Enhancing Pediatric Treatment Adherence and Health Outcomes

提高儿科治疗依从性和健康结果

• 批准号: 10160937
• 负责人: Kevin Hommel
• 金额: $ 27.24万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-04 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10160937
• 关键词: Childhood; Health; Outcome; treatment adherence

PROJECT SUMMARY This proposal requests continued support for the “Enhancing Pediatric Treatment Adherence and Health Outcomes” (T32 HD068223) postdoctoral training program, which trains M.D. and Ph.D. researchers to assume leadership roles in developing innovative, high impact research on adherence to medical treatment and chronic illness management that will enhance the health outcomes of children with chronic conditions. Modern medical treatments have improved the health outcomes of large numbers of children and adolescents with chronic conditions. However, one of the most critical remaining barriers to improving children's health outcomes over the course of their lifetime is nonadherence to prescribed medical treatment. As noted by the World Health Organization (WHO), treatment nonadherence is highly prevalent (rates of ≥ 50% in pediatric chronic illness populations) and has a significantly negative impact on children's health and health care costs. Continued innovative and clinically relevant research is needed to close the gap between the health outcomes that are potentially achievable with more optimal treatment adherence and those achieved in current practice. NIH program priorities and requests for applications, scientific consensus conferences, and scholarly reviews have all identified the critical importance of research on pediatric adherence to treatment. A critical barrier to scientific advances in pediatric adherence and chronic illness management research is the shortage of talented, well-trained researchers who are devoting their careers to developing innovative, high impact treatment adherence and chronic illness management research with pediatric populations. One of the most promising ways to address this need and improve child health is to develop innovative interdisciplinary research training programs to train leaders in the field of treatment adherence and chronic illness management research. This is the focus of this T32 program. Thus far, we have trained several fellows who are developing promising independent research careers in pediatric adherence and chronic illness management. Specific training innovations involve the integration of biomedical, behavioral, biostatistics, and health services/outcomes research and are reflected in a comprehensive training curriculum and research opportunities. Research innovations include novel methods of adherence assessment and intervention involving technology designed to enhance the engagement of children and adolescents, improve the power and duration of intervention effects, and reach diverse populations who cannot easily access traditional clinic- based approaches. Program innovation is also enhanced by novel research training opportunities to evaluate the comparative effectiveness of adherence promotion interventions in pediatric chronic illness management, to integrate objective methods of adherence measurement (e.g., behavioral, pharmacological, technological) and conduct advanced statistical analyses to evaluate the impact of adherence promotion interventions on children's health outcomes.

项目概要 该提案要求继续支持“增强儿科治疗依从性和健康” 结果”（T32 HD068223）博士后培训计划，培训医学博士和博士研究人员 在开展关于坚持医疗治疗的创新、高影响力研究方面发挥领导作用 慢性病管理将改善患有慢性病的儿童的健康状况。 现代医学治疗改善了大量儿童和青少年的健康状况 然而，慢性病是改善儿童健康的最重要障碍之一。 正如所指出的，他们一生的结果是不遵守规定的医疗。 世界卫生组织 (WHO)，治疗不依从的现象非常普遍（儿科中的比率≥ 50%） 慢性疾病人群），并对儿童的健康和医疗保健费用产生显着的负面影响。 需要持续的创新和临床相关研究来缩小健康之间的差距 通过更优化的治疗依从性可能实现的结果以及当前实现的结果 NIH 项目优先事项和申请要求、科学共识会议和学术。 所有评论都指出了儿科治疗依从性研究的至关重要性。 儿科依从性和慢性病管理研究科学进步的障碍是短缺 一群才华横溢、训练有素的研究人员，他们致力于开发创新、高影响力的研究 针对儿科人群的治疗依从性和慢性病管理研究是最重要的研究之一。 解决这一需求和改善儿童健康的有希望的方法是开发创新的跨学科 研究培训计划，培训治疗依从性和慢性病管理领域的领导者 这是T32项目的重点，到目前为止，我们已经培训了几位正在开发的研究员。 在儿科依从性和慢性病管理方面有前途的独立研究职业。 具体培训创新涉及生物医学、行为、生物统计学和健康的整合 服务/成果研究并反映在综合培训课程和研究中 研究创新包括依从性评估和干预的新方法。 涉及旨在增强儿童和青少年参与度、提高力量的技术 和干预效果的持续时间，并覆盖无法轻易获得传统诊所的不同人群 基于方法的新研究培训机会也增强了项目创新。 儿科慢性病管理中依从性促进干预措施的比较有效性， 整合依从性测量的客观方法（例如行为、药理学、技术） 并进行高级统计分析，以评估依从性促进干预措施对 儿童的健康结果。