Utah Center for Clinical and Translational Science

犹他州临床和转化科学中心

• 批准号: 10162753
• 负责人: WILLARD H. DERE
• 金额: $ 10.55万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162753
• 关键词: Academic Medical Centers; Achievement; Address; Administrative Efficiency; Advocacy; African; African American; Area; Biomedical Research; Cities; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Communities; Community Outreach; Complement; Computer software; Data; Data Collection; Disease; Diverse Workforce; Ecosystem; Education; Ensure; Environment; Ethics; Evaluation; Face; Fostering; Foundations; Funding; Genes; Genetic; Genomics; Goals; Health; Health Care Research; Health Professional; Health system; Healthcare; Healthcare Systems; Idaho; Informatics; Infrastructure; International; Knowledge; Latino; Leadership; Learning; Longevity; Medicare; Methodology; Methods; Mission; Native Americans; Participant; Patients; Positioning Attribute; Principal Investigator; Prize; Process; Public Health; Randomized; Refugees; Reproducibility; Research; Research Infrastructure; Research Methodology; Research Project Grants; Research Training; Resource Sharing; Resources; Rural; Science; Scientific Advances and Accomplishments; Services; Sodium Chloride; Statistical Methods; Structure; Surrogate Markers; Time; Training; Training and Infrastructure; Translational Research; Translations; Underrepresented Minority; Universities; Utah; Veterans; Work; Wyoming; base; burden of illness; career; clinical center; data acquisition; educational atmosphere; experience; frontier; implementation science; improved; innovation; member; minority communities; multidisciplinary; named group; novel; programs; quality improvement organization; sharing platform; skills; software development; suburb; tool; translational impact; translational pipeline

Contact PD/PI: Dere, Willard H. ABSTRACT - OVERALL The University of Utah Center for Clinical and Translational Science (CCTS) serves as the central locus of translational research in the Intermountain West. The CCTS has become the center for combining the efforts of the University of Utah and its partners into a vibrant research enterprise which advances both clinical projects and the science of translational research. To realize these goals, the CCTS is led by Co-Principal Investigators Drs. Dere and Hess, who are well positioned within institutional leadership and are supported by a variety of institutional initiatives and resources that complement the CCTS activities. The Co-PIs are supported by an integrated group of experienced local, regional, and national leaders and are guided by a comprehensive oversight structure that anchors the CCTS within the University of Utah and its partners. Our proposal builds on a firm foundation of achievements in areas of strength which include but are not limited to: our genetics programs, which has led to discoveries of numerous disease-causing genes and to a variety of software platforms that are used in computational genomics globally; our community-outreach efforts, highlighted by state- and nationwide initiatives by key leaders; our statistical methods and software developed to evaluate surrogate markers; and our substantive experiences in clinical trials, both traditional randomized and pragmatic, and multi-center collaboration networks, which continue to study a variety of special populations identified by the recent NCATS Lifespan initiatives. By supporting successful trainees at all levels and preparing them for productive careers, we are building a diverse workforce able to use our extensive infrastructure to advance national CTSA goals. The breadth of the CCTS activities allows it to address established and emerging institutional issues by providing timely resources, advice, and services. We look forward to addressing major public health and translational research issues through a comprehensive suite of services, as well as a culture that prizes team science and high quality research in order to better ensure research reproducibility. We seek to achieve our goals through four specific aims: (1) Catalyze clinical and translational research as the CTSA hub for the Intermountain West; (2) Advance and refine an educational environment that maximizes the value of collaboration and training among various stakeholders; (3) Integrate diverse partners for meaningful collaborations in research endeavors across the translational spectrum; (4) Promote efficient and effective data collection, analyses, and sharing that leverages innovative informatics- based solutions. Project Summary/Abstract Page 282 Contact PD/PI: Dere, Willard H.

联系PD/PI：Dere，Willard H. 摘要 - 总体 犹他大学临床与转化科学中心（CCTS）是 西部座位的翻译研究。 CCT已成为结合努力的中心 犹他大学及其合作伙伴成为一个充满活力的研究企业，该企业都在两个临床项目中推进 和转化研究科学。为了实现这些目标，CCT是由联合主持调查员领导的 博士。德尔（Dere）和赫斯（Hess 与CCT活动相辅相成的机构计划和资源。 Co-Pis由 由经验丰富的地方，地区和国家领导人组成的综合群体，并受到全面的指导 监督结构，将CCT固定在犹他大学及其合作伙伴内。我们的建议建立 在实力领域的牢固成就基础上，包括但不限于：我们的遗传学 程序，导致发现了许多引起疾病的基因和各种软件 全球计算基因组学中使用的平台；我们的社区 - 截然努力，由 主要领导人的国家和全国倡议；我们开发了用于评估的统计方法和软件 替代标记；以及我们在临床试验中的实质性经验，包括传统随机和 务实和多中心协作网络，这些网络继续研究各种特殊人群 由最近的NCAT寿命计划确定。通过支持各个级别的成功学员， 为他们的生产职业做好准备，我们正在建立一个能够使用我们广泛的劳动力 促进国家CTSA目标的基础设施。 CCTS活动的广度使其可以解决 通过提供及时的资源，建议和服务来建立和新兴的机构问题。我们看 通过全面的套件来解决重大的公共卫生和转化研究问题 服务以及一种奖励团队科学和高质量研究的文化，以便更好地确保 研究可重复性。我们试图通过四个具体目标来实现我们的目标：（1）催化临床和 翻译研究是西部座座座的CTSA枢纽； （2）进步并完善教育 在各种利益相关者之间最大化协作和培训价值的环境； （3）集成 在翻译范围内研究工作中有意义合作的多元化合作伙伴； （4） 促进有效有效的数据收集，分析和共享，以利用创新的信息学 - 基于解决方案。 项目摘要/摘要页面282 联系PD/PI：Dere，Willard H.