Low Cost OCT Angiography with Spectroscopic Contrast

低成本 OCT 血管造影与光谱对比

• 批准号: 10156095
• 负责人: William Brown
• 金额: $ 25.91万
• 依托单位: LUMEDICA, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10156095
• 关键词: Adopted; Angiography; Blood; Blood Cells; Blood Vessels; Clinical; Computer software; Contrast Media; Defect; Dependence; Detection; Development; Diagnosis; Diagnostic; Fluorescein Angiography; Functional Imaging; Goals; Hemoglobin; Image; Imaging Device; Imaging Techniques; Light; Measures; Methods; Movement; Neurologic; Ophthalmology; Optical Coherence Tomography; Pathology; Pathway interactions; Patients; Pattern; Performance; Perfusion; Pilot Projects; Price; Research; Research Project Grants; Resolution; Retina; Retinal Diseases; Sales; Scanning; Signal Transduction; Skin; Source; Speed; Structure; Symptoms; System; Techniques; Technology; Testing; Three-Dimensional Image; Tissue imaging; Tissues; Validation; base; clinical practice; commercialization; conjunctiva; contrast imaging; cost; design; experimental study; human tissue; image processing; imaging system; implementation cost; improved; in vivo; instrument; instrumentation; interest; new technology; novel; patient screening; programs; research study; sensor; signal processing; spectrograph; systems research; two-dimensional

Project Summary The overall objective of this research project is to develop a low cost implementation of optical coherence tomography based angiography (OCTA). To meet this objective, we propose to incorporate several novel OCT components and techniques into a new OCTA instrument which can be applied in research studies and offers a pathway for commercialization and clinical use. This imaging system will use the agile design capabilities of our low cost OCT engine, which has enabled us to offer the first commercial OCT research system for sale at a price under $10,000. For this project we will implement faster scanning, up to A-scan rates of 80 kHz, implement scan patterns that enhance efficiency of OCTA scan acquisition and expand the spectral range of our OCT system to permit use of spectroscopic information to measure blood oxygenation. OCTA has seen the most interest in assessing retinal vasculature as an alternative to fluorescein angiography (FA) as it avoids the need for a fluorescent contrast agent. Low cost OCTA could expand application of the technique beyond diagnosis of retinal disease in patients with symptoms to include wider patient screening. For this project, we are particularly interested in developing use cases for OCTA in fields beyond ophthalmology, including assessing tissue perfusion and neurological defects. We seek to demonstrate the feasibility of a low cost OCTA system that is suitable for commercialization. To reach this goal, the following Specific Aims are proposed: 1. Development of low cost OCTA engine and analysis software. 2. Adding spectroscopic information to OCTA and 3. Test and validate OCTA system with in vivo pilot studies. Upon completion of this project we will have demonstrated the feasibility of a low cost OCTA for structural and functional imaging of vascular networks and provided justification for further commercial development.

项目概要 该研究项目的总体目标是开发一种低成本的光学相干实现方案 基于断层扫描的血管造影（OCTA）。为了实现这一目标，我们建议结合几种新颖的 OCT 组件和技术融入新的 OCTA 仪器，可应用于研究和提供 商业化和临床使用的途径。该成像系统将利用敏捷设计能力 我们的低成本 OCT 引擎，使我们能够提供第一个商业 OCT 研究系统，以低价出售 价格低于 10,000 美元。对于这个项目，我们将实现更快的扫描，A 扫描速率高达 80 kHz， 实施可提高 OCTA 扫描采集效率并扩展光谱范围的扫描模式 我们的 OCT 系统允许使用光谱信息来测量血氧。 OCTA 最感兴趣的是评估视网膜脉管系统作为荧光素血管造影的替代方案 （FA），因为它避免了对荧光造影剂的需要。低成本 OCTA 可以扩展该技术的应用 该技术不仅对有症状的患者进行视网膜疾病诊断，还包括更广泛的患者筛查。为了 在这个项目中，我们对在眼科以外的领域开发 OCTA 用例特别感兴趣， 包括评估组织灌注和神经缺陷。我们试图证明低风险的可行性 适合商业化的成本OCTA系统。为了实现这一目标，以下具体目标是 建议： 1.开发低成本OCTA引擎和分析软件。 2. 添加光谱信息 OCTA 和 3. 通过体内试点研究测试和验证 OCTA 系统。该项目完成后我们将 证明了低成本 OCTA 用于血管网络结构和功能成像的可行性 并为进一步的商业发展提供了理由。