into trials

建立阿尔茨海默病招募登记背后的科学：增加多样性和加速试验注册的机会

• 批准号: 10170070
• 负责人: Amy Bleakley
• 金额: $ 38.79万
• 依托单位: BANNER HEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170070
• 关键词: Adherence; Adult; Adult Children; Affect; African American; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease risk; Attitude; Award; Behavior; Behavioral Model; Belief; COVID-19; COVID-19 pandemic; Contracts; Cross-Sectional Studies; Data; Disease Outbreaks; Elderly; Enrollment; Environment; Ethnic group; Exposure to; Future; Geography; Goals; Health; Health behavior; Hispanics; Hygiene; Individual; Interest Group; Mass Media; Mediating; Methods; Minority Enrollment; Misinformation; Monitor; Morbidity - disease rate; Nature; Not Hispanic or Latino; Parents; Patient Recruitments; Perception; Population; Predisposition; Preparation; Prevention; Prevention Research; Prevention trial; Race; Registries; Reporting; Research; Risk; Sampling; Science; Series; Social Distance; Source; Surveys; Testing; Time; Underrepresented Groups; Underrepresented Populations; Vaccines; Virus; Vulnerable Populations; base; behavior influence; brain health; disparities in morbidity; ethnic minority population; experience; follow-up; health disparity; high risk; mortality; news; pandemic disease; prevent; programs; psychosocial; racial and ethnic; racial disparity; racial minority; recruit; social media; theories; willingness; young adult

PROJECT SUMMARY/ABSTRACT With the singular focus on COVID-19 in both the media environment and in the everyday lives of most people, it is not clear how perceptions of other health conditions may shift, especially among older adults who are particularly vulnerable to COVID-19. Research demonstrates a tendency for individuals to allow their attitudes towards one salient issue to impact their attitudes and behaviors towards unrelated, but similar other issues (i.e., spillover effects). Given the emphasis on science and research in COVID-19 discourse, it is important to assess whether older adults’ pandemic experiences may “spillover” to their perceptions of scientific research in ways that may affect their willingness to participate in Alzheimer’s disease (AD)-related research efforts. In this project, we propose to examine how information sources on COVID-19 and the larger context of the pandemic influence older adults’ perceptions of scientific research and AD, adherence to recommended COVID-19 prevention behaviors, and whether these perceptions vary by racial/ethnic group. This research is critical to determine whether COVID-19 spillover is changing how individuals perceive both AD as a health risk and calls to participate in AD research such as enrolling in recruitment registries. Grounded in Spreading Activation Theory and the Reasoned Action Approach (RAA), we propose two aims. First, to determine the extent to which COVID-19 news coverage and lived experiences change perceptions of scientific research and willingness to participate in AD-related research, we employ a mixed methods approach using surveys and content analysis. We conduct a series of repeated cross-sectional surveys over a period of 12 months to monitor how changes in the pandemic and in news coverage may be related to attitude shifts about research generally and specific to AD and AD risk. Survey data will be collected across 12 waves from a national sample stratified by the race groups that correspond to the groups of interest in the parent award (white, Hispanic, Black). Data are collected monthly, which allows for capturing perceptual shifts as the COVID-19 situation changes rapidly. A theory-driven content analysis of news coverage from main news sources, coinciding with the surveys, will also be conducted with the goal of understanding the extent and nature of COVID-19 information and misinformation, including topics such as racial disparities in COVID-19 morbidity and mortality and emphasis on older adults and racial minorities as vulnerable populations. The second aim identifies relevant psychosocial determinants (attitudes, norms, efficacy/control) of subsequent COVID-19- related health behaviors (i.e., preparation, prevention) for older adults using the RAA. We collect a follow-up wave of data (Wave 2) from the Wave 1/Baseline from the repeated cross-sectional surveys and predict how effects of exposure to media and interpersonal messages are mediated through attitudes, norms, and efficacy to predict subsequent COVID-19 recommended behaviors. Together these two aims allow for a test of COVID- 19 spillover into AD-related attitudes and willingness to participate in AD research.

项目摘要/摘要 在媒体环境和大多数人的日常生活中，人们都关注于19号， 目前尚不清楚对其他健康状况的看法如何发生变化，尤其是在 特别容易受到covid-19的影响。研究证明了个人允许与会者的趋势 解决一个突出的问题，以影响其与会者和行为对无关，但其他类似的问题 （即Spilover效应）。考虑到Covid-19话语中的科学与研究的重视，重要的是 评估老年人的大流行经历是否可能“溢出”他们对科学研究的看法 可能影响他们参与阿尔茨海默氏病（AD）相关的研究工作的方式。在这个 项目，我们建议研究如何在COVID-19和大流行的更大背景下进行信息来源 影响老年人对科学研究和AD的看法，遵守推荐的Covid-19 预防行为​​以及这些观念是否因种族/族裔群体而异。这项研究对 确定Covid-19 Spilover是否正在改变个人将广告视为健康风险和呼叫的方式 参与广告研究，例如参加招聘注册表。基于扩散激活 理论和理性行动方法（RAA），我们提出了两个目标。首先，确定范围 COVID-19的新闻报道和现场经历改变了科学研究的看法和 愿意参与与广告相关的研究，我们使用调查采用混合方法， 内容分析。我们在12个月内进行了一系列重复的横截面调查 监视大流行和新闻报道的变化与研究的态度转变有关 通常，特定于AD和AD风险。调查数据将在一个国家的12波中收集 由种族组分层的样本，与父母奖的感兴趣群体相对应（怀特， 西班牙裔，黑色）。数据每月收集，该数据允许捕获感知变化作为COVID-19 情况迅速变化。由理论驱动的内容分析主要新闻来源的新闻报道， 与调查一致，还将进行了解 COVID-19信息和错误信息，包括诸如Covid-19发病率的种族差异之类的主题 死亡率和重视老年人和少数群体作为脆弱人群。第二个目标 确定随后的COVID-19-- 使用RAA的老年人相关的健康行为（即准备，预防）。我们收集后续行动 从波浪1/基线的数据波（波2）从重复的横截面调查中，并预测如何 接触媒体和人际信息的影响是通过与会者，规范和有效性介导的 预测随后的Covid-19建议行为。这两个目的共同测试了共​​同的测试 19 Spilover成为与广告相关的与会者，并愿意参加广告研究。