Low Cost OCT Angiography with Spectroscopic Contrast

低成本 OCT 血管造影与光谱对比

• 批准号: 10156095
• 负责人: William Brown
• 金额: $ 25.91万
• 依托单位: LUMEDICA, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10156095
• 关键词: Adopted; Angiography; Blood; Blood Cells; Blood Vessels; Clinical; Computer software; Contrast Media; Defect; Dependence; Detection; Development; Diagnosis; Diagnostic; Fluorescein Angiography; Functional Imaging; Goals; Hemoglobin; Image; Imaging Device; Imaging Techniques; Light; Measures; Methods; Movement; Neurologic; Ophthalmology; Optical Coherence Tomography; Pathology; Pathway interactions; Patients; Pattern; Performance; Perfusion; Pilot Projects; Price; Research; Research Project Grants; Resolution; Retina; Retinal Diseases; Sales; Scanning; Signal Transduction; Skin; Source; Speed; Structure; Symptoms; System; Techniques; Technology; Testing; Three-Dimensional Image; Tissue imaging; Tissues; Validation; base; clinical practice; commercialization; conjunctiva; contrast imaging; cost; design; experimental study; human tissue; image processing; imaging system; implementation cost; improved; in vivo; instrument; instrumentation; interest; new technology; novel; patient screening; programs; research study; sensor; signal processing; spectrograph; systems research; two-dimensional

Project Summary The overall objective of this research project is to develop a low cost implementation of optical coherence tomography based angiography (OCTA). To meet this objective, we propose to incorporate several novel OCT components and techniques into a new OCTA instrument which can be applied in research studies and offers a pathway for commercialization and clinical use. This imaging system will use the agile design capabilities of our low cost OCT engine, which has enabled us to offer the first commercial OCT research system for sale at a price under $10,000. For this project we will implement faster scanning, up to A-scan rates of 80 kHz, implement scan patterns that enhance efficiency of OCTA scan acquisition and expand the spectral range of our OCT system to permit use of spectroscopic information to measure blood oxygenation. OCTA has seen the most interest in assessing retinal vasculature as an alternative to fluorescein angiography (FA) as it avoids the need for a fluorescent contrast agent. Low cost OCTA could expand application of the technique beyond diagnosis of retinal disease in patients with symptoms to include wider patient screening. For this project, we are particularly interested in developing use cases for OCTA in fields beyond ophthalmology, including assessing tissue perfusion and neurological defects. We seek to demonstrate the feasibility of a low cost OCTA system that is suitable for commercialization. To reach this goal, the following Specific Aims are proposed: 1. Development of low cost OCTA engine and analysis software. 2. Adding spectroscopic information to OCTA and 3. Test and validate OCTA system with in vivo pilot studies. Upon completion of this project we will have demonstrated the feasibility of a low cost OCTA for structural and functional imaging of vascular networks and provided justification for further commercial development.

项目摘要 该研究项目的总体目标是开发低成本的光学连贯性 基于断层扫描的血管造影（八八）。为了满足这个目标，我们建议将几本小说纳入OCT 组件和技术成为一种新的Octa仪器，可以应用于研究并提供 商业化和临床使用的途径。该成像系统将使用敏捷的设计功能 我们的低成本OCT Engine，这使我们能够在A上提供第一个商业OCT研究系统 价格低于$ 10,000。对于这个项目，我们将实施更快的扫描速度，高达80 kHz的A扫描率 实施扫描模式，以提高八章扫描获取效率并扩大光谱范围 我们的OCT系统允许使用光谱信息来测量血液氧合。 Octa认为评估视网膜脉管系统是荧光素血管造影的替代方案的最大兴趣 （FA）由于避免了荧光对比剂的需求。低成本八八可以扩大应用的应用 症状患者的视网膜疾病的诊断超出了诊断，包括更广泛的患者筛查。为了 这个项目，我们特别有兴趣在眼科之外的领域中开发八颗的用例， 包括评估组织灌注和神经系统缺陷。我们试图证明低点的可行性 适用于商业化的成本八八系统。为了实现这一目标，以下具体目标是 提议：1。开发低成本八八引擎和分析软件。 2。添加光谱信息 到八八和3。通过体内试验研究测试和验证八颗系统。该项目完成后，我们将 已经证明了低成本八副的可行性，用于血管网络的结构和功能成像 并为进一步的商业发展提供了理由。